Epigenetic Silencing of PTEN and Epi-Transcriptional Silencing of MDM2 Underlied Progression to Secondary Acute Myeloid Leukemia in Myelodysplastic Syndrome Treated with Hypomethylating Agents

In myelodysplastic syndrome (MDS), resistance to hypomethylating agents (HMA) portends a poor prognosis, underscoring the importance of understanding the molecular mechanisms leading to HMA-resistance. In this study, P39 and Kasumi-1 cells and their azacitidine-resistant and decitabine-resistant sub...

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Detalles Bibliográficos
Autores principales: Lee, Paul, Yim, Rita, Miu, Kai-Kei, Fung, Sin-Hang, Liao, Jason Jinyue, Wang, Zhangting, Li, Jun, Yung, Yammy, Chu, Hiu-Tung, Yip, Pui-Kwan, Lee, Emily, Tse, Eric, Kwong, Yok-Lam, Gill, Harinder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144309/
https://www.ncbi.nlm.nih.gov/pubmed/35628480
http://dx.doi.org/10.3390/ijms23105670

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