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Multicomponent Synthesis of Unsaturated γ-Lactam Derivatives. Applications as Antiproliferative Agents through the Bioisosterism Approach: Carbonyl vs. Phosphoryl Group

We report efficient synthetic methodologies for the preparation of 3-amino and 3-hydroxy 3-pyrrolin-2-ones (unsaturated γ-lactams) through a multicomponent reaction of amines, aldehydes and acetylene or pyruvate derivatives. The densely substituted γ-lactam substrates show in vitro cytotoxicity, inh...

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Detalles Bibliográficos
Autores principales:	del Corte, Xabier, López-Francés, Adrián, Villate-Beitia, Ilia, Sainz-Ramos, Myriam, Martínez de Marigorta, Edorta, Palacios, Francisco, Alonso, Concepción, de los Santos, Jesús M., Pedraz, José Luis, Vicario, Javier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144317/ https://www.ncbi.nlm.nih.gov/pubmed/35631337 http://dx.doi.org/10.3390/ph15050511

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