High-Dose Acetaminophen Alters the Integrity of the Blood–Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats

The consumption of acetaminophen (APAP) can induce neurological changes in human subjects; however, effects of APAP on blood–brain barrier (BBB) integrity are unknown. BBB changes by APAP can have profound consequences for brain delivery of co-administered drugs. To study APAP effects, female Spragu...

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Detalles Bibliográficos
Autores principales: Yang, Junzhi, Betterton, Robert D., Williams, Erica I., Stanton, Joshua A., Reddell, Elizabeth S., Ogbonnaya, Chidinma E., Dorn, Emma, Davis, Thomas P., Lochhead, Jeffrey J., Ronaldson, Patrick T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144323/
https://www.ncbi.nlm.nih.gov/pubmed/35631535
http://dx.doi.org/10.3390/pharmaceutics14050949

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