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Comparison of Hepatic Tissue Characterization between T1-Mapping and Non-Contrast Computed Tomography

Background: Non-contrast computed tomography (CT) is frequently used to assess non-alcoholic/metabolic fatty liver disease (NAFLD/MAFLD), which is associated with cardiovascular risk. Although liver biopsy is considered the gold standard for diagnosis, standardized scores and non-contrast computed t...

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Autores principales: Bardach, Constanze, Morski, Leonie, Mascherbauer, Katharina, Donà, Carolina, Koschutnik, Matthias, Halavina, Kseniya, Nitsche, Christian, Beitzke, Dietrich, Loewe, Christian, Waldmann, Elisabeth, Trauner, Michael, Mascherbauer, Julia, Hengstenberg, Christian, Kammerlander, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144343/
https://www.ncbi.nlm.nih.gov/pubmed/35628989
http://dx.doi.org/10.3390/jcm11102863
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author Bardach, Constanze
Morski, Leonie
Mascherbauer, Katharina
Donà, Carolina
Koschutnik, Matthias
Halavina, Kseniya
Nitsche, Christian
Beitzke, Dietrich
Loewe, Christian
Waldmann, Elisabeth
Trauner, Michael
Mascherbauer, Julia
Hengstenberg, Christian
Kammerlander, Andreas
author_facet Bardach, Constanze
Morski, Leonie
Mascherbauer, Katharina
Donà, Carolina
Koschutnik, Matthias
Halavina, Kseniya
Nitsche, Christian
Beitzke, Dietrich
Loewe, Christian
Waldmann, Elisabeth
Trauner, Michael
Mascherbauer, Julia
Hengstenberg, Christian
Kammerlander, Andreas
author_sort Bardach, Constanze
collection PubMed
description Background: Non-contrast computed tomography (CT) is frequently used to assess non-alcoholic/metabolic fatty liver disease (NAFLD/MAFLD), which is associated with cardiovascular risk. Although liver biopsy is considered the gold standard for diagnosis, standardized scores and non-contrast computed tomography (CT) are used instead. On standard cardiac T1-maps on cardiovascular imaging (CMR) exams for myocardial tissue characterization hepatic tissue is also visible. We hypothesized that there is a significant correlation between hepatic tissue T1-times on CMR and Hounsfield units (HU) on non-contrast CT. Methods: We retrospectively identified patients undergoing a non-contrast CT including the abdomen, a CMR including T1-mapping, and laboratory assessment within 30 days. Patients with storage diseases were excluded. Results: We identified 271 patients (62 ± 15 y/o, 49% female) undergoing non-contrast CT and CMR T1-mapping within 30 days. Mean hepatic HU values were 54 ± 11 on CT and native T1-times were 598 ± 102 ms on CMR and there was a weak, but significant, correlation between these parameters (r = −0.136, p = 0.025). On age and sex adjusted regression analysis, lower liver HU values indicated a dismal cardiometabolic risk profile, including higher HbA1C (p = 0.005) and higher body mass index (p < 0.001). In contrast, native hepatic T1-times yielded a more pronounced cardiac risk profile, including impaired systolic function (p = 0.045) and higher NT-proBNP values (N-Terminal Brain Natriuretic Peptide) (p = 0.004). Conclusions: Hepatic T1-times are easy to assess on standard T1-maps on CMR but only weakly correlated with hepatic HU values on CT and clinical NAFLD/MAFLD scores. Liver T1-times, however, are linked to impaired systolic function and higher natriuretic peptide levels. The prognostic value and clinical usefulness of hepatic T1-times in CMR cohorts warrants further research.
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spelling pubmed-91443432022-05-29 Comparison of Hepatic Tissue Characterization between T1-Mapping and Non-Contrast Computed Tomography Bardach, Constanze Morski, Leonie Mascherbauer, Katharina Donà, Carolina Koschutnik, Matthias Halavina, Kseniya Nitsche, Christian Beitzke, Dietrich Loewe, Christian Waldmann, Elisabeth Trauner, Michael Mascherbauer, Julia Hengstenberg, Christian Kammerlander, Andreas J Clin Med Article Background: Non-contrast computed tomography (CT) is frequently used to assess non-alcoholic/metabolic fatty liver disease (NAFLD/MAFLD), which is associated with cardiovascular risk. Although liver biopsy is considered the gold standard for diagnosis, standardized scores and non-contrast computed tomography (CT) are used instead. On standard cardiac T1-maps on cardiovascular imaging (CMR) exams for myocardial tissue characterization hepatic tissue is also visible. We hypothesized that there is a significant correlation between hepatic tissue T1-times on CMR and Hounsfield units (HU) on non-contrast CT. Methods: We retrospectively identified patients undergoing a non-contrast CT including the abdomen, a CMR including T1-mapping, and laboratory assessment within 30 days. Patients with storage diseases were excluded. Results: We identified 271 patients (62 ± 15 y/o, 49% female) undergoing non-contrast CT and CMR T1-mapping within 30 days. Mean hepatic HU values were 54 ± 11 on CT and native T1-times were 598 ± 102 ms on CMR and there was a weak, but significant, correlation between these parameters (r = −0.136, p = 0.025). On age and sex adjusted regression analysis, lower liver HU values indicated a dismal cardiometabolic risk profile, including higher HbA1C (p = 0.005) and higher body mass index (p < 0.001). In contrast, native hepatic T1-times yielded a more pronounced cardiac risk profile, including impaired systolic function (p = 0.045) and higher NT-proBNP values (N-Terminal Brain Natriuretic Peptide) (p = 0.004). Conclusions: Hepatic T1-times are easy to assess on standard T1-maps on CMR but only weakly correlated with hepatic HU values on CT and clinical NAFLD/MAFLD scores. Liver T1-times, however, are linked to impaired systolic function and higher natriuretic peptide levels. The prognostic value and clinical usefulness of hepatic T1-times in CMR cohorts warrants further research. MDPI 2022-05-19 /pmc/articles/PMC9144343/ /pubmed/35628989 http://dx.doi.org/10.3390/jcm11102863 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bardach, Constanze
Morski, Leonie
Mascherbauer, Katharina
Donà, Carolina
Koschutnik, Matthias
Halavina, Kseniya
Nitsche, Christian
Beitzke, Dietrich
Loewe, Christian
Waldmann, Elisabeth
Trauner, Michael
Mascherbauer, Julia
Hengstenberg, Christian
Kammerlander, Andreas
Comparison of Hepatic Tissue Characterization between T1-Mapping and Non-Contrast Computed Tomography
title Comparison of Hepatic Tissue Characterization between T1-Mapping and Non-Contrast Computed Tomography
title_full Comparison of Hepatic Tissue Characterization between T1-Mapping and Non-Contrast Computed Tomography
title_fullStr Comparison of Hepatic Tissue Characterization between T1-Mapping and Non-Contrast Computed Tomography
title_full_unstemmed Comparison of Hepatic Tissue Characterization between T1-Mapping and Non-Contrast Computed Tomography
title_short Comparison of Hepatic Tissue Characterization between T1-Mapping and Non-Contrast Computed Tomography
title_sort comparison of hepatic tissue characterization between t1-mapping and non-contrast computed tomography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144343/
https://www.ncbi.nlm.nih.gov/pubmed/35628989
http://dx.doi.org/10.3390/jcm11102863
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