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The Combined Value of Type2 Inflammatory Markers in Chronic Obstructive Pulmonary Disease
The roles of type2 inflammatory markers in chronic airway diseases have been assessed in previous studies. However, the relationship between the combined value of these biomarkers and chronic obstructive pulmonary disease (COPD) has not been fully elucidated. We aimed to investigate the roles of the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144416/ https://www.ncbi.nlm.nih.gov/pubmed/35628917 http://dx.doi.org/10.3390/jcm11102791 |
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author | Liu, Yunhuan Ma, Guanhua Mou, Yan Liu, Xuanqi Qiu, Wenjia Zheng, Yang Zhu, Huili Ge, Haiyan |
author_facet | Liu, Yunhuan Ma, Guanhua Mou, Yan Liu, Xuanqi Qiu, Wenjia Zheng, Yang Zhu, Huili Ge, Haiyan |
author_sort | Liu, Yunhuan |
collection | PubMed |
description | The roles of type2 inflammatory markers in chronic airway diseases have been assessed in previous studies. However, the relationship between the combined value of these biomarkers and chronic obstructive pulmonary disease (COPD) has not been fully elucidated. We aimed to investigate the roles of the combined value of the fraction of exhaled nitric oxide (FeNO) level and blood eosinophil count in COPD and the predictive capability of these biomarkers. In total, 266 patients were included in our analysis. When the two type2 biomarkers were assessed separately, there were limited correlations between either increased FeNO level or blood eosinophil count and decreased incidence of total exacerbation or frequency of mild exacerbation. Combining these two biomarkers strengthened their association with both incidence and frequency of acute exacerbation. In addition, during further assessment, simultaneously increased FeNO level and blood eosinophil count were associated with both mild and moderate acute exacerbation. Among the subjects included in this analysis, although the predictive capability was improved when these two biomarkers were combined, the improvement was not statistically significant, indicating the need to increase the sample size. The combination of FeNO level and blood eosinophil count exhibited strong and independent additive value in the assessment of acute exacerbation in COPD; simultaneously increased FeNO level and blood eosinophil count played a protective role in progression of COPD. |
format | Online Article Text |
id | pubmed-9144416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91444162022-05-29 The Combined Value of Type2 Inflammatory Markers in Chronic Obstructive Pulmonary Disease Liu, Yunhuan Ma, Guanhua Mou, Yan Liu, Xuanqi Qiu, Wenjia Zheng, Yang Zhu, Huili Ge, Haiyan J Clin Med Article The roles of type2 inflammatory markers in chronic airway diseases have been assessed in previous studies. However, the relationship between the combined value of these biomarkers and chronic obstructive pulmonary disease (COPD) has not been fully elucidated. We aimed to investigate the roles of the combined value of the fraction of exhaled nitric oxide (FeNO) level and blood eosinophil count in COPD and the predictive capability of these biomarkers. In total, 266 patients were included in our analysis. When the two type2 biomarkers were assessed separately, there were limited correlations between either increased FeNO level or blood eosinophil count and decreased incidence of total exacerbation or frequency of mild exacerbation. Combining these two biomarkers strengthened their association with both incidence and frequency of acute exacerbation. In addition, during further assessment, simultaneously increased FeNO level and blood eosinophil count were associated with both mild and moderate acute exacerbation. Among the subjects included in this analysis, although the predictive capability was improved when these two biomarkers were combined, the improvement was not statistically significant, indicating the need to increase the sample size. The combination of FeNO level and blood eosinophil count exhibited strong and independent additive value in the assessment of acute exacerbation in COPD; simultaneously increased FeNO level and blood eosinophil count played a protective role in progression of COPD. MDPI 2022-05-16 /pmc/articles/PMC9144416/ /pubmed/35628917 http://dx.doi.org/10.3390/jcm11102791 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Liu, Yunhuan Ma, Guanhua Mou, Yan Liu, Xuanqi Qiu, Wenjia Zheng, Yang Zhu, Huili Ge, Haiyan The Combined Value of Type2 Inflammatory Markers in Chronic Obstructive Pulmonary Disease |
title | The Combined Value of Type2 Inflammatory Markers in Chronic Obstructive Pulmonary Disease |
title_full | The Combined Value of Type2 Inflammatory Markers in Chronic Obstructive Pulmonary Disease |
title_fullStr | The Combined Value of Type2 Inflammatory Markers in Chronic Obstructive Pulmonary Disease |
title_full_unstemmed | The Combined Value of Type2 Inflammatory Markers in Chronic Obstructive Pulmonary Disease |
title_short | The Combined Value of Type2 Inflammatory Markers in Chronic Obstructive Pulmonary Disease |
title_sort | combined value of type2 inflammatory markers in chronic obstructive pulmonary disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144416/ https://www.ncbi.nlm.nih.gov/pubmed/35628917 http://dx.doi.org/10.3390/jcm11102791 |
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