Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism

Cytosolic nucleotidases (cNs) catalyze dephosphorylation of nucleoside 5’-monophosphates and thereby contribute to the regulation of nucleotide levels in cells. cNs have also been shown to dephosphorylate several therapeutically relevant nucleotide analogues. cN-IIIB has shown in vitro a distinctive...

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Detalles Bibliográficos
Autores principales: Kubacka, Dorota, Kozarski, Mateusz, Baranowski, Marek R., Wojcik, Radoslaw, Panecka-Hofman, Joanna, Strzelecka, Dominika, Basquin, Jerome, Jemielity, Jacek, Kowalska, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144445/
https://www.ncbi.nlm.nih.gov/pubmed/35631380
http://dx.doi.org/10.3390/ph15050554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144445/
https://www.ncbi.nlm.nih.gov/pubmed/35631380
http://dx.doi.org/10.3390/ph15050554

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