Cargando…

Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism

Cytosolic nucleotidases (cNs) catalyze dephosphorylation of nucleoside 5’-monophosphates and thereby contribute to the regulation of nucleotide levels in cells. cNs have also been shown to dephosphorylate several therapeutically relevant nucleotide analogues. cN-IIIB has shown in vitro a distinctive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kubacka, Dorota, Kozarski, Mateusz, Baranowski, Marek R., Wojcik, Radoslaw, Panecka-Hofman, Joanna, Strzelecka, Dominika, Basquin, Jerome, Jemielity, Jacek, Kowalska, Joanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144445/ https://www.ncbi.nlm.nih.gov/pubmed/35631380 http://dx.doi.org/10.3390/ph15050554

Ejemplares similares

Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5′ cap Analogs: Synthesis and Evaluation as Modulators of Translation †
por: Wojcik, Radoslaw, et al.
Publicado: (2021)

Crystal Structures of the Novel Cytosolic 5′-Nucleotidase IIIB Explain Its Preference for m(7)GMP
por: Monecke, Thomas, et al.
Publicado: (2014)

Towards superior mRNA caps accessible by click chemistry: synthesis and translational properties of triazole-bearing oligonucleotide cap analogs
por: Kozarski, Mateusz, et al.
Publicado: (2023)

Analysis of mononucleotides by tandem mass spectrometry: investigation of fragmentation pathways for phosphate- and ribose-modified nucleotide analogues
por: Strzelecka, Dominika, et al.
Publicado: (2017)

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells
por: Sikorski, Pawel J, et al.
Publicado: (2020)

Phosphodiester modifications in mRNA poly(A) tail prevent deadenylation without compromising protein expression
por: Strzelecka, Dominika, et al.
Publicado: (2020)

Quick Access to Nucleobase-Modified Phosphoramidites for the Synthesis of Oligoribonucleotides Containing Post-Transcriptional Modifications and Epitranscriptomic Marks
por: Ziemkiewicz, Kamil, et al.
Publicado: (2022)

A novel route for preparing 5′ cap mimics and capped RNAs: phosphate-modified cap analogues obtained via click chemistry
por: Walczak, Sylwia, et al.
Publicado: (2017)

5′-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by (19)F NMR
por: Baranowski, Marek R, et al.
Publicado: (2020)

Evaluation of carboxyfluorescein-labeled 7-methylguanine nucleotides as probes for studying cap-binding proteins by fluorescence anisotropy
por: Wojtczak, Anna, et al.
Publicado: (2021)

Synthesis of Trifluoromethylated Purine Ribonucleotides and Their Evaluation as (19)F NMR Probes
por: Chrominski, Mikolaj, et al.
Publicado: (2020)

Anti–Cytosolic 5′‐Nucleotidase 1A Autoantibodies Are Absent in Juvenile Dermatomyositis
por: Rietveld, Anke, et al.
Publicado: (2021)

Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect
por: Warminski, Marcin, et al.
Publicado: (2021)

Structure and dynamics of pteridine reductase 1: the key phenomena relevant to enzyme function and drug design
por: Panecka-Hofman, Joanna, et al.
Publicado: (2023)

Bacillus subtilis 5′-nucleotidases with various functions and substrate specificities
por: Terakawa, Ayako, et al.
Publicado: (2016)

Cytosolic 5’-Nucleotidase II Interacts with the Leucin Rich Repeat of NLR Family Member Ipaf
por: Cividini, Federico, et al.
Publicado: (2015)

Autoantibodies to Cytosolic 5′-Nucleotidase 1A in Primary Sjögren’s Syndrome and Systemic Lupus Erythematosus
por: Rietveld, Anke, et al.
Publicado: (2018)

Cytosolic 5′-nucleotidase 1A autoantibody profile and clinical characteristics in inclusion body myositis
por: Lilleker, J B, et al.
Publicado: (2017)

Evidence for a Cross-Talk Between Cytosolic 5′-Nucleotidases and AMP-Activated Protein Kinase
por: Camici, Marcella, et al.
Publicado: (2020)

Clinical utility of anti‐cytosolic 5’‐nucleotidase 1A antibody in idiopathic inflammatory myopathies
por: Ikenaga, Chiseko, et al.
Publicado: (2021)

Fluorinated Phosphoadenosine 5′-Phosphosulfate Analogues for Continuous Sulfotransferase Activity Monitoring and Inhibitor Screening by (19)F NMR Spectroscopy
por: Mlynarska-Cieslak, Agnieszka, et al.
Publicado: (2022)

Substrate Specificity of Chimeric Enzymes Formed by Interchange of the Catalytic and Specificity Domains of the 5′-Nucleotidase UshA and the 3′-Nucleotidase CpdB
por: Cabezas, Alicia, et al.
Publicado: (2021)

Chemically Modified Poly(A) Analogs Targeting PABP: Structure Activity Relationship and Translation Inhibitory Properties
por: Perzanowska, Olga, et al.
Publicado: (2022)

Introducing SuFNucs: Sulfamoyl-Fluoride-Functionalized Nucleosides That Undergo Sulfur Fluoride Exchange Reaction
por: Chrominski, Mikołaj, et al.
Publicado: (2022)

Recent advances in structure and function of cytosolic IMP-GMP specific 5′nucleotidase II (cN-II)
por: Ipata, Piero Luigi, et al.
Publicado: (2006)

Structural Insights into the Inhibition of Cytosolic 5′-Nucleotidase II (cN-II) by Ribonucleoside 5′-Monophosphate Analogues
por: Gallier, Franck, et al.
Publicado: (2011)

The cytosolic 5′-nucleotidase cN-II lowers the adaptability to glucose deprivation in human breast cancer cells
por: Bricard, Gabriel, et al.
Publicado: (2017)

Investigating cytosolic 5′-nucleotidase II family genes as candidates for neuropsychiatric disorders in Drosophila (114/150 chr)
por: Singgih, Euginia L., et al.
Publicado: (2021)

Applications of Phosphate Modification and Labeling to Study (m)RNA Caps
por: Warminski, Marcin, et al.
Publicado: (2017)

Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites
por: Patzak, Melanie S., et al.
Publicado: (2019)

Cytosolic 5′-Nucleotidase II Is a Sensor of Energy Charge and Oxidative Stress: A Possible Function as Metabolic Regulator
por: Pesi, Rossana, et al.
Publicado: (2021)

Chemical Modifications of mRNA Ends for Therapeutic Applications
por: Warminski, Marcin, et al.
Publicado: (2023)

Substrate Specificity of SARS-CoV-2 Nsp10-Nsp16 Methyltransferase
por: Benoni, Roberto, et al.
Publicado: (2021)

Morphine treatment alters nucleotidase activities in rat blood serum
por: Rozisky, Joanna Ripoll, et al.
Publicado: (2012)

N1-Propargylguanosine Modified mRNA Cap Analogs: Synthesis, Reactivity, and Applications to the Study of Cap-Binding Proteins
por: Kopcial, Michal, et al.
Publicado: (2019)

Expression of Bovine Cytosolic 5′-Nucleotidase (cN-II) in Yeast: Nucleotide Pools Disturbance and Its Consequences on Growth and Homologous Recombination
por: Allegrini, Simone, et al.
Publicado: (2013)

Cytosolic 5′-Nucleotidase II Silencing in Lung Tumor Cells Regulates Metabolism through Activation of the p53/AMPK Signaling Pathway
por: Pesi, Rossana, et al.
Publicado: (2021)

Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation
por: Tibble, Ryan W., et al.
Publicado: (2021)

Interplay of the Bacterial Ribosomal A-Site, S12 Protein Mutations and Paromomycin Binding: A Molecular Dynamics Study
por: Panecka, Joanna, et al.
Publicado: (2014)

About Pyrimidine 5’-Nucleotidase Deficiency
por: Özsoylu, Şinasi
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ephlifo68aeqb33h7rss2lluj7