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Association of Albumin-Corrected Serum Calcium Levels with Colorectal Cancer Survival Outcomes
In epidemiological studies, higher calcium intake has been associated with decreased colorectal cancer (CRC) incidence. However, whether circulating calcium concentrations are associated with CRC prognosis is largely unknown. In this retrospective cohort analysis, we identified 498 patients diagnose...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144533/ https://www.ncbi.nlm.nih.gov/pubmed/35629054 http://dx.doi.org/10.3390/jcm11102928 |
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author | Silveira, Marina Nogueira Pozzuto, Lara Mendes, Maria Carolina Santos da Cunha, Lorena Pires Costa, Felipe Osório Macedo, Lígia Traldi Brambilla, Sandra Regina Carvalheira, José Barreto Campello |
author_facet | Silveira, Marina Nogueira Pozzuto, Lara Mendes, Maria Carolina Santos da Cunha, Lorena Pires Costa, Felipe Osório Macedo, Lígia Traldi Brambilla, Sandra Regina Carvalheira, José Barreto Campello |
author_sort | Silveira, Marina Nogueira |
collection | PubMed |
description | In epidemiological studies, higher calcium intake has been associated with decreased colorectal cancer (CRC) incidence. However, whether circulating calcium concentrations are associated with CRC prognosis is largely unknown. In this retrospective cohort analysis, we identified 498 patients diagnosed with stage I–IV CRC between the years of 2000 and 2018 in whom calcium and albumin level measurements within 3 months of diagnosis had been taken. We used the Kaplan–Meier method for survival analysis. We used multivariate Cox proportional hazards regression to identify associations between corrected calcium levels and CRC survival outcomes. Corrected calcium levels in the highest tertile were associated with significantly lower progression-free survival rates (hazard ratio (HR) 1.85; 95% confidence interval (CI) 1.28–2.69; p = 0.001) and overall survival (HR 1.86; 95% CI 1.26–2.74, p = 0.002) in patients with stage IV or recurrent CRC, and significantly lower disease-free survival rates (HR 1.44; 95% confidence interval (CI) 1.02–2.03; p = 0.040) and overall survival rates (HR 1.72; 95% CI 1.18–2.50; p = 0.004) in patients with stage I–III disease. In conclusion, higher corrected calcium levels after the diagnosis of CRC were significantly associated with decreased survival rates. Prospective trials are necessary to confirm this association. |
format | Online Article Text |
id | pubmed-9144533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91445332022-05-29 Association of Albumin-Corrected Serum Calcium Levels with Colorectal Cancer Survival Outcomes Silveira, Marina Nogueira Pozzuto, Lara Mendes, Maria Carolina Santos da Cunha, Lorena Pires Costa, Felipe Osório Macedo, Lígia Traldi Brambilla, Sandra Regina Carvalheira, José Barreto Campello J Clin Med Article In epidemiological studies, higher calcium intake has been associated with decreased colorectal cancer (CRC) incidence. However, whether circulating calcium concentrations are associated with CRC prognosis is largely unknown. In this retrospective cohort analysis, we identified 498 patients diagnosed with stage I–IV CRC between the years of 2000 and 2018 in whom calcium and albumin level measurements within 3 months of diagnosis had been taken. We used the Kaplan–Meier method for survival analysis. We used multivariate Cox proportional hazards regression to identify associations between corrected calcium levels and CRC survival outcomes. Corrected calcium levels in the highest tertile were associated with significantly lower progression-free survival rates (hazard ratio (HR) 1.85; 95% confidence interval (CI) 1.28–2.69; p = 0.001) and overall survival (HR 1.86; 95% CI 1.26–2.74, p = 0.002) in patients with stage IV or recurrent CRC, and significantly lower disease-free survival rates (HR 1.44; 95% confidence interval (CI) 1.02–2.03; p = 0.040) and overall survival rates (HR 1.72; 95% CI 1.18–2.50; p = 0.004) in patients with stage I–III disease. In conclusion, higher corrected calcium levels after the diagnosis of CRC were significantly associated with decreased survival rates. Prospective trials are necessary to confirm this association. MDPI 2022-05-22 /pmc/articles/PMC9144533/ /pubmed/35629054 http://dx.doi.org/10.3390/jcm11102928 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Silveira, Marina Nogueira Pozzuto, Lara Mendes, Maria Carolina Santos da Cunha, Lorena Pires Costa, Felipe Osório Macedo, Lígia Traldi Brambilla, Sandra Regina Carvalheira, José Barreto Campello Association of Albumin-Corrected Serum Calcium Levels with Colorectal Cancer Survival Outcomes |
title | Association of Albumin-Corrected Serum Calcium Levels with Colorectal Cancer Survival Outcomes |
title_full | Association of Albumin-Corrected Serum Calcium Levels with Colorectal Cancer Survival Outcomes |
title_fullStr | Association of Albumin-Corrected Serum Calcium Levels with Colorectal Cancer Survival Outcomes |
title_full_unstemmed | Association of Albumin-Corrected Serum Calcium Levels with Colorectal Cancer Survival Outcomes |
title_short | Association of Albumin-Corrected Serum Calcium Levels with Colorectal Cancer Survival Outcomes |
title_sort | association of albumin-corrected serum calcium levels with colorectal cancer survival outcomes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144533/ https://www.ncbi.nlm.nih.gov/pubmed/35629054 http://dx.doi.org/10.3390/jcm11102928 |
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