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Association of Albumin-Corrected Serum Calcium Levels with Colorectal Cancer Survival Outcomes

In epidemiological studies, higher calcium intake has been associated with decreased colorectal cancer (CRC) incidence. However, whether circulating calcium concentrations are associated with CRC prognosis is largely unknown. In this retrospective cohort analysis, we identified 498 patients diagnose...

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Autores principales: Silveira, Marina Nogueira, Pozzuto, Lara, Mendes, Maria Carolina Santos, da Cunha, Lorena Pires, Costa, Felipe Osório, Macedo, Lígia Traldi, Brambilla, Sandra Regina, Carvalheira, José Barreto Campello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144533/
https://www.ncbi.nlm.nih.gov/pubmed/35629054
http://dx.doi.org/10.3390/jcm11102928
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author Silveira, Marina Nogueira
Pozzuto, Lara
Mendes, Maria Carolina Santos
da Cunha, Lorena Pires
Costa, Felipe Osório
Macedo, Lígia Traldi
Brambilla, Sandra Regina
Carvalheira, José Barreto Campello
author_facet Silveira, Marina Nogueira
Pozzuto, Lara
Mendes, Maria Carolina Santos
da Cunha, Lorena Pires
Costa, Felipe Osório
Macedo, Lígia Traldi
Brambilla, Sandra Regina
Carvalheira, José Barreto Campello
author_sort Silveira, Marina Nogueira
collection PubMed
description In epidemiological studies, higher calcium intake has been associated with decreased colorectal cancer (CRC) incidence. However, whether circulating calcium concentrations are associated with CRC prognosis is largely unknown. In this retrospective cohort analysis, we identified 498 patients diagnosed with stage I–IV CRC between the years of 2000 and 2018 in whom calcium and albumin level measurements within 3 months of diagnosis had been taken. We used the Kaplan–Meier method for survival analysis. We used multivariate Cox proportional hazards regression to identify associations between corrected calcium levels and CRC survival outcomes. Corrected calcium levels in the highest tertile were associated with significantly lower progression-free survival rates (hazard ratio (HR) 1.85; 95% confidence interval (CI) 1.28–2.69; p = 0.001) and overall survival (HR 1.86; 95% CI 1.26–2.74, p = 0.002) in patients with stage IV or recurrent CRC, and significantly lower disease-free survival rates (HR 1.44; 95% confidence interval (CI) 1.02–2.03; p = 0.040) and overall survival rates (HR 1.72; 95% CI 1.18–2.50; p = 0.004) in patients with stage I–III disease. In conclusion, higher corrected calcium levels after the diagnosis of CRC were significantly associated with decreased survival rates. Prospective trials are necessary to confirm this association.
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spelling pubmed-91445332022-05-29 Association of Albumin-Corrected Serum Calcium Levels with Colorectal Cancer Survival Outcomes Silveira, Marina Nogueira Pozzuto, Lara Mendes, Maria Carolina Santos da Cunha, Lorena Pires Costa, Felipe Osório Macedo, Lígia Traldi Brambilla, Sandra Regina Carvalheira, José Barreto Campello J Clin Med Article In epidemiological studies, higher calcium intake has been associated with decreased colorectal cancer (CRC) incidence. However, whether circulating calcium concentrations are associated with CRC prognosis is largely unknown. In this retrospective cohort analysis, we identified 498 patients diagnosed with stage I–IV CRC between the years of 2000 and 2018 in whom calcium and albumin level measurements within 3 months of diagnosis had been taken. We used the Kaplan–Meier method for survival analysis. We used multivariate Cox proportional hazards regression to identify associations between corrected calcium levels and CRC survival outcomes. Corrected calcium levels in the highest tertile were associated with significantly lower progression-free survival rates (hazard ratio (HR) 1.85; 95% confidence interval (CI) 1.28–2.69; p = 0.001) and overall survival (HR 1.86; 95% CI 1.26–2.74, p = 0.002) in patients with stage IV or recurrent CRC, and significantly lower disease-free survival rates (HR 1.44; 95% confidence interval (CI) 1.02–2.03; p = 0.040) and overall survival rates (HR 1.72; 95% CI 1.18–2.50; p = 0.004) in patients with stage I–III disease. In conclusion, higher corrected calcium levels after the diagnosis of CRC were significantly associated with decreased survival rates. Prospective trials are necessary to confirm this association. MDPI 2022-05-22 /pmc/articles/PMC9144533/ /pubmed/35629054 http://dx.doi.org/10.3390/jcm11102928 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Silveira, Marina Nogueira
Pozzuto, Lara
Mendes, Maria Carolina Santos
da Cunha, Lorena Pires
Costa, Felipe Osório
Macedo, Lígia Traldi
Brambilla, Sandra Regina
Carvalheira, José Barreto Campello
Association of Albumin-Corrected Serum Calcium Levels with Colorectal Cancer Survival Outcomes
title Association of Albumin-Corrected Serum Calcium Levels with Colorectal Cancer Survival Outcomes
title_full Association of Albumin-Corrected Serum Calcium Levels with Colorectal Cancer Survival Outcomes
title_fullStr Association of Albumin-Corrected Serum Calcium Levels with Colorectal Cancer Survival Outcomes
title_full_unstemmed Association of Albumin-Corrected Serum Calcium Levels with Colorectal Cancer Survival Outcomes
title_short Association of Albumin-Corrected Serum Calcium Levels with Colorectal Cancer Survival Outcomes
title_sort association of albumin-corrected serum calcium levels with colorectal cancer survival outcomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144533/
https://www.ncbi.nlm.nih.gov/pubmed/35629054
http://dx.doi.org/10.3390/jcm11102928
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