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Through the Looking Glass: Genome, Phenome, and Interactome of Salmonella enterica

This review revisits previous concepts on biological phenomenon contributing to the success of the Salmonella enterica subspecies I as a pathogen and expands upon them to include progress in epidemiology based on whole genome sequencing (WGS). Discussion goes beyond epidemiological uses of WGS to co...

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Detalles Bibliográficos
Autor principal: Guard, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144603/
https://www.ncbi.nlm.nih.gov/pubmed/35631102
http://dx.doi.org/10.3390/pathogens11050581
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author Guard, Jean
author_facet Guard, Jean
author_sort Guard, Jean
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description This review revisits previous concepts on biological phenomenon contributing to the success of the Salmonella enterica subspecies I as a pathogen and expands upon them to include progress in epidemiology based on whole genome sequencing (WGS). Discussion goes beyond epidemiological uses of WGS to consider how phenotype, which is the biological character of an organism, can be correlated with its genotype to develop a knowledge of the interactome. Deciphering genome interactions with proteins, the impact of metabolic flux, epigenetic modifications, and other complex biochemical processes will lead to new therapeutics, control measures, environmental remediations, and improved design of vaccines.
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spelling pubmed-91446032022-05-29 Through the Looking Glass: Genome, Phenome, and Interactome of Salmonella enterica Guard, Jean Pathogens Review This review revisits previous concepts on biological phenomenon contributing to the success of the Salmonella enterica subspecies I as a pathogen and expands upon them to include progress in epidemiology based on whole genome sequencing (WGS). Discussion goes beyond epidemiological uses of WGS to consider how phenotype, which is the biological character of an organism, can be correlated with its genotype to develop a knowledge of the interactome. Deciphering genome interactions with proteins, the impact of metabolic flux, epigenetic modifications, and other complex biochemical processes will lead to new therapeutics, control measures, environmental remediations, and improved design of vaccines. MDPI 2022-05-14 /pmc/articles/PMC9144603/ /pubmed/35631102 http://dx.doi.org/10.3390/pathogens11050581 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Guard, Jean
Through the Looking Glass: Genome, Phenome, and Interactome of Salmonella enterica
title Through the Looking Glass: Genome, Phenome, and Interactome of Salmonella enterica
title_full Through the Looking Glass: Genome, Phenome, and Interactome of Salmonella enterica
title_fullStr Through the Looking Glass: Genome, Phenome, and Interactome of Salmonella enterica
title_full_unstemmed Through the Looking Glass: Genome, Phenome, and Interactome of Salmonella enterica
title_short Through the Looking Glass: Genome, Phenome, and Interactome of Salmonella enterica
title_sort through the looking glass: genome, phenome, and interactome of salmonella enterica
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144603/
https://www.ncbi.nlm.nih.gov/pubmed/35631102
http://dx.doi.org/10.3390/pathogens11050581
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