Cargando…
Through the Looking Glass: Genome, Phenome, and Interactome of Salmonella enterica
This review revisits previous concepts on biological phenomenon contributing to the success of the Salmonella enterica subspecies I as a pathogen and expands upon them to include progress in epidemiology based on whole genome sequencing (WGS). Discussion goes beyond epidemiological uses of WGS to co...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144603/ https://www.ncbi.nlm.nih.gov/pubmed/35631102 http://dx.doi.org/10.3390/pathogens11050581 |
_version_ | 1784716088476434432 |
---|---|
author | Guard, Jean |
author_facet | Guard, Jean |
author_sort | Guard, Jean |
collection | PubMed |
description | This review revisits previous concepts on biological phenomenon contributing to the success of the Salmonella enterica subspecies I as a pathogen and expands upon them to include progress in epidemiology based on whole genome sequencing (WGS). Discussion goes beyond epidemiological uses of WGS to consider how phenotype, which is the biological character of an organism, can be correlated with its genotype to develop a knowledge of the interactome. Deciphering genome interactions with proteins, the impact of metabolic flux, epigenetic modifications, and other complex biochemical processes will lead to new therapeutics, control measures, environmental remediations, and improved design of vaccines. |
format | Online Article Text |
id | pubmed-9144603 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91446032022-05-29 Through the Looking Glass: Genome, Phenome, and Interactome of Salmonella enterica Guard, Jean Pathogens Review This review revisits previous concepts on biological phenomenon contributing to the success of the Salmonella enterica subspecies I as a pathogen and expands upon them to include progress in epidemiology based on whole genome sequencing (WGS). Discussion goes beyond epidemiological uses of WGS to consider how phenotype, which is the biological character of an organism, can be correlated with its genotype to develop a knowledge of the interactome. Deciphering genome interactions with proteins, the impact of metabolic flux, epigenetic modifications, and other complex biochemical processes will lead to new therapeutics, control measures, environmental remediations, and improved design of vaccines. MDPI 2022-05-14 /pmc/articles/PMC9144603/ /pubmed/35631102 http://dx.doi.org/10.3390/pathogens11050581 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Guard, Jean Through the Looking Glass: Genome, Phenome, and Interactome of Salmonella enterica |
title | Through the Looking Glass: Genome, Phenome, and Interactome of Salmonella enterica |
title_full | Through the Looking Glass: Genome, Phenome, and Interactome of Salmonella enterica |
title_fullStr | Through the Looking Glass: Genome, Phenome, and Interactome of Salmonella enterica |
title_full_unstemmed | Through the Looking Glass: Genome, Phenome, and Interactome of Salmonella enterica |
title_short | Through the Looking Glass: Genome, Phenome, and Interactome of Salmonella enterica |
title_sort | through the looking glass: genome, phenome, and interactome of salmonella enterica |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144603/ https://www.ncbi.nlm.nih.gov/pubmed/35631102 http://dx.doi.org/10.3390/pathogens11050581 |
work_keys_str_mv | AT guardjean throughthelookingglassgenomephenomeandinteractomeofsalmonellaenterica |