Activation of Host-NLRP3 Inflammasome in Myeloid Cells Dictates Response to Anti-PD-1 Therapy in Metastatic Breast Cancers

Tumor-associated inflammation leads to dysregulated cytokine production that promotes tumor immune evasion and anti-tumor immunity dysfunction. In advanced stage breast cancer, the proinflammatory cytokine IL-1β is overexpressed due to large proportions of activated myeloid cells in the tumor microe...

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Detalles Bibliográficos
Autores principales: Tengesdal, Isak W., Li, Suzhao, Powers, Nicholas E., May, Makenna, Neff, Charles P., Joosten, Leo A. B., Marchetti, Carlo, Dinarello, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144656/
https://www.ncbi.nlm.nih.gov/pubmed/35631400
http://dx.doi.org/10.3390/ph15050574

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