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Hypertension in Patients with Insulin Resistance: Etiopathogenesis and Management in Children

Insulin resistance (IR) is a key component in the etiopathogenesis of hypertension (HS) in patients with diabetes mellitus (DM). Several pathways have been found to be involved in this mechanism in recent literature. For the above-mentioned reasons, treatment of HS should be specifically addressed i...

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Autores principales: Tagi, Veronica Maria, Mainieri, Francesca, Chiarelli, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144705/
https://www.ncbi.nlm.nih.gov/pubmed/35628624
http://dx.doi.org/10.3390/ijms23105814
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author Tagi, Veronica Maria
Mainieri, Francesca
Chiarelli, Francesco
author_facet Tagi, Veronica Maria
Mainieri, Francesca
Chiarelli, Francesco
author_sort Tagi, Veronica Maria
collection PubMed
description Insulin resistance (IR) is a key component in the etiopathogenesis of hypertension (HS) in patients with diabetes mellitus (DM). Several pathways have been found to be involved in this mechanism in recent literature. For the above-mentioned reasons, treatment of HS should be specifically addressed in patients affected by DM. Two relevant recently published guidelines have stressed this concept, giving specific advice in the treatment of HS in children belonging to this group: the European Society of HS guidelines for the management of high blood pressure in children and adolescents and the American Academy of Pediatrics Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents. Our aim is to summarize the main pathophysiological mechanisms through which IR causes HS and to highlight the specific principles of treatment of HS for children with DM.
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spelling pubmed-91447052022-05-29 Hypertension in Patients with Insulin Resistance: Etiopathogenesis and Management in Children Tagi, Veronica Maria Mainieri, Francesca Chiarelli, Francesco Int J Mol Sci Review Insulin resistance (IR) is a key component in the etiopathogenesis of hypertension (HS) in patients with diabetes mellitus (DM). Several pathways have been found to be involved in this mechanism in recent literature. For the above-mentioned reasons, treatment of HS should be specifically addressed in patients affected by DM. Two relevant recently published guidelines have stressed this concept, giving specific advice in the treatment of HS in children belonging to this group: the European Society of HS guidelines for the management of high blood pressure in children and adolescents and the American Academy of Pediatrics Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents. Our aim is to summarize the main pathophysiological mechanisms through which IR causes HS and to highlight the specific principles of treatment of HS for children with DM. MDPI 2022-05-22 /pmc/articles/PMC9144705/ /pubmed/35628624 http://dx.doi.org/10.3390/ijms23105814 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tagi, Veronica Maria
Mainieri, Francesca
Chiarelli, Francesco
Hypertension in Patients with Insulin Resistance: Etiopathogenesis and Management in Children
title Hypertension in Patients with Insulin Resistance: Etiopathogenesis and Management in Children
title_full Hypertension in Patients with Insulin Resistance: Etiopathogenesis and Management in Children
title_fullStr Hypertension in Patients with Insulin Resistance: Etiopathogenesis and Management in Children
title_full_unstemmed Hypertension in Patients with Insulin Resistance: Etiopathogenesis and Management in Children
title_short Hypertension in Patients with Insulin Resistance: Etiopathogenesis and Management in Children
title_sort hypertension in patients with insulin resistance: etiopathogenesis and management in children
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144705/
https://www.ncbi.nlm.nih.gov/pubmed/35628624
http://dx.doi.org/10.3390/ijms23105814
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