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Epidemiology and Characteristics of Elizabethkingia spp. Infections in Southeast Asia
Elizabethkingia spp. is a ubiquitous pathogenic bacterium that has been identified as the causal agent for a variety of conditions such as meningitis, pneumonia, necrotizing fasciitis, endophthalmitis, and sepsis and is emerging as a global threat including in Southeast Asia. Elizabethkingia infecti...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144721/ https://www.ncbi.nlm.nih.gov/pubmed/35630327 http://dx.doi.org/10.3390/microorganisms10050882 |
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author | Zajmi, Asdren Teo, Jeanette Yeo, Chew Chieng |
author_facet | Zajmi, Asdren Teo, Jeanette Yeo, Chew Chieng |
author_sort | Zajmi, Asdren |
collection | PubMed |
description | Elizabethkingia spp. is a ubiquitous pathogenic bacterium that has been identified as the causal agent for a variety of conditions such as meningitis, pneumonia, necrotizing fasciitis, endophthalmitis, and sepsis and is emerging as a global threat including in Southeast Asia. Elizabethkingia infections tend to be associated with high mortality rates (18.2–41%) and are mostly observed in neonates and immunocompromised patients. Difficulties in precisely identifying Elizabethkingia at the species level by traditional methods have hampered our understanding of this genus in human infections. In Southeast Asian countries, hospital outbreaks have usually been ascribed to E. meningoseptica, whereas in Singapore, E. anophelis was reported as the main Elizabethkingia spp. associated with hospital settings. Misidentification of Elizabethkingia spp. could, however, underestimate the number of cases attributed to the bacterium, as precise identification requires tools such as MALDI-TOF MS, and particularly whole-genome sequencing, which are not available in most hospital laboratories. Elizabethkingia spp. has an unusual antibiotic resistance pattern for a Gram-negative bacterium with a limited number of horizontal gene transfers, which suggests an intrinsic origin for its multidrug resistance. Efforts to prevent and further understand Elizabethkingia spp. infections and limit its spread must rise to this new challenge. |
format | Online Article Text |
id | pubmed-9144721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91447212022-05-29 Epidemiology and Characteristics of Elizabethkingia spp. Infections in Southeast Asia Zajmi, Asdren Teo, Jeanette Yeo, Chew Chieng Microorganisms Review Elizabethkingia spp. is a ubiquitous pathogenic bacterium that has been identified as the causal agent for a variety of conditions such as meningitis, pneumonia, necrotizing fasciitis, endophthalmitis, and sepsis and is emerging as a global threat including in Southeast Asia. Elizabethkingia infections tend to be associated with high mortality rates (18.2–41%) and are mostly observed in neonates and immunocompromised patients. Difficulties in precisely identifying Elizabethkingia at the species level by traditional methods have hampered our understanding of this genus in human infections. In Southeast Asian countries, hospital outbreaks have usually been ascribed to E. meningoseptica, whereas in Singapore, E. anophelis was reported as the main Elizabethkingia spp. associated with hospital settings. Misidentification of Elizabethkingia spp. could, however, underestimate the number of cases attributed to the bacterium, as precise identification requires tools such as MALDI-TOF MS, and particularly whole-genome sequencing, which are not available in most hospital laboratories. Elizabethkingia spp. has an unusual antibiotic resistance pattern for a Gram-negative bacterium with a limited number of horizontal gene transfers, which suggests an intrinsic origin for its multidrug resistance. Efforts to prevent and further understand Elizabethkingia spp. infections and limit its spread must rise to this new challenge. MDPI 2022-04-22 /pmc/articles/PMC9144721/ /pubmed/35630327 http://dx.doi.org/10.3390/microorganisms10050882 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zajmi, Asdren Teo, Jeanette Yeo, Chew Chieng Epidemiology and Characteristics of Elizabethkingia spp. Infections in Southeast Asia |
title | Epidemiology and Characteristics of Elizabethkingia spp. Infections in Southeast Asia |
title_full | Epidemiology and Characteristics of Elizabethkingia spp. Infections in Southeast Asia |
title_fullStr | Epidemiology and Characteristics of Elizabethkingia spp. Infections in Southeast Asia |
title_full_unstemmed | Epidemiology and Characteristics of Elizabethkingia spp. Infections in Southeast Asia |
title_short | Epidemiology and Characteristics of Elizabethkingia spp. Infections in Southeast Asia |
title_sort | epidemiology and characteristics of elizabethkingia spp. infections in southeast asia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144721/ https://www.ncbi.nlm.nih.gov/pubmed/35630327 http://dx.doi.org/10.3390/microorganisms10050882 |
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