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Epidemiology and Characteristics of Elizabethkingia spp. Infections in Southeast Asia

Elizabethkingia spp. is a ubiquitous pathogenic bacterium that has been identified as the causal agent for a variety of conditions such as meningitis, pneumonia, necrotizing fasciitis, endophthalmitis, and sepsis and is emerging as a global threat including in Southeast Asia. Elizabethkingia infecti...

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Autores principales: Zajmi, Asdren, Teo, Jeanette, Yeo, Chew Chieng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144721/
https://www.ncbi.nlm.nih.gov/pubmed/35630327
http://dx.doi.org/10.3390/microorganisms10050882
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author Zajmi, Asdren
Teo, Jeanette
Yeo, Chew Chieng
author_facet Zajmi, Asdren
Teo, Jeanette
Yeo, Chew Chieng
author_sort Zajmi, Asdren
collection PubMed
description Elizabethkingia spp. is a ubiquitous pathogenic bacterium that has been identified as the causal agent for a variety of conditions such as meningitis, pneumonia, necrotizing fasciitis, endophthalmitis, and sepsis and is emerging as a global threat including in Southeast Asia. Elizabethkingia infections tend to be associated with high mortality rates (18.2–41%) and are mostly observed in neonates and immunocompromised patients. Difficulties in precisely identifying Elizabethkingia at the species level by traditional methods have hampered our understanding of this genus in human infections. In Southeast Asian countries, hospital outbreaks have usually been ascribed to E. meningoseptica, whereas in Singapore, E. anophelis was reported as the main Elizabethkingia spp. associated with hospital settings. Misidentification of Elizabethkingia spp. could, however, underestimate the number of cases attributed to the bacterium, as precise identification requires tools such as MALDI-TOF MS, and particularly whole-genome sequencing, which are not available in most hospital laboratories. Elizabethkingia spp. has an unusual antibiotic resistance pattern for a Gram-negative bacterium with a limited number of horizontal gene transfers, which suggests an intrinsic origin for its multidrug resistance. Efforts to prevent and further understand Elizabethkingia spp. infections and limit its spread must rise to this new challenge.
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spelling pubmed-91447212022-05-29 Epidemiology and Characteristics of Elizabethkingia spp. Infections in Southeast Asia Zajmi, Asdren Teo, Jeanette Yeo, Chew Chieng Microorganisms Review Elizabethkingia spp. is a ubiquitous pathogenic bacterium that has been identified as the causal agent for a variety of conditions such as meningitis, pneumonia, necrotizing fasciitis, endophthalmitis, and sepsis and is emerging as a global threat including in Southeast Asia. Elizabethkingia infections tend to be associated with high mortality rates (18.2–41%) and are mostly observed in neonates and immunocompromised patients. Difficulties in precisely identifying Elizabethkingia at the species level by traditional methods have hampered our understanding of this genus in human infections. In Southeast Asian countries, hospital outbreaks have usually been ascribed to E. meningoseptica, whereas in Singapore, E. anophelis was reported as the main Elizabethkingia spp. associated with hospital settings. Misidentification of Elizabethkingia spp. could, however, underestimate the number of cases attributed to the bacterium, as precise identification requires tools such as MALDI-TOF MS, and particularly whole-genome sequencing, which are not available in most hospital laboratories. Elizabethkingia spp. has an unusual antibiotic resistance pattern for a Gram-negative bacterium with a limited number of horizontal gene transfers, which suggests an intrinsic origin for its multidrug resistance. Efforts to prevent and further understand Elizabethkingia spp. infections and limit its spread must rise to this new challenge. MDPI 2022-04-22 /pmc/articles/PMC9144721/ /pubmed/35630327 http://dx.doi.org/10.3390/microorganisms10050882 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zajmi, Asdren
Teo, Jeanette
Yeo, Chew Chieng
Epidemiology and Characteristics of Elizabethkingia spp. Infections in Southeast Asia
title Epidemiology and Characteristics of Elizabethkingia spp. Infections in Southeast Asia
title_full Epidemiology and Characteristics of Elizabethkingia spp. Infections in Southeast Asia
title_fullStr Epidemiology and Characteristics of Elizabethkingia spp. Infections in Southeast Asia
title_full_unstemmed Epidemiology and Characteristics of Elizabethkingia spp. Infections in Southeast Asia
title_short Epidemiology and Characteristics of Elizabethkingia spp. Infections in Southeast Asia
title_sort epidemiology and characteristics of elizabethkingia spp. infections in southeast asia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144721/
https://www.ncbi.nlm.nih.gov/pubmed/35630327
http://dx.doi.org/10.3390/microorganisms10050882
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