Cargando…

Weight Change across Adulthood in Relation to Non-Alcoholic Fatty Liver Disease among Non-Obese Individuals

Background: To investigate the associations of weight change patterns across adulthood with the risk of non-alcoholic fatty liver disease (NAFLD). Methods: Using data from the National Health and Nutrition Examination Survey (NHANES) 2017–2018 cycle, we performed a retrospective cohort study with 22...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Yuqing, Xu, Xin, Tian, Ting, Yu, Chengxiao, Ge, Xinyuan, Gao, Jiaxin, Lu, Jing, Ge, Zijun, Jiang, Tao, Jiang, Yue, Ma, Hongxia, Song, Ci, Hu, Zhibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144793/
https://www.ncbi.nlm.nih.gov/pubmed/35631281
http://dx.doi.org/10.3390/nu14102140
_version_ 1784716134802522112
author Ding, Yuqing
Xu, Xin
Tian, Ting
Yu, Chengxiao
Ge, Xinyuan
Gao, Jiaxin
Lu, Jing
Ge, Zijun
Jiang, Tao
Jiang, Yue
Ma, Hongxia
Song, Ci
Hu, Zhibin
author_facet Ding, Yuqing
Xu, Xin
Tian, Ting
Yu, Chengxiao
Ge, Xinyuan
Gao, Jiaxin
Lu, Jing
Ge, Zijun
Jiang, Tao
Jiang, Yue
Ma, Hongxia
Song, Ci
Hu, Zhibin
author_sort Ding, Yuqing
collection PubMed
description Background: To investigate the associations of weight change patterns across adulthood with the risk of non-alcoholic fatty liver disease (NAFLD). Methods: Using data from the National Health and Nutrition Examination Survey (NHANES) 2017–2018 cycle, we performed a retrospective cohort study with 2212 non-obese participants aged 36 years old over. Weight change patterns were categorized as “stable non-obese”, “early adulthood weight gain”, “middle and late adulthood weight gain” and “revert to non-obese” according to the body mass index (BMI) at age 25, 10 years prior and at baseline. Vibration-controlled transient elastography (VCTE) was performed to diagnose NAFLD. Modified Poisson regression was used to quantify the associations of weight change patterns with NAFLD. Results: Compared with participants in the “stable non-obese” group, those who gained weight at early or middle and late adulthood had an increased risk of NAFLD, with an adjusted rate ratio (RR) of 2.19 (95% CI 1.64–2.91) and 1.92 (95% CI 1.40–2.62), respectively. The risk of NAFLD in “revert to the non-obese” group showed no significant difference with the stable non-obese group. If the association of weight change and NAFLD was causal, we estimated that 73.09% (95% CI 55.62–82.93%) of incident NAFLD would be prevented if the total population had a normal BMI across adulthood. Conclusions: Weight gain to obese at early or middle and late adulthood was associated with an evaluated risk of NAFLD. A large proportion would have been prevented with effective weight intervention.
format Online
Article
Text
id pubmed-9144793
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91447932022-05-29 Weight Change across Adulthood in Relation to Non-Alcoholic Fatty Liver Disease among Non-Obese Individuals Ding, Yuqing Xu, Xin Tian, Ting Yu, Chengxiao Ge, Xinyuan Gao, Jiaxin Lu, Jing Ge, Zijun Jiang, Tao Jiang, Yue Ma, Hongxia Song, Ci Hu, Zhibin Nutrients Article Background: To investigate the associations of weight change patterns across adulthood with the risk of non-alcoholic fatty liver disease (NAFLD). Methods: Using data from the National Health and Nutrition Examination Survey (NHANES) 2017–2018 cycle, we performed a retrospective cohort study with 2212 non-obese participants aged 36 years old over. Weight change patterns were categorized as “stable non-obese”, “early adulthood weight gain”, “middle and late adulthood weight gain” and “revert to non-obese” according to the body mass index (BMI) at age 25, 10 years prior and at baseline. Vibration-controlled transient elastography (VCTE) was performed to diagnose NAFLD. Modified Poisson regression was used to quantify the associations of weight change patterns with NAFLD. Results: Compared with participants in the “stable non-obese” group, those who gained weight at early or middle and late adulthood had an increased risk of NAFLD, with an adjusted rate ratio (RR) of 2.19 (95% CI 1.64–2.91) and 1.92 (95% CI 1.40–2.62), respectively. The risk of NAFLD in “revert to the non-obese” group showed no significant difference with the stable non-obese group. If the association of weight change and NAFLD was causal, we estimated that 73.09% (95% CI 55.62–82.93%) of incident NAFLD would be prevented if the total population had a normal BMI across adulthood. Conclusions: Weight gain to obese at early or middle and late adulthood was associated with an evaluated risk of NAFLD. A large proportion would have been prevented with effective weight intervention. MDPI 2022-05-20 /pmc/articles/PMC9144793/ /pubmed/35631281 http://dx.doi.org/10.3390/nu14102140 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ding, Yuqing
Xu, Xin
Tian, Ting
Yu, Chengxiao
Ge, Xinyuan
Gao, Jiaxin
Lu, Jing
Ge, Zijun
Jiang, Tao
Jiang, Yue
Ma, Hongxia
Song, Ci
Hu, Zhibin
Weight Change across Adulthood in Relation to Non-Alcoholic Fatty Liver Disease among Non-Obese Individuals
title Weight Change across Adulthood in Relation to Non-Alcoholic Fatty Liver Disease among Non-Obese Individuals
title_full Weight Change across Adulthood in Relation to Non-Alcoholic Fatty Liver Disease among Non-Obese Individuals
title_fullStr Weight Change across Adulthood in Relation to Non-Alcoholic Fatty Liver Disease among Non-Obese Individuals
title_full_unstemmed Weight Change across Adulthood in Relation to Non-Alcoholic Fatty Liver Disease among Non-Obese Individuals
title_short Weight Change across Adulthood in Relation to Non-Alcoholic Fatty Liver Disease among Non-Obese Individuals
title_sort weight change across adulthood in relation to non-alcoholic fatty liver disease among non-obese individuals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144793/
https://www.ncbi.nlm.nih.gov/pubmed/35631281
http://dx.doi.org/10.3390/nu14102140
work_keys_str_mv AT dingyuqing weightchangeacrossadulthoodinrelationtononalcoholicfattyliverdiseaseamongnonobeseindividuals
AT xuxin weightchangeacrossadulthoodinrelationtononalcoholicfattyliverdiseaseamongnonobeseindividuals
AT tianting weightchangeacrossadulthoodinrelationtononalcoholicfattyliverdiseaseamongnonobeseindividuals
AT yuchengxiao weightchangeacrossadulthoodinrelationtononalcoholicfattyliverdiseaseamongnonobeseindividuals
AT gexinyuan weightchangeacrossadulthoodinrelationtononalcoholicfattyliverdiseaseamongnonobeseindividuals
AT gaojiaxin weightchangeacrossadulthoodinrelationtononalcoholicfattyliverdiseaseamongnonobeseindividuals
AT lujing weightchangeacrossadulthoodinrelationtononalcoholicfattyliverdiseaseamongnonobeseindividuals
AT gezijun weightchangeacrossadulthoodinrelationtononalcoholicfattyliverdiseaseamongnonobeseindividuals
AT jiangtao weightchangeacrossadulthoodinrelationtononalcoholicfattyliverdiseaseamongnonobeseindividuals
AT jiangyue weightchangeacrossadulthoodinrelationtononalcoholicfattyliverdiseaseamongnonobeseindividuals
AT mahongxia weightchangeacrossadulthoodinrelationtononalcoholicfattyliverdiseaseamongnonobeseindividuals
AT songci weightchangeacrossadulthoodinrelationtononalcoholicfattyliverdiseaseamongnonobeseindividuals
AT huzhibin weightchangeacrossadulthoodinrelationtononalcoholicfattyliverdiseaseamongnonobeseindividuals