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Different Methods and Formulations of Drugs and Vaccines for Nasal Administration
Nasal drug delivery is advantageous when compared with other routes of drug delivery as it avoids the hepatic first-pass effect, blood–brain barrier penetration, and compliance issues with parenteral administration. However, nasal administration also has some limitations, such as its low bioavailabi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144811/ https://www.ncbi.nlm.nih.gov/pubmed/35631663 http://dx.doi.org/10.3390/pharmaceutics14051073 |
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author | Tai, Junhu Han, Munsoo Lee, Dabin Park, Il-Ho Lee, Sang Hag Kim, Tae Hoon |
author_facet | Tai, Junhu Han, Munsoo Lee, Dabin Park, Il-Ho Lee, Sang Hag Kim, Tae Hoon |
author_sort | Tai, Junhu |
collection | PubMed |
description | Nasal drug delivery is advantageous when compared with other routes of drug delivery as it avoids the hepatic first-pass effect, blood–brain barrier penetration, and compliance issues with parenteral administration. However, nasal administration also has some limitations, such as its low bioavailability due to metabolism on the mucosal surface, and irreversible damage to the nasal mucosa due to the ingredients added into the formula. Moreover, the method of nasal administration is not applicable to all drugs. The current review presents the nasal anatomy and mucosal environment for the nasal delivery of vaccines and drugs, as well as presents various methods for enhancing nasal absorption, and different drug carriers and delivery devices to improve nasal drug delivery. It also presents future prospects on the nasal drug delivery of vaccines and drugs. |
format | Online Article Text |
id | pubmed-9144811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91448112022-05-29 Different Methods and Formulations of Drugs and Vaccines for Nasal Administration Tai, Junhu Han, Munsoo Lee, Dabin Park, Il-Ho Lee, Sang Hag Kim, Tae Hoon Pharmaceutics Review Nasal drug delivery is advantageous when compared with other routes of drug delivery as it avoids the hepatic first-pass effect, blood–brain barrier penetration, and compliance issues with parenteral administration. However, nasal administration also has some limitations, such as its low bioavailability due to metabolism on the mucosal surface, and irreversible damage to the nasal mucosa due to the ingredients added into the formula. Moreover, the method of nasal administration is not applicable to all drugs. The current review presents the nasal anatomy and mucosal environment for the nasal delivery of vaccines and drugs, as well as presents various methods for enhancing nasal absorption, and different drug carriers and delivery devices to improve nasal drug delivery. It also presents future prospects on the nasal drug delivery of vaccines and drugs. MDPI 2022-05-17 /pmc/articles/PMC9144811/ /pubmed/35631663 http://dx.doi.org/10.3390/pharmaceutics14051073 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tai, Junhu Han, Munsoo Lee, Dabin Park, Il-Ho Lee, Sang Hag Kim, Tae Hoon Different Methods and Formulations of Drugs and Vaccines for Nasal Administration |
title | Different Methods and Formulations of Drugs and Vaccines for Nasal Administration |
title_full | Different Methods and Formulations of Drugs and Vaccines for Nasal Administration |
title_fullStr | Different Methods and Formulations of Drugs and Vaccines for Nasal Administration |
title_full_unstemmed | Different Methods and Formulations of Drugs and Vaccines for Nasal Administration |
title_short | Different Methods and Formulations of Drugs and Vaccines for Nasal Administration |
title_sort | different methods and formulations of drugs and vaccines for nasal administration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144811/ https://www.ncbi.nlm.nih.gov/pubmed/35631663 http://dx.doi.org/10.3390/pharmaceutics14051073 |
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