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SBRT for Localized Prostate Cancer: CyberKnife vs. VMAT-FFF, a Dosimetric Study

In recent years, stereotactic body radiation therapy (SBRT) has gained popularity among clinical methods for the treatment of medium and low risk prostate cancer (PCa), mainly as an alternative to surgery. The hypo-fractionated regimen allows the administration of high doses of radiation in a small...

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Autores principales: Serra, Marcello, De Martino, Fortuna, Savino, Federica, d’Alesio, Valentina, Arrichiello, Cecilia, Quarto, Maria, Loffredo, Filomena, Di Franco, Rossella, Borzillo, Valentina, Muto, Matteo, Ametrano, Gianluca, Muto, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144859/
https://www.ncbi.nlm.nih.gov/pubmed/35629378
http://dx.doi.org/10.3390/life12050711
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author Serra, Marcello
De Martino, Fortuna
Savino, Federica
d’Alesio, Valentina
Arrichiello, Cecilia
Quarto, Maria
Loffredo, Filomena
Di Franco, Rossella
Borzillo, Valentina
Muto, Matteo
Ametrano, Gianluca
Muto, Paolo
author_facet Serra, Marcello
De Martino, Fortuna
Savino, Federica
d’Alesio, Valentina
Arrichiello, Cecilia
Quarto, Maria
Loffredo, Filomena
Di Franco, Rossella
Borzillo, Valentina
Muto, Matteo
Ametrano, Gianluca
Muto, Paolo
author_sort Serra, Marcello
collection PubMed
description In recent years, stereotactic body radiation therapy (SBRT) has gained popularity among clinical methods for the treatment of medium and low risk prostate cancer (PCa), mainly as an alternative to surgery. The hypo-fractionated regimen allows the administration of high doses of radiation in a small number of fractions; such a fractionation is possible by exploiting the different intrinsic prostate radiosensitivity compared with the surrounding healthy tissues. In addition, SBRT treatment guaranteed a better quality of life compared with surgery, avoiding risks, aftermaths, and possible complications. At present, most stereotactic prostate treatments are performed with the CyberKnife (CK) system, which is an accelerator exclusively dedicated for stereotaxis and it is not widely spread in every radiotherapy centre like a classic linear accelerator (LINAC). To be fair, a stereotactic treatment is achievable also by using a LINAC through Volumetric Modulated Arc Therapy (VMAT), but some precautions must be taken. The aim of this work is to carry out a dosimetric comparison between these two methodologies. In order to pursue such a goal, two groups of patients were selected at Instituto Nazionale Tumori—IRCCS Fondazione G. Pascale: the first group consisting of ten patients previously treated with a SBRT performed with CK; the second one was composed of ten patients who received a hypo-fractionated VMAT treatment and replanned in VMAT-SBRT flattening filter free mode (FFF). The two SBRT techniques were rescaled at the same target coverage and compared by normal tissue sparing, dose distribution parameters and delivery time. All organs at risk (OAR) constraints were achieved by both platforms. CK exhibits higher performances in terms of dose delivery; nevertheless, the general satisfying dosimetric results and the significantly shorter delivery time make VMAT-FFF an attractive and reasonable alternative SBRT technique for the treatment of localized prostate cancer.
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spelling pubmed-91448592022-05-29 SBRT for Localized Prostate Cancer: CyberKnife vs. VMAT-FFF, a Dosimetric Study Serra, Marcello De Martino, Fortuna Savino, Federica d’Alesio, Valentina Arrichiello, Cecilia Quarto, Maria Loffredo, Filomena Di Franco, Rossella Borzillo, Valentina Muto, Matteo Ametrano, Gianluca Muto, Paolo Life (Basel) Article In recent years, stereotactic body radiation therapy (SBRT) has gained popularity among clinical methods for the treatment of medium and low risk prostate cancer (PCa), mainly as an alternative to surgery. The hypo-fractionated regimen allows the administration of high doses of radiation in a small number of fractions; such a fractionation is possible by exploiting the different intrinsic prostate radiosensitivity compared with the surrounding healthy tissues. In addition, SBRT treatment guaranteed a better quality of life compared with surgery, avoiding risks, aftermaths, and possible complications. At present, most stereotactic prostate treatments are performed with the CyberKnife (CK) system, which is an accelerator exclusively dedicated for stereotaxis and it is not widely spread in every radiotherapy centre like a classic linear accelerator (LINAC). To be fair, a stereotactic treatment is achievable also by using a LINAC through Volumetric Modulated Arc Therapy (VMAT), but some precautions must be taken. The aim of this work is to carry out a dosimetric comparison between these two methodologies. In order to pursue such a goal, two groups of patients were selected at Instituto Nazionale Tumori—IRCCS Fondazione G. Pascale: the first group consisting of ten patients previously treated with a SBRT performed with CK; the second one was composed of ten patients who received a hypo-fractionated VMAT treatment and replanned in VMAT-SBRT flattening filter free mode (FFF). The two SBRT techniques were rescaled at the same target coverage and compared by normal tissue sparing, dose distribution parameters and delivery time. All organs at risk (OAR) constraints were achieved by both platforms. CK exhibits higher performances in terms of dose delivery; nevertheless, the general satisfying dosimetric results and the significantly shorter delivery time make VMAT-FFF an attractive and reasonable alternative SBRT technique for the treatment of localized prostate cancer. MDPI 2022-05-10 /pmc/articles/PMC9144859/ /pubmed/35629378 http://dx.doi.org/10.3390/life12050711 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Serra, Marcello
De Martino, Fortuna
Savino, Federica
d’Alesio, Valentina
Arrichiello, Cecilia
Quarto, Maria
Loffredo, Filomena
Di Franco, Rossella
Borzillo, Valentina
Muto, Matteo
Ametrano, Gianluca
Muto, Paolo
SBRT for Localized Prostate Cancer: CyberKnife vs. VMAT-FFF, a Dosimetric Study
title SBRT for Localized Prostate Cancer: CyberKnife vs. VMAT-FFF, a Dosimetric Study
title_full SBRT for Localized Prostate Cancer: CyberKnife vs. VMAT-FFF, a Dosimetric Study
title_fullStr SBRT for Localized Prostate Cancer: CyberKnife vs. VMAT-FFF, a Dosimetric Study
title_full_unstemmed SBRT for Localized Prostate Cancer: CyberKnife vs. VMAT-FFF, a Dosimetric Study
title_short SBRT for Localized Prostate Cancer: CyberKnife vs. VMAT-FFF, a Dosimetric Study
title_sort sbrt for localized prostate cancer: cyberknife vs. vmat-fff, a dosimetric study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144859/
https://www.ncbi.nlm.nih.gov/pubmed/35629378
http://dx.doi.org/10.3390/life12050711
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