Cargando…

Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome

The clinical characteristics and the effect of viral RNA loads on fatality in 56 patients with severe fever with thrombocytopenia syndrome (SFTS) were analyzed. The non-survival group (12 patients) demonstrated a significantly higher mean age (77 years) than the survival group (44 patients, 65 years...

Descripción completa

Detalles Bibliográficos
Autores principales: Jo, Heyon-Na, Kim, Jieun, Hwang, Seong-Yeon, Seo, Jun-Won, Kim, Da Young, Yun, Na-Ra, Kim, Dong-Min, Kim, Choon-Mee, Jung, Sook In, Kim, Uh Jin, Kim, Seong Eun, Kim, Hyunah, Kim, Eu Suk, Hur, Jian, Kim, Young Keun, Jeong, Hye Won, Heo, Jung Yeon, Jung, Dong Sik, Lee, Hyungdon, Park, Sun Hee, Kwak, Yee Gyung, Lee, Sujin, Lim, Seungjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144926/
https://www.ncbi.nlm.nih.gov/pubmed/35632623
http://dx.doi.org/10.3390/v14050881
_version_ 1784716167443644416
author Jo, Heyon-Na
Kim, Jieun
Hwang, Seong-Yeon
Seo, Jun-Won
Kim, Da Young
Yun, Na-Ra
Kim, Dong-Min
Kim, Choon-Mee
Jung, Sook In
Kim, Uh Jin
Kim, Seong Eun
Kim, Hyunah
Kim, Eu Suk
Hur, Jian
Kim, Young Keun
Jeong, Hye Won
Heo, Jung Yeon
Jung, Dong Sik
Lee, Hyungdon
Park, Sun Hee
Kwak, Yee Gyung
Lee, Sujin
Lim, Seungjin
author_facet Jo, Heyon-Na
Kim, Jieun
Hwang, Seong-Yeon
Seo, Jun-Won
Kim, Da Young
Yun, Na-Ra
Kim, Dong-Min
Kim, Choon-Mee
Jung, Sook In
Kim, Uh Jin
Kim, Seong Eun
Kim, Hyunah
Kim, Eu Suk
Hur, Jian
Kim, Young Keun
Jeong, Hye Won
Heo, Jung Yeon
Jung, Dong Sik
Lee, Hyungdon
Park, Sun Hee
Kwak, Yee Gyung
Lee, Sujin
Lim, Seungjin
author_sort Jo, Heyon-Na
collection PubMed
description The clinical characteristics and the effect of viral RNA loads on fatality in 56 patients with severe fever with thrombocytopenia syndrome (SFTS) were analyzed. The non-survival group (12 patients) demonstrated a significantly higher mean age (77 years) than the survival group (44 patients, 65 years) (p = 0.003). The survival rates were 91.7% and 8.3% in patients with Ct values ≥30 and differed significantly (p = 0.001) in the survival and non-survival groups, respectively. The survival rates were 52.4% and 47.6% in patients with viral copy numbers ≥10,000 and 94.3% and 5.7% in patients with viral copy numbers <10,000 in the survival and non-survival groups, respectively (p = 0.001). In a multivariate analysis, viral copy numbers and initial Acute Psychologic Assessment and Chronic Health Evaluation II (APACHE II) scores were identified as the factors affecting fatality (p = 0.015 and 0.011, respectively). SFTS viral RNA loads can be useful markers for the clinical prediction of mortality and survival.
format Online
Article
Text
id pubmed-9144926
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91449262022-05-29 Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome Jo, Heyon-Na Kim, Jieun Hwang, Seong-Yeon Seo, Jun-Won Kim, Da Young Yun, Na-Ra Kim, Dong-Min Kim, Choon-Mee Jung, Sook In Kim, Uh Jin Kim, Seong Eun Kim, Hyunah Kim, Eu Suk Hur, Jian Kim, Young Keun Jeong, Hye Won Heo, Jung Yeon Jung, Dong Sik Lee, Hyungdon Park, Sun Hee Kwak, Yee Gyung Lee, Sujin Lim, Seungjin Viruses Article The clinical characteristics and the effect of viral RNA loads on fatality in 56 patients with severe fever with thrombocytopenia syndrome (SFTS) were analyzed. The non-survival group (12 patients) demonstrated a significantly higher mean age (77 years) than the survival group (44 patients, 65 years) (p = 0.003). The survival rates were 91.7% and 8.3% in patients with Ct values ≥30 and differed significantly (p = 0.001) in the survival and non-survival groups, respectively. The survival rates were 52.4% and 47.6% in patients with viral copy numbers ≥10,000 and 94.3% and 5.7% in patients with viral copy numbers <10,000 in the survival and non-survival groups, respectively (p = 0.001). In a multivariate analysis, viral copy numbers and initial Acute Psychologic Assessment and Chronic Health Evaluation II (APACHE II) scores were identified as the factors affecting fatality (p = 0.015 and 0.011, respectively). SFTS viral RNA loads can be useful markers for the clinical prediction of mortality and survival. MDPI 2022-04-23 /pmc/articles/PMC9144926/ /pubmed/35632623 http://dx.doi.org/10.3390/v14050881 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jo, Heyon-Na
Kim, Jieun
Hwang, Seong-Yeon
Seo, Jun-Won
Kim, Da Young
Yun, Na-Ra
Kim, Dong-Min
Kim, Choon-Mee
Jung, Sook In
Kim, Uh Jin
Kim, Seong Eun
Kim, Hyunah
Kim, Eu Suk
Hur, Jian
Kim, Young Keun
Jeong, Hye Won
Heo, Jung Yeon
Jung, Dong Sik
Lee, Hyungdon
Park, Sun Hee
Kwak, Yee Gyung
Lee, Sujin
Lim, Seungjin
Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome
title Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome
title_full Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome
title_fullStr Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome
title_full_unstemmed Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome
title_short Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome
title_sort viral load as a factor affecting the fatality of patients suffering from severe fever with thrombocytopenia syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144926/
https://www.ncbi.nlm.nih.gov/pubmed/35632623
http://dx.doi.org/10.3390/v14050881
work_keys_str_mv AT joheyonna viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT kimjieun viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT hwangseongyeon viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT seojunwon viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT kimdayoung viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT yunnara viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT kimdongmin viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT kimchoonmee viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT jungsookin viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT kimuhjin viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT kimseongeun viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT kimhyunah viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT kimeusuk viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT hurjian viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT kimyoungkeun viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT jeonghyewon viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT heojungyeon viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT jungdongsik viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT leehyungdon viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT parksunhee viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT kwakyeegyung viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT leesujin viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT limseungjin viralloadasafactoraffectingthefatalityofpatientssufferingfromseverefeverwiththrombocytopeniasyndrome