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Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome
The clinical characteristics and the effect of viral RNA loads on fatality in 56 patients with severe fever with thrombocytopenia syndrome (SFTS) were analyzed. The non-survival group (12 patients) demonstrated a significantly higher mean age (77 years) than the survival group (44 patients, 65 years...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144926/ https://www.ncbi.nlm.nih.gov/pubmed/35632623 http://dx.doi.org/10.3390/v14050881 |
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author | Jo, Heyon-Na Kim, Jieun Hwang, Seong-Yeon Seo, Jun-Won Kim, Da Young Yun, Na-Ra Kim, Dong-Min Kim, Choon-Mee Jung, Sook In Kim, Uh Jin Kim, Seong Eun Kim, Hyunah Kim, Eu Suk Hur, Jian Kim, Young Keun Jeong, Hye Won Heo, Jung Yeon Jung, Dong Sik Lee, Hyungdon Park, Sun Hee Kwak, Yee Gyung Lee, Sujin Lim, Seungjin |
author_facet | Jo, Heyon-Na Kim, Jieun Hwang, Seong-Yeon Seo, Jun-Won Kim, Da Young Yun, Na-Ra Kim, Dong-Min Kim, Choon-Mee Jung, Sook In Kim, Uh Jin Kim, Seong Eun Kim, Hyunah Kim, Eu Suk Hur, Jian Kim, Young Keun Jeong, Hye Won Heo, Jung Yeon Jung, Dong Sik Lee, Hyungdon Park, Sun Hee Kwak, Yee Gyung Lee, Sujin Lim, Seungjin |
author_sort | Jo, Heyon-Na |
collection | PubMed |
description | The clinical characteristics and the effect of viral RNA loads on fatality in 56 patients with severe fever with thrombocytopenia syndrome (SFTS) were analyzed. The non-survival group (12 patients) demonstrated a significantly higher mean age (77 years) than the survival group (44 patients, 65 years) (p = 0.003). The survival rates were 91.7% and 8.3% in patients with Ct values ≥30 and differed significantly (p = 0.001) in the survival and non-survival groups, respectively. The survival rates were 52.4% and 47.6% in patients with viral copy numbers ≥10,000 and 94.3% and 5.7% in patients with viral copy numbers <10,000 in the survival and non-survival groups, respectively (p = 0.001). In a multivariate analysis, viral copy numbers and initial Acute Psychologic Assessment and Chronic Health Evaluation II (APACHE II) scores were identified as the factors affecting fatality (p = 0.015 and 0.011, respectively). SFTS viral RNA loads can be useful markers for the clinical prediction of mortality and survival. |
format | Online Article Text |
id | pubmed-9144926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91449262022-05-29 Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome Jo, Heyon-Na Kim, Jieun Hwang, Seong-Yeon Seo, Jun-Won Kim, Da Young Yun, Na-Ra Kim, Dong-Min Kim, Choon-Mee Jung, Sook In Kim, Uh Jin Kim, Seong Eun Kim, Hyunah Kim, Eu Suk Hur, Jian Kim, Young Keun Jeong, Hye Won Heo, Jung Yeon Jung, Dong Sik Lee, Hyungdon Park, Sun Hee Kwak, Yee Gyung Lee, Sujin Lim, Seungjin Viruses Article The clinical characteristics and the effect of viral RNA loads on fatality in 56 patients with severe fever with thrombocytopenia syndrome (SFTS) were analyzed. The non-survival group (12 patients) demonstrated a significantly higher mean age (77 years) than the survival group (44 patients, 65 years) (p = 0.003). The survival rates were 91.7% and 8.3% in patients with Ct values ≥30 and differed significantly (p = 0.001) in the survival and non-survival groups, respectively. The survival rates were 52.4% and 47.6% in patients with viral copy numbers ≥10,000 and 94.3% and 5.7% in patients with viral copy numbers <10,000 in the survival and non-survival groups, respectively (p = 0.001). In a multivariate analysis, viral copy numbers and initial Acute Psychologic Assessment and Chronic Health Evaluation II (APACHE II) scores were identified as the factors affecting fatality (p = 0.015 and 0.011, respectively). SFTS viral RNA loads can be useful markers for the clinical prediction of mortality and survival. MDPI 2022-04-23 /pmc/articles/PMC9144926/ /pubmed/35632623 http://dx.doi.org/10.3390/v14050881 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jo, Heyon-Na Kim, Jieun Hwang, Seong-Yeon Seo, Jun-Won Kim, Da Young Yun, Na-Ra Kim, Dong-Min Kim, Choon-Mee Jung, Sook In Kim, Uh Jin Kim, Seong Eun Kim, Hyunah Kim, Eu Suk Hur, Jian Kim, Young Keun Jeong, Hye Won Heo, Jung Yeon Jung, Dong Sik Lee, Hyungdon Park, Sun Hee Kwak, Yee Gyung Lee, Sujin Lim, Seungjin Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome |
title | Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome |
title_full | Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome |
title_fullStr | Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome |
title_full_unstemmed | Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome |
title_short | Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome |
title_sort | viral load as a factor affecting the fatality of patients suffering from severe fever with thrombocytopenia syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144926/ https://www.ncbi.nlm.nih.gov/pubmed/35632623 http://dx.doi.org/10.3390/v14050881 |
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