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Laser Synthesized Core-Satellite Fe-Au Nanoparticles for Multimodal In Vivo Imaging and In Vitro Photothermal Therapy

Hybrid multimodal nanoparticles, applicable simultaneously to the noninvasive imaging and therapeutic treatment, are highly demanded for clinical use. Here, Fe-Au core-satellite nanoparticles prepared by the method of pulsed laser ablation in liquids were evaluated as dual magnetic resonance imaging...

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Autores principales: Griaznova, Olga Yu., Belyaev, Iaroslav B., Sogomonyan, Anna S., Zelepukin, Ivan V., Tikhonowski, Gleb V., Popov, Anton A., Komlev, Aleksei S., Nikitin, Petr I., Gorin, Dmitry A., Kabashin, Andrei V., Deyev, Sergey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144942/
https://www.ncbi.nlm.nih.gov/pubmed/35631580
http://dx.doi.org/10.3390/pharmaceutics14050994
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author Griaznova, Olga Yu.
Belyaev, Iaroslav B.
Sogomonyan, Anna S.
Zelepukin, Ivan V.
Tikhonowski, Gleb V.
Popov, Anton A.
Komlev, Aleksei S.
Nikitin, Petr I.
Gorin, Dmitry A.
Kabashin, Andrei V.
Deyev, Sergey M.
author_facet Griaznova, Olga Yu.
Belyaev, Iaroslav B.
Sogomonyan, Anna S.
Zelepukin, Ivan V.
Tikhonowski, Gleb V.
Popov, Anton A.
Komlev, Aleksei S.
Nikitin, Petr I.
Gorin, Dmitry A.
Kabashin, Andrei V.
Deyev, Sergey M.
author_sort Griaznova, Olga Yu.
collection PubMed
description Hybrid multimodal nanoparticles, applicable simultaneously to the noninvasive imaging and therapeutic treatment, are highly demanded for clinical use. Here, Fe-Au core-satellite nanoparticles prepared by the method of pulsed laser ablation in liquids were evaluated as dual magnetic resonance imaging (MRI) and computed tomography (CT) contrast agents and as sensitizers for laser-induced hyperthermia of cancer cells. The biocompatibility of Fe-Au nanoparticles was improved by coating with polyacrylic acid, which provided excellent colloidal stability of nanoparticles with highly negative ζ-potential in water (−38 ± 7 mV) and retained hydrodynamic size (88 ± 20 nm) in a physiological environment. The ferromagnetic iron cores offered great contrast in MRI images with r(2) = 11.8 ± 0.8 mM(−1) s(−1) (at 1 T), while Au satellites showed X-ray attenuation in CT. The intravenous injection of nanoparticles enabled clear tumor border visualization in mice. Plasmonic peak in the Fe-Au hybrids had a tail in the near-infrared region (NIR), allowing them to cause hyperthermia under 808 nm laser exposure. Under NIR irradiation Fe-Au particles provided 24.1 °C/W heating and an IC(50) value below 32 µg/mL for three different cancer cell lines. Taken together, these results show that laser synthesized Fe-Au core-satellite nanoparticles are excellent theranostic agents with multimodal imaging and photothermal capabilities.
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spelling pubmed-91449422022-05-29 Laser Synthesized Core-Satellite Fe-Au Nanoparticles for Multimodal In Vivo Imaging and In Vitro Photothermal Therapy Griaznova, Olga Yu. Belyaev, Iaroslav B. Sogomonyan, Anna S. Zelepukin, Ivan V. Tikhonowski, Gleb V. Popov, Anton A. Komlev, Aleksei S. Nikitin, Petr I. Gorin, Dmitry A. Kabashin, Andrei V. Deyev, Sergey M. Pharmaceutics Article Hybrid multimodal nanoparticles, applicable simultaneously to the noninvasive imaging and therapeutic treatment, are highly demanded for clinical use. Here, Fe-Au core-satellite nanoparticles prepared by the method of pulsed laser ablation in liquids were evaluated as dual magnetic resonance imaging (MRI) and computed tomography (CT) contrast agents and as sensitizers for laser-induced hyperthermia of cancer cells. The biocompatibility of Fe-Au nanoparticles was improved by coating with polyacrylic acid, which provided excellent colloidal stability of nanoparticles with highly negative ζ-potential in water (−38 ± 7 mV) and retained hydrodynamic size (88 ± 20 nm) in a physiological environment. The ferromagnetic iron cores offered great contrast in MRI images with r(2) = 11.8 ± 0.8 mM(−1) s(−1) (at 1 T), while Au satellites showed X-ray attenuation in CT. The intravenous injection of nanoparticles enabled clear tumor border visualization in mice. Plasmonic peak in the Fe-Au hybrids had a tail in the near-infrared region (NIR), allowing them to cause hyperthermia under 808 nm laser exposure. Under NIR irradiation Fe-Au particles provided 24.1 °C/W heating and an IC(50) value below 32 µg/mL for three different cancer cell lines. Taken together, these results show that laser synthesized Fe-Au core-satellite nanoparticles are excellent theranostic agents with multimodal imaging and photothermal capabilities. MDPI 2022-05-05 /pmc/articles/PMC9144942/ /pubmed/35631580 http://dx.doi.org/10.3390/pharmaceutics14050994 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Griaznova, Olga Yu.
Belyaev, Iaroslav B.
Sogomonyan, Anna S.
Zelepukin, Ivan V.
Tikhonowski, Gleb V.
Popov, Anton A.
Komlev, Aleksei S.
Nikitin, Petr I.
Gorin, Dmitry A.
Kabashin, Andrei V.
Deyev, Sergey M.
Laser Synthesized Core-Satellite Fe-Au Nanoparticles for Multimodal In Vivo Imaging and In Vitro Photothermal Therapy
title Laser Synthesized Core-Satellite Fe-Au Nanoparticles for Multimodal In Vivo Imaging and In Vitro Photothermal Therapy
title_full Laser Synthesized Core-Satellite Fe-Au Nanoparticles for Multimodal In Vivo Imaging and In Vitro Photothermal Therapy
title_fullStr Laser Synthesized Core-Satellite Fe-Au Nanoparticles for Multimodal In Vivo Imaging and In Vitro Photothermal Therapy
title_full_unstemmed Laser Synthesized Core-Satellite Fe-Au Nanoparticles for Multimodal In Vivo Imaging and In Vitro Photothermal Therapy
title_short Laser Synthesized Core-Satellite Fe-Au Nanoparticles for Multimodal In Vivo Imaging and In Vitro Photothermal Therapy
title_sort laser synthesized core-satellite fe-au nanoparticles for multimodal in vivo imaging and in vitro photothermal therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144942/
https://www.ncbi.nlm.nih.gov/pubmed/35631580
http://dx.doi.org/10.3390/pharmaceutics14050994
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