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Decadal Change in Seroprevalence of Chikungunya Virus Infection in Pune City, India

Chikungunya virus (CHIKV) is an arthropod-borne virus capable of causing large outbreaks. We aimed to determine the decadal change in the extent of chikungunya virus infection from 2009 to 2019. We implemented a prospective cross-sectional survey in Pune City using a 30-cluster approach with probabi...

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Autores principales: Tomar, Shilpa Jagatram, Alagarasu, Kalichamy, More, Ashwini, Nadkarni, Manasi, Bachal, Rupali, Bote, Minal, Patil, Jayashri, Venkatesh, Vasanthy, Parashar, Deepti, Tandale, Babasaheb Vishwanath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144945/
https://www.ncbi.nlm.nih.gov/pubmed/35632740
http://dx.doi.org/10.3390/v14050998
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author Tomar, Shilpa Jagatram
Alagarasu, Kalichamy
More, Ashwini
Nadkarni, Manasi
Bachal, Rupali
Bote, Minal
Patil, Jayashri
Venkatesh, Vasanthy
Parashar, Deepti
Tandale, Babasaheb Vishwanath
author_facet Tomar, Shilpa Jagatram
Alagarasu, Kalichamy
More, Ashwini
Nadkarni, Manasi
Bachal, Rupali
Bote, Minal
Patil, Jayashri
Venkatesh, Vasanthy
Parashar, Deepti
Tandale, Babasaheb Vishwanath
author_sort Tomar, Shilpa Jagatram
collection PubMed
description Chikungunya virus (CHIKV) is an arthropod-borne virus capable of causing large outbreaks. We aimed to determine the decadal change in the extent of chikungunya virus infection from 2009 to 2019. We implemented a prospective cross-sectional survey in Pune City using a 30-cluster approach with probability-proportion-to-size (PPS) sampling, with blood samples collected from 1654 participants in early 2019. The study also included an additional 799 blood samples from an earlier serosurvey in late 2009. The samples were tested by an in-house anti-CHIKV IgG ELISA assay. The overall seroprevalence in 2019 was 53.2% (95% CI 50.7–55.6) as against 8.5% (95% CI 6.5–10.4) in 2009. A fivefold increase in seroprevalence was observed in a decade (p < 0.00001). The seroprevalence increased significantly with age; however, it did not differ between genders. Modeling of age-stratified seroprevalence data from 2019 coincided with a recent outbreak in 2016 followed by the low-level circulation. The mean estimated force of infection during the outbreak was 35.8% (95% CI 2.9–41.2), and it was 1.2% after the outbreak. To conclude, the study reports a fivefold increase in the seroprevalence of chikungunya infection over a decade in Pune City. The modeling approach considering intermittent outbreaks with continuous low-level circulation was a better fit and coincided with a recent outbreak reported in 2016. Community engagement and effective vector control measures are needed to avert future chikungunya outbreaks.
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spelling pubmed-91449452022-05-29 Decadal Change in Seroprevalence of Chikungunya Virus Infection in Pune City, India Tomar, Shilpa Jagatram Alagarasu, Kalichamy More, Ashwini Nadkarni, Manasi Bachal, Rupali Bote, Minal Patil, Jayashri Venkatesh, Vasanthy Parashar, Deepti Tandale, Babasaheb Vishwanath Viruses Article Chikungunya virus (CHIKV) is an arthropod-borne virus capable of causing large outbreaks. We aimed to determine the decadal change in the extent of chikungunya virus infection from 2009 to 2019. We implemented a prospective cross-sectional survey in Pune City using a 30-cluster approach with probability-proportion-to-size (PPS) sampling, with blood samples collected from 1654 participants in early 2019. The study also included an additional 799 blood samples from an earlier serosurvey in late 2009. The samples were tested by an in-house anti-CHIKV IgG ELISA assay. The overall seroprevalence in 2019 was 53.2% (95% CI 50.7–55.6) as against 8.5% (95% CI 6.5–10.4) in 2009. A fivefold increase in seroprevalence was observed in a decade (p < 0.00001). The seroprevalence increased significantly with age; however, it did not differ between genders. Modeling of age-stratified seroprevalence data from 2019 coincided with a recent outbreak in 2016 followed by the low-level circulation. The mean estimated force of infection during the outbreak was 35.8% (95% CI 2.9–41.2), and it was 1.2% after the outbreak. To conclude, the study reports a fivefold increase in the seroprevalence of chikungunya infection over a decade in Pune City. The modeling approach considering intermittent outbreaks with continuous low-level circulation was a better fit and coincided with a recent outbreak reported in 2016. Community engagement and effective vector control measures are needed to avert future chikungunya outbreaks. MDPI 2022-05-07 /pmc/articles/PMC9144945/ /pubmed/35632740 http://dx.doi.org/10.3390/v14050998 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tomar, Shilpa Jagatram
Alagarasu, Kalichamy
More, Ashwini
Nadkarni, Manasi
Bachal, Rupali
Bote, Minal
Patil, Jayashri
Venkatesh, Vasanthy
Parashar, Deepti
Tandale, Babasaheb Vishwanath
Decadal Change in Seroprevalence of Chikungunya Virus Infection in Pune City, India
title Decadal Change in Seroprevalence of Chikungunya Virus Infection in Pune City, India
title_full Decadal Change in Seroprevalence of Chikungunya Virus Infection in Pune City, India
title_fullStr Decadal Change in Seroprevalence of Chikungunya Virus Infection in Pune City, India
title_full_unstemmed Decadal Change in Seroprevalence of Chikungunya Virus Infection in Pune City, India
title_short Decadal Change in Seroprevalence of Chikungunya Virus Infection in Pune City, India
title_sort decadal change in seroprevalence of chikungunya virus infection in pune city, india
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144945/
https://www.ncbi.nlm.nih.gov/pubmed/35632740
http://dx.doi.org/10.3390/v14050998
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