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A Prospective Study of Fruit Juice Consumption and the Risk of Overall and Cardiovascular Disease Mortality

There is little evidence for the association between fruit juice, especially 100% fruit juice, and mortality risk. In addition, whether 100% fruit juice can be a healthy alternative to whole fruit remains uncertain. This prospective study utilized the data from the US National Health and Nutrition E...

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Autores principales: Zhang, Zhuang, Zeng, Xueke, Li, Meiling, Zhang, Tengfei, Li, Haowei, Yang, Hu, Huang, Yong, Zhu, Yu, Li, Xiude, Yang, Wanshui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144949/
https://www.ncbi.nlm.nih.gov/pubmed/35631268
http://dx.doi.org/10.3390/nu14102127
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author Zhang, Zhuang
Zeng, Xueke
Li, Meiling
Zhang, Tengfei
Li, Haowei
Yang, Hu
Huang, Yong
Zhu, Yu
Li, Xiude
Yang, Wanshui
author_facet Zhang, Zhuang
Zeng, Xueke
Li, Meiling
Zhang, Tengfei
Li, Haowei
Yang, Hu
Huang, Yong
Zhu, Yu
Li, Xiude
Yang, Wanshui
author_sort Zhang, Zhuang
collection PubMed
description There is little evidence for the association between fruit juice, especially 100% fruit juice, and mortality risk. In addition, whether 100% fruit juice can be a healthy alternative to whole fruit remains uncertain. This prospective study utilized the data from the US National Health and Nutrition Examination Survey (NHANES) from 1999 to 2014. After a median follow-up of 7.8 years, 4904 deaths among 40,074 participants aged 18 years or older were documented. Compared to non-consumption, daily consumption of 250 g or more of 100% fruit juice was associated with higher overall mortality (hazard ratio (HR) = 1.30, 95% confidence interval (CI): 1.11–1.52) and mortality from heart disease (HR = 1.49, 95 CI: 1.01–2.21). A similar pattern was observed for total fruit juice, with HRs of 1.28 (95% CI: 1.09–1.49) for overall mortality and 1.48 (95% CI: 1.01–2.17) for heart disease mortality. Replacing 5% of energy from whole fruit with 100% or total fruit juice was associated with a 9% (95% CI: 2–16%) and 8% (95% CI: 1–15%) increased mortality risk, respectively. Our findings suggest that both total and 100% fruit juice could be associated with high mortality risk, and need to be validated in well-designed studies given the potential misclassification of diet and death reasons.
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spelling pubmed-91449492022-05-29 A Prospective Study of Fruit Juice Consumption and the Risk of Overall and Cardiovascular Disease Mortality Zhang, Zhuang Zeng, Xueke Li, Meiling Zhang, Tengfei Li, Haowei Yang, Hu Huang, Yong Zhu, Yu Li, Xiude Yang, Wanshui Nutrients Article There is little evidence for the association between fruit juice, especially 100% fruit juice, and mortality risk. In addition, whether 100% fruit juice can be a healthy alternative to whole fruit remains uncertain. This prospective study utilized the data from the US National Health and Nutrition Examination Survey (NHANES) from 1999 to 2014. After a median follow-up of 7.8 years, 4904 deaths among 40,074 participants aged 18 years or older were documented. Compared to non-consumption, daily consumption of 250 g or more of 100% fruit juice was associated with higher overall mortality (hazard ratio (HR) = 1.30, 95% confidence interval (CI): 1.11–1.52) and mortality from heart disease (HR = 1.49, 95 CI: 1.01–2.21). A similar pattern was observed for total fruit juice, with HRs of 1.28 (95% CI: 1.09–1.49) for overall mortality and 1.48 (95% CI: 1.01–2.17) for heart disease mortality. Replacing 5% of energy from whole fruit with 100% or total fruit juice was associated with a 9% (95% CI: 2–16%) and 8% (95% CI: 1–15%) increased mortality risk, respectively. Our findings suggest that both total and 100% fruit juice could be associated with high mortality risk, and need to be validated in well-designed studies given the potential misclassification of diet and death reasons. MDPI 2022-05-19 /pmc/articles/PMC9144949/ /pubmed/35631268 http://dx.doi.org/10.3390/nu14102127 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Zhuang
Zeng, Xueke
Li, Meiling
Zhang, Tengfei
Li, Haowei
Yang, Hu
Huang, Yong
Zhu, Yu
Li, Xiude
Yang, Wanshui
A Prospective Study of Fruit Juice Consumption and the Risk of Overall and Cardiovascular Disease Mortality
title A Prospective Study of Fruit Juice Consumption and the Risk of Overall and Cardiovascular Disease Mortality
title_full A Prospective Study of Fruit Juice Consumption and the Risk of Overall and Cardiovascular Disease Mortality
title_fullStr A Prospective Study of Fruit Juice Consumption and the Risk of Overall and Cardiovascular Disease Mortality
title_full_unstemmed A Prospective Study of Fruit Juice Consumption and the Risk of Overall and Cardiovascular Disease Mortality
title_short A Prospective Study of Fruit Juice Consumption and the Risk of Overall and Cardiovascular Disease Mortality
title_sort prospective study of fruit juice consumption and the risk of overall and cardiovascular disease mortality
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144949/
https://www.ncbi.nlm.nih.gov/pubmed/35631268
http://dx.doi.org/10.3390/nu14102127
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