Cargando…
Extra Virgin Olive Oil Reduces Gut Permeability and Metabolic Endotoxemia in Diabetic Patients
Background: Extra virgin olive oil (EVOO) improves post-prandial glycemia, but the underlying mechanism has not been fully elucidated. We tested the hypothesis that EVOO improves post-prandial glycemia by reducing gut permeability-derived low-grade endotoxemia. Methods: Serum levels of lipopolysacch...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145083/ https://www.ncbi.nlm.nih.gov/pubmed/35631294 http://dx.doi.org/10.3390/nu14102153 |
_version_ | 1784716206254587904 |
---|---|
author | Bartimoccia, Simona Cammisotto, Vittoria Nocella, Cristina Del Ben, Maria D’Amico, Alessandra Castellani, Valentina Baratta, Francesco Pignatelli, Pasquale Loffredo, Lorenzo Violi, Francesco Carnevale, Roberto |
author_facet | Bartimoccia, Simona Cammisotto, Vittoria Nocella, Cristina Del Ben, Maria D’Amico, Alessandra Castellani, Valentina Baratta, Francesco Pignatelli, Pasquale Loffredo, Lorenzo Violi, Francesco Carnevale, Roberto |
author_sort | Bartimoccia, Simona |
collection | PubMed |
description | Background: Extra virgin olive oil (EVOO) improves post-prandial glycemia, but the underlying mechanism has not been fully elucidated. We tested the hypothesis that EVOO improves post-prandial glycemia by reducing gut permeability-derived low-grade endotoxemia. Methods: Serum levels of lipopolysaccharides (LPS), zonulin, a marker of gut permeability, glucose, insulin and glucagon-like peptide 1 (GLP1) were measured in 20 patients with impaired fasting glucose (IFG) and 20 healthy subjects (HS) matched for sex and age. The same variables were measured in IFG patients (n = 20) and HS (n = 20) before and after a Mediterranean diet with 10 g EVOO added or not (n = 20) or in IFG patients (n = 20) before and after intake of 40 g chocolate with EVOO added or not. Results: Compared to HS, IFG had higher levels of LPS and zonulin. In HS, meal intake was associated with a significant increase of blood glucose, insulin, and GLP1 with no changes of blood LPS and zonulin. Two hours after a meal intake containing EVOO, IFG patients showed a less significant increase of blood glucose, a more marked increase of blood insulin and GLP1 and a significant reduction of LPS and zonulin compared to IFG patients not given EVOO. Correlation analysis showed that LPS directly correlated with blood glucose and zonulin and inversely with blood insulin. Similar findings were detected in IFG patients given a chocolate added or without EVOO. Conclusion: Addition of EVOO to a Mediterranean diet or chocolate improves gut permeability and low-grade endotoxemia. |
format | Online Article Text |
id | pubmed-9145083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91450832022-05-29 Extra Virgin Olive Oil Reduces Gut Permeability and Metabolic Endotoxemia in Diabetic Patients Bartimoccia, Simona Cammisotto, Vittoria Nocella, Cristina Del Ben, Maria D’Amico, Alessandra Castellani, Valentina Baratta, Francesco Pignatelli, Pasquale Loffredo, Lorenzo Violi, Francesco Carnevale, Roberto Nutrients Article Background: Extra virgin olive oil (EVOO) improves post-prandial glycemia, but the underlying mechanism has not been fully elucidated. We tested the hypothesis that EVOO improves post-prandial glycemia by reducing gut permeability-derived low-grade endotoxemia. Methods: Serum levels of lipopolysaccharides (LPS), zonulin, a marker of gut permeability, glucose, insulin and glucagon-like peptide 1 (GLP1) were measured in 20 patients with impaired fasting glucose (IFG) and 20 healthy subjects (HS) matched for sex and age. The same variables were measured in IFG patients (n = 20) and HS (n = 20) before and after a Mediterranean diet with 10 g EVOO added or not (n = 20) or in IFG patients (n = 20) before and after intake of 40 g chocolate with EVOO added or not. Results: Compared to HS, IFG had higher levels of LPS and zonulin. In HS, meal intake was associated with a significant increase of blood glucose, insulin, and GLP1 with no changes of blood LPS and zonulin. Two hours after a meal intake containing EVOO, IFG patients showed a less significant increase of blood glucose, a more marked increase of blood insulin and GLP1 and a significant reduction of LPS and zonulin compared to IFG patients not given EVOO. Correlation analysis showed that LPS directly correlated with blood glucose and zonulin and inversely with blood insulin. Similar findings were detected in IFG patients given a chocolate added or without EVOO. Conclusion: Addition of EVOO to a Mediterranean diet or chocolate improves gut permeability and low-grade endotoxemia. MDPI 2022-05-21 /pmc/articles/PMC9145083/ /pubmed/35631294 http://dx.doi.org/10.3390/nu14102153 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bartimoccia, Simona Cammisotto, Vittoria Nocella, Cristina Del Ben, Maria D’Amico, Alessandra Castellani, Valentina Baratta, Francesco Pignatelli, Pasquale Loffredo, Lorenzo Violi, Francesco Carnevale, Roberto Extra Virgin Olive Oil Reduces Gut Permeability and Metabolic Endotoxemia in Diabetic Patients |
title | Extra Virgin Olive Oil Reduces Gut Permeability and Metabolic Endotoxemia in Diabetic Patients |
title_full | Extra Virgin Olive Oil Reduces Gut Permeability and Metabolic Endotoxemia in Diabetic Patients |
title_fullStr | Extra Virgin Olive Oil Reduces Gut Permeability and Metabolic Endotoxemia in Diabetic Patients |
title_full_unstemmed | Extra Virgin Olive Oil Reduces Gut Permeability and Metabolic Endotoxemia in Diabetic Patients |
title_short | Extra Virgin Olive Oil Reduces Gut Permeability and Metabolic Endotoxemia in Diabetic Patients |
title_sort | extra virgin olive oil reduces gut permeability and metabolic endotoxemia in diabetic patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145083/ https://www.ncbi.nlm.nih.gov/pubmed/35631294 http://dx.doi.org/10.3390/nu14102153 |
work_keys_str_mv | AT bartimocciasimona extravirginoliveoilreducesgutpermeabilityandmetabolicendotoxemiaindiabeticpatients AT cammisottovittoria extravirginoliveoilreducesgutpermeabilityandmetabolicendotoxemiaindiabeticpatients AT nocellacristina extravirginoliveoilreducesgutpermeabilityandmetabolicendotoxemiaindiabeticpatients AT delbenmaria extravirginoliveoilreducesgutpermeabilityandmetabolicendotoxemiaindiabeticpatients AT damicoalessandra extravirginoliveoilreducesgutpermeabilityandmetabolicendotoxemiaindiabeticpatients AT castellanivalentina extravirginoliveoilreducesgutpermeabilityandmetabolicendotoxemiaindiabeticpatients AT barattafrancesco extravirginoliveoilreducesgutpermeabilityandmetabolicendotoxemiaindiabeticpatients AT pignatellipasquale extravirginoliveoilreducesgutpermeabilityandmetabolicendotoxemiaindiabeticpatients AT loffredolorenzo extravirginoliveoilreducesgutpermeabilityandmetabolicendotoxemiaindiabeticpatients AT violifrancesco extravirginoliveoilreducesgutpermeabilityandmetabolicendotoxemiaindiabeticpatients AT carnevaleroberto extravirginoliveoilreducesgutpermeabilityandmetabolicendotoxemiaindiabeticpatients |