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Extra Virgin Olive Oil Reduces Gut Permeability and Metabolic Endotoxemia in Diabetic Patients

Background: Extra virgin olive oil (EVOO) improves post-prandial glycemia, but the underlying mechanism has not been fully elucidated. We tested the hypothesis that EVOO improves post-prandial glycemia by reducing gut permeability-derived low-grade endotoxemia. Methods: Serum levels of lipopolysacch...

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Autores principales: Bartimoccia, Simona, Cammisotto, Vittoria, Nocella, Cristina, Del Ben, Maria, D’Amico, Alessandra, Castellani, Valentina, Baratta, Francesco, Pignatelli, Pasquale, Loffredo, Lorenzo, Violi, Francesco, Carnevale, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145083/
https://www.ncbi.nlm.nih.gov/pubmed/35631294
http://dx.doi.org/10.3390/nu14102153
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author Bartimoccia, Simona
Cammisotto, Vittoria
Nocella, Cristina
Del Ben, Maria
D’Amico, Alessandra
Castellani, Valentina
Baratta, Francesco
Pignatelli, Pasquale
Loffredo, Lorenzo
Violi, Francesco
Carnevale, Roberto
author_facet Bartimoccia, Simona
Cammisotto, Vittoria
Nocella, Cristina
Del Ben, Maria
D’Amico, Alessandra
Castellani, Valentina
Baratta, Francesco
Pignatelli, Pasquale
Loffredo, Lorenzo
Violi, Francesco
Carnevale, Roberto
author_sort Bartimoccia, Simona
collection PubMed
description Background: Extra virgin olive oil (EVOO) improves post-prandial glycemia, but the underlying mechanism has not been fully elucidated. We tested the hypothesis that EVOO improves post-prandial glycemia by reducing gut permeability-derived low-grade endotoxemia. Methods: Serum levels of lipopolysaccharides (LPS), zonulin, a marker of gut permeability, glucose, insulin and glucagon-like peptide 1 (GLP1) were measured in 20 patients with impaired fasting glucose (IFG) and 20 healthy subjects (HS) matched for sex and age. The same variables were measured in IFG patients (n = 20) and HS (n = 20) before and after a Mediterranean diet with 10 g EVOO added or not (n = 20) or in IFG patients (n = 20) before and after intake of 40 g chocolate with EVOO added or not. Results: Compared to HS, IFG had higher levels of LPS and zonulin. In HS, meal intake was associated with a significant increase of blood glucose, insulin, and GLP1 with no changes of blood LPS and zonulin. Two hours after a meal intake containing EVOO, IFG patients showed a less significant increase of blood glucose, a more marked increase of blood insulin and GLP1 and a significant reduction of LPS and zonulin compared to IFG patients not given EVOO. Correlation analysis showed that LPS directly correlated with blood glucose and zonulin and inversely with blood insulin. Similar findings were detected in IFG patients given a chocolate added or without EVOO. Conclusion: Addition of EVOO to a Mediterranean diet or chocolate improves gut permeability and low-grade endotoxemia.
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spelling pubmed-91450832022-05-29 Extra Virgin Olive Oil Reduces Gut Permeability and Metabolic Endotoxemia in Diabetic Patients Bartimoccia, Simona Cammisotto, Vittoria Nocella, Cristina Del Ben, Maria D’Amico, Alessandra Castellani, Valentina Baratta, Francesco Pignatelli, Pasquale Loffredo, Lorenzo Violi, Francesco Carnevale, Roberto Nutrients Article Background: Extra virgin olive oil (EVOO) improves post-prandial glycemia, but the underlying mechanism has not been fully elucidated. We tested the hypothesis that EVOO improves post-prandial glycemia by reducing gut permeability-derived low-grade endotoxemia. Methods: Serum levels of lipopolysaccharides (LPS), zonulin, a marker of gut permeability, glucose, insulin and glucagon-like peptide 1 (GLP1) were measured in 20 patients with impaired fasting glucose (IFG) and 20 healthy subjects (HS) matched for sex and age. The same variables were measured in IFG patients (n = 20) and HS (n = 20) before and after a Mediterranean diet with 10 g EVOO added or not (n = 20) or in IFG patients (n = 20) before and after intake of 40 g chocolate with EVOO added or not. Results: Compared to HS, IFG had higher levels of LPS and zonulin. In HS, meal intake was associated with a significant increase of blood glucose, insulin, and GLP1 with no changes of blood LPS and zonulin. Two hours after a meal intake containing EVOO, IFG patients showed a less significant increase of blood glucose, a more marked increase of blood insulin and GLP1 and a significant reduction of LPS and zonulin compared to IFG patients not given EVOO. Correlation analysis showed that LPS directly correlated with blood glucose and zonulin and inversely with blood insulin. Similar findings were detected in IFG patients given a chocolate added or without EVOO. Conclusion: Addition of EVOO to a Mediterranean diet or chocolate improves gut permeability and low-grade endotoxemia. MDPI 2022-05-21 /pmc/articles/PMC9145083/ /pubmed/35631294 http://dx.doi.org/10.3390/nu14102153 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bartimoccia, Simona
Cammisotto, Vittoria
Nocella, Cristina
Del Ben, Maria
D’Amico, Alessandra
Castellani, Valentina
Baratta, Francesco
Pignatelli, Pasquale
Loffredo, Lorenzo
Violi, Francesco
Carnevale, Roberto
Extra Virgin Olive Oil Reduces Gut Permeability and Metabolic Endotoxemia in Diabetic Patients
title Extra Virgin Olive Oil Reduces Gut Permeability and Metabolic Endotoxemia in Diabetic Patients
title_full Extra Virgin Olive Oil Reduces Gut Permeability and Metabolic Endotoxemia in Diabetic Patients
title_fullStr Extra Virgin Olive Oil Reduces Gut Permeability and Metabolic Endotoxemia in Diabetic Patients
title_full_unstemmed Extra Virgin Olive Oil Reduces Gut Permeability and Metabolic Endotoxemia in Diabetic Patients
title_short Extra Virgin Olive Oil Reduces Gut Permeability and Metabolic Endotoxemia in Diabetic Patients
title_sort extra virgin olive oil reduces gut permeability and metabolic endotoxemia in diabetic patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145083/
https://www.ncbi.nlm.nih.gov/pubmed/35631294
http://dx.doi.org/10.3390/nu14102153
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