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Engineering of Escherichia coli Glyceraldehyde-3-Phosphate Dehydrogenase with Dual NAD(+)/NADP(+) Cofactor Specificity for Improving Amino Acid Production

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key enzyme in the central metabolism of microbial cells. GAPDHs differ in cofactor specificity and use NAD(+), NADP(+), or both cofactors, reducing them to NADH and NADPH, respectively. Sufficient NADPH supply is one of the critical factors requi...

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Detalles Bibliográficos
Autores principales:	Slivinskaya, Ekaterina A., Plekhanova, Natalia S., Altman, Irina B., Yampolskaya, Tatiana A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145139/ https://www.ncbi.nlm.nih.gov/pubmed/35630420 http://dx.doi.org/10.3390/microorganisms10050976

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