Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn

BACKGROUND: The noradrenergic neurons of locus coeruleus (LC) project to the spinal dorsal horn (SDH), and release norepinephrine (NE) to inhibit pain transmission. However, its effect on pathological pain and the cellular mechanism in the SDH remains unclear. This study aimed to explore the analges...

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Detalles Bibliográficos
Autores principales: Li, Juan, Wei, Yiyong, Zhou, Junli, Zou, Helin, Ma, Lulin, Liu, Chengxi, Xiao, Zhi, Liu, Xingfeng, Tan, Xinran, Yu, Tian, Cao, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145151/
https://www.ncbi.nlm.nih.gov/pubmed/35624514
http://dx.doi.org/10.1186/s12974-022-02489-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145151/
https://www.ncbi.nlm.nih.gov/pubmed/35624514
http://dx.doi.org/10.1186/s12974-022-02489-9

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