The Antileukemic and Anti-Prostatic Effect of Aeroplysinin-1 Is Mediated through ROS-Induced Apoptosis via NOX Activation and Inhibition of HIF-1a Activity

Aeroplysinin-1 is a brominated isoxazoline alkaloid that has exhibited a potent antitumor cell effect in previous reports. We evaluated the cytotoxicity of aeroplysinin-1 against leukemia and prostate cancer cells in vitro. This marine alkaloid inhibited the cell proliferation of leukemia Molt-4, K5...

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Detalles Bibliográficos
Autores principales: Shih, Shou-Ping, Lu, Mei-Chin, El-Shazly, Mohamed, Lin, Yu-Hsuan, Chen, Chun-Lin, Yu, Steve Sheng-Fa, Liu, Yi-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145196/
https://www.ncbi.nlm.nih.gov/pubmed/35629355
http://dx.doi.org/10.3390/life12050687

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