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SARS-CoV-2 Omicron Variant in Croatia—Rapid Detection of the First Case and Cross-Border Spread

Background: Due to rapid spread, the Omicron variant has become the dominant SARS-CoV-2 variant responsible for infections worldwide. We present the first detection of the Omicron variant in Croatia which resulted in rapid cross-border spreading. Methods: Whole-genome sequencing was performed using...

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Autores principales: Ferenčak, Ivana, Obrovac, Mihaela, Žmak, Ljiljana, Kuzle, Josipa, Petrović, Goranka, Vilibić-Čavlek, Tatjana, Jurić, Dragan, Jurić, Anita, Hruškar, Željka, Capak, Krunoslav, Stevanović, Vladimir, Milanović, Maja, Govedarica, Marija, Vujošević, Danijela, Tabain, Irena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145208/
https://www.ncbi.nlm.nih.gov/pubmed/35631032
http://dx.doi.org/10.3390/pathogens11050511
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author Ferenčak, Ivana
Obrovac, Mihaela
Žmak, Ljiljana
Kuzle, Josipa
Petrović, Goranka
Vilibić-Čavlek, Tatjana
Jurić, Dragan
Jurić, Anita
Hruškar, Željka
Capak, Krunoslav
Stevanović, Vladimir
Milanović, Maja
Govedarica, Marija
Vujošević, Danijela
Tabain, Irena
author_facet Ferenčak, Ivana
Obrovac, Mihaela
Žmak, Ljiljana
Kuzle, Josipa
Petrović, Goranka
Vilibić-Čavlek, Tatjana
Jurić, Dragan
Jurić, Anita
Hruškar, Željka
Capak, Krunoslav
Stevanović, Vladimir
Milanović, Maja
Govedarica, Marija
Vujošević, Danijela
Tabain, Irena
author_sort Ferenčak, Ivana
collection PubMed
description Background: Due to rapid spread, the Omicron variant has become the dominant SARS-CoV-2 variant responsible for infections worldwide. We present the first detection of the Omicron variant in Croatia which resulted in rapid cross-border spreading. Methods: Whole-genome sequencing was performed using the Illumina MiniSeq sequencing system. SARS-CoV-2 lineages were identified using the PANGOLIN and GISAID databases. Results: The first case of the Omicron variant (BA.1.17) emerged in Croatia after a workshop held in Zagreb in November 2021. The patient reported a history of previous COVID-19 and received two doses of an mRNA vaccine. Three additional cases were detected among Croatian participants of the workshop. At the beginning of December, SARS-CoV-2 infection was confirmed in one participant from Montenegro and her husband. Phylogenetic analysis showed that the detected Omicron variants were closely related to the first Croatian case, confirming the connection with the workshop outbreak and rapid cross-border spreading. Subsequent analyses of SARS-CoV-2 positive samples in Croatia showed the rapid introduction of the Omicron variant and depletion of the Delta variant resulting in the fifth pandemic wave. Conclusions: Genomic monitoring and early detection of novel SARS-CoV-2 variants are essential to implement timely epidemiological interventions and reduce further transmission in the population.
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spelling pubmed-91452082022-05-29 SARS-CoV-2 Omicron Variant in Croatia—Rapid Detection of the First Case and Cross-Border Spread Ferenčak, Ivana Obrovac, Mihaela Žmak, Ljiljana Kuzle, Josipa Petrović, Goranka Vilibić-Čavlek, Tatjana Jurić, Dragan Jurić, Anita Hruškar, Željka Capak, Krunoslav Stevanović, Vladimir Milanović, Maja Govedarica, Marija Vujošević, Danijela Tabain, Irena Pathogens Communication Background: Due to rapid spread, the Omicron variant has become the dominant SARS-CoV-2 variant responsible for infections worldwide. We present the first detection of the Omicron variant in Croatia which resulted in rapid cross-border spreading. Methods: Whole-genome sequencing was performed using the Illumina MiniSeq sequencing system. SARS-CoV-2 lineages were identified using the PANGOLIN and GISAID databases. Results: The first case of the Omicron variant (BA.1.17) emerged in Croatia after a workshop held in Zagreb in November 2021. The patient reported a history of previous COVID-19 and received two doses of an mRNA vaccine. Three additional cases were detected among Croatian participants of the workshop. At the beginning of December, SARS-CoV-2 infection was confirmed in one participant from Montenegro and her husband. Phylogenetic analysis showed that the detected Omicron variants were closely related to the first Croatian case, confirming the connection with the workshop outbreak and rapid cross-border spreading. Subsequent analyses of SARS-CoV-2 positive samples in Croatia showed the rapid introduction of the Omicron variant and depletion of the Delta variant resulting in the fifth pandemic wave. Conclusions: Genomic monitoring and early detection of novel SARS-CoV-2 variants are essential to implement timely epidemiological interventions and reduce further transmission in the population. MDPI 2022-04-26 /pmc/articles/PMC9145208/ /pubmed/35631032 http://dx.doi.org/10.3390/pathogens11050511 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Ferenčak, Ivana
Obrovac, Mihaela
Žmak, Ljiljana
Kuzle, Josipa
Petrović, Goranka
Vilibić-Čavlek, Tatjana
Jurić, Dragan
Jurić, Anita
Hruškar, Željka
Capak, Krunoslav
Stevanović, Vladimir
Milanović, Maja
Govedarica, Marija
Vujošević, Danijela
Tabain, Irena
SARS-CoV-2 Omicron Variant in Croatia—Rapid Detection of the First Case and Cross-Border Spread
title SARS-CoV-2 Omicron Variant in Croatia—Rapid Detection of the First Case and Cross-Border Spread
title_full SARS-CoV-2 Omicron Variant in Croatia—Rapid Detection of the First Case and Cross-Border Spread
title_fullStr SARS-CoV-2 Omicron Variant in Croatia—Rapid Detection of the First Case and Cross-Border Spread
title_full_unstemmed SARS-CoV-2 Omicron Variant in Croatia—Rapid Detection of the First Case and Cross-Border Spread
title_short SARS-CoV-2 Omicron Variant in Croatia—Rapid Detection of the First Case and Cross-Border Spread
title_sort sars-cov-2 omicron variant in croatia—rapid detection of the first case and cross-border spread
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145208/
https://www.ncbi.nlm.nih.gov/pubmed/35631032
http://dx.doi.org/10.3390/pathogens11050511
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