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Indirect SPECT Imaging Evaluation for Possible Nose-to-Brain Drug Delivery Using a Compound with Poor Blood–Brain Barrier Permeability in Mice

Single-photon emission computed tomography (SPECT) imaging using intravenous radioactive ligand administration to indirectly evaluate the time-dependent effect of intranasal drugs with poor blood-brain barrier permeability on brain drug distributions in mice was evaluated. The biodistribution was ex...

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Detalles Bibliográficos
Autores principales:	Mizutani, Asuka, Kobayashi, Masato, Ohuchi, Makoto, Sasaki, Keita, Muranaka, Yuka, Torikai, Yusuke, Fukakusa, Shota, Suzuki, Chie, Nishii, Ryuichi, Haruta, Shunji, Magata, Yasuhiro, Kawai, Keiichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145277/ https://www.ncbi.nlm.nih.gov/pubmed/35631611 http://dx.doi.org/10.3390/pharmaceutics14051026

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