Cargando…

Small Intestine Bacterial Overgrowth Can Form an Indigenous Proinflammatory Environment in the Duodenum: A Prospective Study

Small intestinal bacterial overgrowth (SIBO) contributes to the formation of an inflammatory environment in various intestinal and extraintestinal diseases. Cytokines that participate in these mechanisms are yet to be examined. Upper gastrointestinal endoscopy with duodenal aspiration was performed...

Descripción completa

Detalles Bibliográficos
Autores principales: Rizos, Evripidis, Pyleris, Emmanouel, Pimentel, Mark, Triantafyllou, Konstantinos, Giamarellos-Bourboulis, Evangelos J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145321/
https://www.ncbi.nlm.nih.gov/pubmed/35630404
http://dx.doi.org/10.3390/microorganisms10050960
_version_ 1784716258161197056
author Rizos, Evripidis
Pyleris, Emmanouel
Pimentel, Mark
Triantafyllou, Konstantinos
Giamarellos-Bourboulis, Evangelos J.
author_facet Rizos, Evripidis
Pyleris, Emmanouel
Pimentel, Mark
Triantafyllou, Konstantinos
Giamarellos-Bourboulis, Evangelos J.
author_sort Rizos, Evripidis
collection PubMed
description Small intestinal bacterial overgrowth (SIBO) contributes to the formation of an inflammatory environment in various intestinal and extraintestinal diseases. Cytokines that participate in these mechanisms are yet to be examined. Upper gastrointestinal endoscopy with duodenal aspiration was performed in 224 patients. Quantitative cultures of aerobic species were performed, concentrations of interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) were measured, and loads of Escherichia coli, Klebsiella pneumoniae, Methanobevibacter smithii, and Aeromonas spp. were detected via real-time PCR in the duodenal fluid. Analysis showed that the odds ratio (OR) for elevated IL-1β levels was 2.61 (1.06–6.43, p = 0.037) among patients with SIBO compared to patients without SIBO, while there was no significant difference at elevated IL-6 and TNF-α levels between patients with and without SIBO, using ≥10³ cfu/mL as a cut-off. The presence of all three elevated cytokine levels has OR 3.47 (1.06–11.34, p = 0.030) among patients with SIBO. Klebsiella pneumoniae detection was positively related with IL-6 and TNF-α levels, when Methanobevibacter smithii was positively related with IL-1β levels. The presence of SIBO is associated with elevated IL-1β levels in the duodenal fluid. There is a high prevalence of all three proinflammatory cytokine levels elevated (IL-1β, IL-6, and TNF-α) in the duodenal fluid among patients with SIBO.
format Online
Article
Text
id pubmed-9145321
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91453212022-05-29 Small Intestine Bacterial Overgrowth Can Form an Indigenous Proinflammatory Environment in the Duodenum: A Prospective Study Rizos, Evripidis Pyleris, Emmanouel Pimentel, Mark Triantafyllou, Konstantinos Giamarellos-Bourboulis, Evangelos J. Microorganisms Article Small intestinal bacterial overgrowth (SIBO) contributes to the formation of an inflammatory environment in various intestinal and extraintestinal diseases. Cytokines that participate in these mechanisms are yet to be examined. Upper gastrointestinal endoscopy with duodenal aspiration was performed in 224 patients. Quantitative cultures of aerobic species were performed, concentrations of interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) were measured, and loads of Escherichia coli, Klebsiella pneumoniae, Methanobevibacter smithii, and Aeromonas spp. were detected via real-time PCR in the duodenal fluid. Analysis showed that the odds ratio (OR) for elevated IL-1β levels was 2.61 (1.06–6.43, p = 0.037) among patients with SIBO compared to patients without SIBO, while there was no significant difference at elevated IL-6 and TNF-α levels between patients with and without SIBO, using ≥10³ cfu/mL as a cut-off. The presence of all three elevated cytokine levels has OR 3.47 (1.06–11.34, p = 0.030) among patients with SIBO. Klebsiella pneumoniae detection was positively related with IL-6 and TNF-α levels, when Methanobevibacter smithii was positively related with IL-1β levels. The presence of SIBO is associated with elevated IL-1β levels in the duodenal fluid. There is a high prevalence of all three proinflammatory cytokine levels elevated (IL-1β, IL-6, and TNF-α) in the duodenal fluid among patients with SIBO. MDPI 2022-05-02 /pmc/articles/PMC9145321/ /pubmed/35630404 http://dx.doi.org/10.3390/microorganisms10050960 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rizos, Evripidis
Pyleris, Emmanouel
Pimentel, Mark
Triantafyllou, Konstantinos
Giamarellos-Bourboulis, Evangelos J.
Small Intestine Bacterial Overgrowth Can Form an Indigenous Proinflammatory Environment in the Duodenum: A Prospective Study
title Small Intestine Bacterial Overgrowth Can Form an Indigenous Proinflammatory Environment in the Duodenum: A Prospective Study
title_full Small Intestine Bacterial Overgrowth Can Form an Indigenous Proinflammatory Environment in the Duodenum: A Prospective Study
title_fullStr Small Intestine Bacterial Overgrowth Can Form an Indigenous Proinflammatory Environment in the Duodenum: A Prospective Study
title_full_unstemmed Small Intestine Bacterial Overgrowth Can Form an Indigenous Proinflammatory Environment in the Duodenum: A Prospective Study
title_short Small Intestine Bacterial Overgrowth Can Form an Indigenous Proinflammatory Environment in the Duodenum: A Prospective Study
title_sort small intestine bacterial overgrowth can form an indigenous proinflammatory environment in the duodenum: a prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145321/
https://www.ncbi.nlm.nih.gov/pubmed/35630404
http://dx.doi.org/10.3390/microorganisms10050960
work_keys_str_mv AT rizosevripidis smallintestinebacterialovergrowthcanformanindigenousproinflammatoryenvironmentintheduodenumaprospectivestudy
AT pylerisemmanouel smallintestinebacterialovergrowthcanformanindigenousproinflammatoryenvironmentintheduodenumaprospectivestudy
AT pimentelmark smallintestinebacterialovergrowthcanformanindigenousproinflammatoryenvironmentintheduodenumaprospectivestudy
AT triantafylloukonstantinos smallintestinebacterialovergrowthcanformanindigenousproinflammatoryenvironmentintheduodenumaprospectivestudy
AT giamarellosbourboulisevangelosj smallintestinebacterialovergrowthcanformanindigenousproinflammatoryenvironmentintheduodenumaprospectivestudy