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miR-155 exerts posttranscriptional control of autoimmune regulator (Aire) and tissue-restricted antigen genes in medullary thymic epithelial cells

BACKGROUND: The autoimmune regulator (Aire) gene is critical for the appropriate establishment of central immune tolerance. As one of the main controllers of promiscuous gene expression in the thymus, Aire promotes the expression of thousands of downstream tissue-restricted antigen (TRA) genes, cell...

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Detalles Bibliográficos
Autores principales: Tanaka, Pedro Paranhos, Oliveira, Ernna Hérida, Vieira-Machado, Mayara Cristina, Duarte, Max Jordan, Assis, Amanda Freire, Bombonato-Prado, Karina Fittipaldi, Passos, Geraldo Aleixo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145475/
https://www.ncbi.nlm.nih.gov/pubmed/35643451
http://dx.doi.org/10.1186/s12864-022-08631-4

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