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Pancreatic Stone Protein as a Biomarker for Sepsis at the Emergency Department of a Large Tertiary Hospital

Early recognition of sepsis is essential for improving outcomes and preventing complications such as organ failure, depression, and neurocognitive impairment. The emergency department (ED) plays a key role in the early identification of sepsis, but clinicians lack diagnostic tools. Potentially, biom...

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Autores principales: de Hond, Titus A. P., Oosterheert, Jan Jelrik, van Hemert-Glaubitz, Susan J. M., Musson, Ruben E. A., Kaasjager, Karin A. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145478/
https://www.ncbi.nlm.nih.gov/pubmed/35631080
http://dx.doi.org/10.3390/pathogens11050559
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author de Hond, Titus A. P.
Oosterheert, Jan Jelrik
van Hemert-Glaubitz, Susan J. M.
Musson, Ruben E. A.
Kaasjager, Karin A. H.
author_facet de Hond, Titus A. P.
Oosterheert, Jan Jelrik
van Hemert-Glaubitz, Susan J. M.
Musson, Ruben E. A.
Kaasjager, Karin A. H.
author_sort de Hond, Titus A. P.
collection PubMed
description Early recognition of sepsis is essential for improving outcomes and preventing complications such as organ failure, depression, and neurocognitive impairment. The emergency department (ED) plays a key role in the early identification of sepsis, but clinicians lack diagnostic tools. Potentially, biomarkers could be helpful in assisting clinicians in the ED, but no marker has yet been successfully implemented in daily practice with good clinical performance. Pancreatic stone protein (PSP) is a promising biomarker in the context of sepsis, but little is known about the diagnostic performance of PSP in the ED. We prospectively investigated the diagnostic value of PSP in such a population for patients suspected of infection. PSP was compared with currently used biomarkers, including white blood cell count (WBC) and C-reactive protein (CRP). Of the 156 patients included in this study, 74 (47.4%) were diagnosed with uncomplicated infection and 26 (16.7%) patients with sepsis, while 56 (35.9%) eventually had no infection. PSP was significantly higher for sepsis patients compared to patients with no sepsis. In multivariate regression, PSP was a significant predictor for sepsis, with an area under the curve (AUC) of 0.69. Positive and negative predictive values for this model were 100% and 84.4%, respectively. Altogether, these findings show that PSP, measured at the ED of a tertiary hospital, is associated with sepsis but lacks the diagnostic performance to be used as single marker.
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spelling pubmed-91454782022-05-29 Pancreatic Stone Protein as a Biomarker for Sepsis at the Emergency Department of a Large Tertiary Hospital de Hond, Titus A. P. Oosterheert, Jan Jelrik van Hemert-Glaubitz, Susan J. M. Musson, Ruben E. A. Kaasjager, Karin A. H. Pathogens Article Early recognition of sepsis is essential for improving outcomes and preventing complications such as organ failure, depression, and neurocognitive impairment. The emergency department (ED) plays a key role in the early identification of sepsis, but clinicians lack diagnostic tools. Potentially, biomarkers could be helpful in assisting clinicians in the ED, but no marker has yet been successfully implemented in daily practice with good clinical performance. Pancreatic stone protein (PSP) is a promising biomarker in the context of sepsis, but little is known about the diagnostic performance of PSP in the ED. We prospectively investigated the diagnostic value of PSP in such a population for patients suspected of infection. PSP was compared with currently used biomarkers, including white blood cell count (WBC) and C-reactive protein (CRP). Of the 156 patients included in this study, 74 (47.4%) were diagnosed with uncomplicated infection and 26 (16.7%) patients with sepsis, while 56 (35.9%) eventually had no infection. PSP was significantly higher for sepsis patients compared to patients with no sepsis. In multivariate regression, PSP was a significant predictor for sepsis, with an area under the curve (AUC) of 0.69. Positive and negative predictive values for this model were 100% and 84.4%, respectively. Altogether, these findings show that PSP, measured at the ED of a tertiary hospital, is associated with sepsis but lacks the diagnostic performance to be used as single marker. MDPI 2022-05-09 /pmc/articles/PMC9145478/ /pubmed/35631080 http://dx.doi.org/10.3390/pathogens11050559 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Hond, Titus A. P.
Oosterheert, Jan Jelrik
van Hemert-Glaubitz, Susan J. M.
Musson, Ruben E. A.
Kaasjager, Karin A. H.
Pancreatic Stone Protein as a Biomarker for Sepsis at the Emergency Department of a Large Tertiary Hospital
title Pancreatic Stone Protein as a Biomarker for Sepsis at the Emergency Department of a Large Tertiary Hospital
title_full Pancreatic Stone Protein as a Biomarker for Sepsis at the Emergency Department of a Large Tertiary Hospital
title_fullStr Pancreatic Stone Protein as a Biomarker for Sepsis at the Emergency Department of a Large Tertiary Hospital
title_full_unstemmed Pancreatic Stone Protein as a Biomarker for Sepsis at the Emergency Department of a Large Tertiary Hospital
title_short Pancreatic Stone Protein as a Biomarker for Sepsis at the Emergency Department of a Large Tertiary Hospital
title_sort pancreatic stone protein as a biomarker for sepsis at the emergency department of a large tertiary hospital
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145478/
https://www.ncbi.nlm.nih.gov/pubmed/35631080
http://dx.doi.org/10.3390/pathogens11050559
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