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Photopharmacology of Antimitotic Agents
Antimitotic agents such as the clinically approved vinca alkaloids, taxanes and epothilone can arrest cell growth during interphase and are therefore among the most important drugs available for treating cancer. These agents suppress microtubule dynamics and thus interfere with intracellular transpo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145521/ https://www.ncbi.nlm.nih.gov/pubmed/35628467 http://dx.doi.org/10.3390/ijms23105657 |
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author | Kirchner, Susanne Pianowski, Zbigniew |
author_facet | Kirchner, Susanne Pianowski, Zbigniew |
author_sort | Kirchner, Susanne |
collection | PubMed |
description | Antimitotic agents such as the clinically approved vinca alkaloids, taxanes and epothilone can arrest cell growth during interphase and are therefore among the most important drugs available for treating cancer. These agents suppress microtubule dynamics and thus interfere with intracellular transport, inhibit cell proliferation and promote cell death. Because these drugs target biological processes that are essential to all cells, they face an additional challenge when compared to most other drug classes. General toxicity can limit the applicable dose and therefore reduce therapeutic benefits. Photopharmacology aims to avoid these side-effects by introducing compounds that can be applied globally to cells in their inactive form, then be selectively induced to bioactivity in targeted cells or tissue during a defined time window. This review discusses photoswitchable analogues of antimitotic agents that have been developed by combining different photoswitchable motifs with microtubule-stabilizing or microtubule-destabilizing agents. |
format | Online Article Text |
id | pubmed-9145521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91455212022-05-29 Photopharmacology of Antimitotic Agents Kirchner, Susanne Pianowski, Zbigniew Int J Mol Sci Review Antimitotic agents such as the clinically approved vinca alkaloids, taxanes and epothilone can arrest cell growth during interphase and are therefore among the most important drugs available for treating cancer. These agents suppress microtubule dynamics and thus interfere with intracellular transport, inhibit cell proliferation and promote cell death. Because these drugs target biological processes that are essential to all cells, they face an additional challenge when compared to most other drug classes. General toxicity can limit the applicable dose and therefore reduce therapeutic benefits. Photopharmacology aims to avoid these side-effects by introducing compounds that can be applied globally to cells in their inactive form, then be selectively induced to bioactivity in targeted cells or tissue during a defined time window. This review discusses photoswitchable analogues of antimitotic agents that have been developed by combining different photoswitchable motifs with microtubule-stabilizing or microtubule-destabilizing agents. MDPI 2022-05-18 /pmc/articles/PMC9145521/ /pubmed/35628467 http://dx.doi.org/10.3390/ijms23105657 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kirchner, Susanne Pianowski, Zbigniew Photopharmacology of Antimitotic Agents |
title | Photopharmacology of Antimitotic Agents |
title_full | Photopharmacology of Antimitotic Agents |
title_fullStr | Photopharmacology of Antimitotic Agents |
title_full_unstemmed | Photopharmacology of Antimitotic Agents |
title_short | Photopharmacology of Antimitotic Agents |
title_sort | photopharmacology of antimitotic agents |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145521/ https://www.ncbi.nlm.nih.gov/pubmed/35628467 http://dx.doi.org/10.3390/ijms23105657 |
work_keys_str_mv | AT kirchnersusanne photopharmacologyofantimitoticagents AT pianowskizbigniew photopharmacologyofantimitoticagents |