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Photopharmacology of Antimitotic Agents

Antimitotic agents such as the clinically approved vinca alkaloids, taxanes and epothilone can arrest cell growth during interphase and are therefore among the most important drugs available for treating cancer. These agents suppress microtubule dynamics and thus interfere with intracellular transpo...

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Detalles Bibliográficos
Autores principales: Kirchner, Susanne, Pianowski, Zbigniew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145521/
https://www.ncbi.nlm.nih.gov/pubmed/35628467
http://dx.doi.org/10.3390/ijms23105657
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author Kirchner, Susanne
Pianowski, Zbigniew
author_facet Kirchner, Susanne
Pianowski, Zbigniew
author_sort Kirchner, Susanne
collection PubMed
description Antimitotic agents such as the clinically approved vinca alkaloids, taxanes and epothilone can arrest cell growth during interphase and are therefore among the most important drugs available for treating cancer. These agents suppress microtubule dynamics and thus interfere with intracellular transport, inhibit cell proliferation and promote cell death. Because these drugs target biological processes that are essential to all cells, they face an additional challenge when compared to most other drug classes. General toxicity can limit the applicable dose and therefore reduce therapeutic benefits. Photopharmacology aims to avoid these side-effects by introducing compounds that can be applied globally to cells in their inactive form, then be selectively induced to bioactivity in targeted cells or tissue during a defined time window. This review discusses photoswitchable analogues of antimitotic agents that have been developed by combining different photoswitchable motifs with microtubule-stabilizing or microtubule-destabilizing agents.
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spelling pubmed-91455212022-05-29 Photopharmacology of Antimitotic Agents Kirchner, Susanne Pianowski, Zbigniew Int J Mol Sci Review Antimitotic agents such as the clinically approved vinca alkaloids, taxanes and epothilone can arrest cell growth during interphase and are therefore among the most important drugs available for treating cancer. These agents suppress microtubule dynamics and thus interfere with intracellular transport, inhibit cell proliferation and promote cell death. Because these drugs target biological processes that are essential to all cells, they face an additional challenge when compared to most other drug classes. General toxicity can limit the applicable dose and therefore reduce therapeutic benefits. Photopharmacology aims to avoid these side-effects by introducing compounds that can be applied globally to cells in their inactive form, then be selectively induced to bioactivity in targeted cells or tissue during a defined time window. This review discusses photoswitchable analogues of antimitotic agents that have been developed by combining different photoswitchable motifs with microtubule-stabilizing or microtubule-destabilizing agents. MDPI 2022-05-18 /pmc/articles/PMC9145521/ /pubmed/35628467 http://dx.doi.org/10.3390/ijms23105657 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kirchner, Susanne
Pianowski, Zbigniew
Photopharmacology of Antimitotic Agents
title Photopharmacology of Antimitotic Agents
title_full Photopharmacology of Antimitotic Agents
title_fullStr Photopharmacology of Antimitotic Agents
title_full_unstemmed Photopharmacology of Antimitotic Agents
title_short Photopharmacology of Antimitotic Agents
title_sort photopharmacology of antimitotic agents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145521/
https://www.ncbi.nlm.nih.gov/pubmed/35628467
http://dx.doi.org/10.3390/ijms23105657
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