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Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner

The duodenal-jejunal bypass liner (Endobarrier) is an endoscopic treatment for obesity and type 2 diabetes mellitus (T2DM). It creates exclusion of the proximal small intestine similar to that after Roux-en-Y Gastric Bypass (RYGB) surgery. The objective of this study was to employ a reductionist app...

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Autores principales: Aldhwayan, Madhawi M., Al-Najim, Werd, Ruban, Aruchuna, Glaysher, Michael Alan, Johnson, Brett, Chhina, Navpreet, Dimitriadis, Georgios K., Prechtl, Christina Gabriele, Johnson, Nicholas A., Byrne, James Patrick, Goldstone, Anthony Peter, Teare, Julian P., Le Roux, Carel W., Miras, Alexander Dimitri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145649/
https://www.ncbi.nlm.nih.gov/pubmed/35631283
http://dx.doi.org/10.3390/nu14102141
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author Aldhwayan, Madhawi M.
Al-Najim, Werd
Ruban, Aruchuna
Glaysher, Michael Alan
Johnson, Brett
Chhina, Navpreet
Dimitriadis, Georgios K.
Prechtl, Christina Gabriele
Johnson, Nicholas A.
Byrne, James Patrick
Goldstone, Anthony Peter
Teare, Julian P.
Le Roux, Carel W.
Miras, Alexander Dimitri
author_facet Aldhwayan, Madhawi M.
Al-Najim, Werd
Ruban, Aruchuna
Glaysher, Michael Alan
Johnson, Brett
Chhina, Navpreet
Dimitriadis, Georgios K.
Prechtl, Christina Gabriele
Johnson, Nicholas A.
Byrne, James Patrick
Goldstone, Anthony Peter
Teare, Julian P.
Le Roux, Carel W.
Miras, Alexander Dimitri
author_sort Aldhwayan, Madhawi M.
collection PubMed
description The duodenal-jejunal bypass liner (Endobarrier) is an endoscopic treatment for obesity and type 2 diabetes mellitus (T2DM). It creates exclusion of the proximal small intestine similar to that after Roux-en-Y Gastric Bypass (RYGB) surgery. The objective of this study was to employ a reductionist approach to determine whether bypass of the proximal intestine is the component conferring the effects of RYGB on food intake and sweet taste preference using the Endobarrier as a research tool. A nested mechanistic study within a large randomised controlled trial compared the impact of lifestyle modification with vs. without Endobarrier insertion in patients with obesity and T2DM. Forty-seven participants were randomised and assessed at several timepoints using direct and indirect assessments of food intake, food preference and taste function. Patients within the Endobarrier group lost numerically more weight compared to the control group. Using food diaries, our results demonstrated similar reductions of food intake in both groups. There were no significant differences in food preference and sensory, appetitive reward, or consummatory reward domain of sweet taste function between groups or changes within groups. In conclusion, the superior weight loss seen in patients with obesity and T2DM who underwent the Endobarrier insertion was not due to a reduction in energy intake or change in food preferences.
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spelling pubmed-91456492022-05-29 Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner Aldhwayan, Madhawi M. Al-Najim, Werd Ruban, Aruchuna Glaysher, Michael Alan Johnson, Brett Chhina, Navpreet Dimitriadis, Georgios K. Prechtl, Christina Gabriele Johnson, Nicholas A. Byrne, James Patrick Goldstone, Anthony Peter Teare, Julian P. Le Roux, Carel W. Miras, Alexander Dimitri Nutrients Article The duodenal-jejunal bypass liner (Endobarrier) is an endoscopic treatment for obesity and type 2 diabetes mellitus (T2DM). It creates exclusion of the proximal small intestine similar to that after Roux-en-Y Gastric Bypass (RYGB) surgery. The objective of this study was to employ a reductionist approach to determine whether bypass of the proximal intestine is the component conferring the effects of RYGB on food intake and sweet taste preference using the Endobarrier as a research tool. A nested mechanistic study within a large randomised controlled trial compared the impact of lifestyle modification with vs. without Endobarrier insertion in patients with obesity and T2DM. Forty-seven participants were randomised and assessed at several timepoints using direct and indirect assessments of food intake, food preference and taste function. Patients within the Endobarrier group lost numerically more weight compared to the control group. Using food diaries, our results demonstrated similar reductions of food intake in both groups. There were no significant differences in food preference and sensory, appetitive reward, or consummatory reward domain of sweet taste function between groups or changes within groups. In conclusion, the superior weight loss seen in patients with obesity and T2DM who underwent the Endobarrier insertion was not due to a reduction in energy intake or change in food preferences. MDPI 2022-05-20 /pmc/articles/PMC9145649/ /pubmed/35631283 http://dx.doi.org/10.3390/nu14102141 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aldhwayan, Madhawi M.
Al-Najim, Werd
Ruban, Aruchuna
Glaysher, Michael Alan
Johnson, Brett
Chhina, Navpreet
Dimitriadis, Georgios K.
Prechtl, Christina Gabriele
Johnson, Nicholas A.
Byrne, James Patrick
Goldstone, Anthony Peter
Teare, Julian P.
Le Roux, Carel W.
Miras, Alexander Dimitri
Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner
title Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner
title_full Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner
title_fullStr Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner
title_full_unstemmed Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner
title_short Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner
title_sort does bypass of the proximal small intestine impact food intake, preference, and taste function in humans? an experimental medicine study using the duodenal-jejunal bypass liner
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145649/
https://www.ncbi.nlm.nih.gov/pubmed/35631283
http://dx.doi.org/10.3390/nu14102141
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