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Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner
The duodenal-jejunal bypass liner (Endobarrier) is an endoscopic treatment for obesity and type 2 diabetes mellitus (T2DM). It creates exclusion of the proximal small intestine similar to that after Roux-en-Y Gastric Bypass (RYGB) surgery. The objective of this study was to employ a reductionist app...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145649/ https://www.ncbi.nlm.nih.gov/pubmed/35631283 http://dx.doi.org/10.3390/nu14102141 |
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author | Aldhwayan, Madhawi M. Al-Najim, Werd Ruban, Aruchuna Glaysher, Michael Alan Johnson, Brett Chhina, Navpreet Dimitriadis, Georgios K. Prechtl, Christina Gabriele Johnson, Nicholas A. Byrne, James Patrick Goldstone, Anthony Peter Teare, Julian P. Le Roux, Carel W. Miras, Alexander Dimitri |
author_facet | Aldhwayan, Madhawi M. Al-Najim, Werd Ruban, Aruchuna Glaysher, Michael Alan Johnson, Brett Chhina, Navpreet Dimitriadis, Georgios K. Prechtl, Christina Gabriele Johnson, Nicholas A. Byrne, James Patrick Goldstone, Anthony Peter Teare, Julian P. Le Roux, Carel W. Miras, Alexander Dimitri |
author_sort | Aldhwayan, Madhawi M. |
collection | PubMed |
description | The duodenal-jejunal bypass liner (Endobarrier) is an endoscopic treatment for obesity and type 2 diabetes mellitus (T2DM). It creates exclusion of the proximal small intestine similar to that after Roux-en-Y Gastric Bypass (RYGB) surgery. The objective of this study was to employ a reductionist approach to determine whether bypass of the proximal intestine is the component conferring the effects of RYGB on food intake and sweet taste preference using the Endobarrier as a research tool. A nested mechanistic study within a large randomised controlled trial compared the impact of lifestyle modification with vs. without Endobarrier insertion in patients with obesity and T2DM. Forty-seven participants were randomised and assessed at several timepoints using direct and indirect assessments of food intake, food preference and taste function. Patients within the Endobarrier group lost numerically more weight compared to the control group. Using food diaries, our results demonstrated similar reductions of food intake in both groups. There were no significant differences in food preference and sensory, appetitive reward, or consummatory reward domain of sweet taste function between groups or changes within groups. In conclusion, the superior weight loss seen in patients with obesity and T2DM who underwent the Endobarrier insertion was not due to a reduction in energy intake or change in food preferences. |
format | Online Article Text |
id | pubmed-9145649 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91456492022-05-29 Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner Aldhwayan, Madhawi M. Al-Najim, Werd Ruban, Aruchuna Glaysher, Michael Alan Johnson, Brett Chhina, Navpreet Dimitriadis, Georgios K. Prechtl, Christina Gabriele Johnson, Nicholas A. Byrne, James Patrick Goldstone, Anthony Peter Teare, Julian P. Le Roux, Carel W. Miras, Alexander Dimitri Nutrients Article The duodenal-jejunal bypass liner (Endobarrier) is an endoscopic treatment for obesity and type 2 diabetes mellitus (T2DM). It creates exclusion of the proximal small intestine similar to that after Roux-en-Y Gastric Bypass (RYGB) surgery. The objective of this study was to employ a reductionist approach to determine whether bypass of the proximal intestine is the component conferring the effects of RYGB on food intake and sweet taste preference using the Endobarrier as a research tool. A nested mechanistic study within a large randomised controlled trial compared the impact of lifestyle modification with vs. without Endobarrier insertion in patients with obesity and T2DM. Forty-seven participants were randomised and assessed at several timepoints using direct and indirect assessments of food intake, food preference and taste function. Patients within the Endobarrier group lost numerically more weight compared to the control group. Using food diaries, our results demonstrated similar reductions of food intake in both groups. There were no significant differences in food preference and sensory, appetitive reward, or consummatory reward domain of sweet taste function between groups or changes within groups. In conclusion, the superior weight loss seen in patients with obesity and T2DM who underwent the Endobarrier insertion was not due to a reduction in energy intake or change in food preferences. MDPI 2022-05-20 /pmc/articles/PMC9145649/ /pubmed/35631283 http://dx.doi.org/10.3390/nu14102141 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Aldhwayan, Madhawi M. Al-Najim, Werd Ruban, Aruchuna Glaysher, Michael Alan Johnson, Brett Chhina, Navpreet Dimitriadis, Georgios K. Prechtl, Christina Gabriele Johnson, Nicholas A. Byrne, James Patrick Goldstone, Anthony Peter Teare, Julian P. Le Roux, Carel W. Miras, Alexander Dimitri Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner |
title | Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner |
title_full | Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner |
title_fullStr | Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner |
title_full_unstemmed | Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner |
title_short | Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner |
title_sort | does bypass of the proximal small intestine impact food intake, preference, and taste function in humans? an experimental medicine study using the duodenal-jejunal bypass liner |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145649/ https://www.ncbi.nlm.nih.gov/pubmed/35631283 http://dx.doi.org/10.3390/nu14102141 |
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