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The Relationship between Angiogenic Factors and Energy Metabolism in Preeclampsia
Antiangiogenic factors are currently used for the prediction of preeclampsia. The present study aimed to evaluate the relationship between antiangiogenic factors and lipid and carbohydrate metabolism in maternal plasma and placenta. We analyzed 56 pregnant women, 30 healthy and 26 with preeclampsia...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145768/ https://www.ncbi.nlm.nih.gov/pubmed/35631313 http://dx.doi.org/10.3390/nu14102172 |
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author | Abascal-Saiz, Alejandra Duque-Alcorta, Marta Fioravantti, Victoria Antolín, Eugenia Fuente-Luelmo, Eva Haro, María Ramos-Álvarez, María P. Perdomo, Germán Bartha, José L. |
author_facet | Abascal-Saiz, Alejandra Duque-Alcorta, Marta Fioravantti, Victoria Antolín, Eugenia Fuente-Luelmo, Eva Haro, María Ramos-Álvarez, María P. Perdomo, Germán Bartha, José L. |
author_sort | Abascal-Saiz, Alejandra |
collection | PubMed |
description | Antiangiogenic factors are currently used for the prediction of preeclampsia. The present study aimed to evaluate the relationship between antiangiogenic factors and lipid and carbohydrate metabolism in maternal plasma and placenta. We analyzed 56 pregnant women, 30 healthy and 26 with preeclampsia (including early and late onset). We compared antiangiogenic factors soluble Fms-like Tyrosine Kinase-1 (sfLt-1), placental growth factor (PlGF), and soluble endoglin (sEng)), lipid and carbohydrate metabolism in maternal plasma, and lipid metabolism in the placenta from assays of fatty acid oxidation, fatty acid esterification, and triglyceride levels in all groups. Antiangiogenic factors sFlt-1, sFlt-1/PlGF ratio, and sEng showed a positive correlation with triglyceride, free fatty acid, and C-peptide maternal serum levels. However, there was no relationship between angiogenic factors and placental lipid metabolism parameters. Free fatty acids were predictive of elevated sFlt-1 and sEng, while C-peptide was predictive of an elevated sFlt1/PlGF ratio. The findings in this study generate a model to predict elevated antiangiogenic factor values and the relationship between them with different products of lipid and carbohydrate metabolism in maternal serum and placenta in preeclampsia. |
format | Online Article Text |
id | pubmed-9145768 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91457682022-05-29 The Relationship between Angiogenic Factors and Energy Metabolism in Preeclampsia Abascal-Saiz, Alejandra Duque-Alcorta, Marta Fioravantti, Victoria Antolín, Eugenia Fuente-Luelmo, Eva Haro, María Ramos-Álvarez, María P. Perdomo, Germán Bartha, José L. Nutrients Article Antiangiogenic factors are currently used for the prediction of preeclampsia. The present study aimed to evaluate the relationship between antiangiogenic factors and lipid and carbohydrate metabolism in maternal plasma and placenta. We analyzed 56 pregnant women, 30 healthy and 26 with preeclampsia (including early and late onset). We compared antiangiogenic factors soluble Fms-like Tyrosine Kinase-1 (sfLt-1), placental growth factor (PlGF), and soluble endoglin (sEng)), lipid and carbohydrate metabolism in maternal plasma, and lipid metabolism in the placenta from assays of fatty acid oxidation, fatty acid esterification, and triglyceride levels in all groups. Antiangiogenic factors sFlt-1, sFlt-1/PlGF ratio, and sEng showed a positive correlation with triglyceride, free fatty acid, and C-peptide maternal serum levels. However, there was no relationship between angiogenic factors and placental lipid metabolism parameters. Free fatty acids were predictive of elevated sFlt-1 and sEng, while C-peptide was predictive of an elevated sFlt1/PlGF ratio. The findings in this study generate a model to predict elevated antiangiogenic factor values and the relationship between them with different products of lipid and carbohydrate metabolism in maternal serum and placenta in preeclampsia. MDPI 2022-05-23 /pmc/articles/PMC9145768/ /pubmed/35631313 http://dx.doi.org/10.3390/nu14102172 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Abascal-Saiz, Alejandra Duque-Alcorta, Marta Fioravantti, Victoria Antolín, Eugenia Fuente-Luelmo, Eva Haro, María Ramos-Álvarez, María P. Perdomo, Germán Bartha, José L. The Relationship between Angiogenic Factors and Energy Metabolism in Preeclampsia |
title | The Relationship between Angiogenic Factors and Energy Metabolism in Preeclampsia |
title_full | The Relationship between Angiogenic Factors and Energy Metabolism in Preeclampsia |
title_fullStr | The Relationship between Angiogenic Factors and Energy Metabolism in Preeclampsia |
title_full_unstemmed | The Relationship between Angiogenic Factors and Energy Metabolism in Preeclampsia |
title_short | The Relationship between Angiogenic Factors and Energy Metabolism in Preeclampsia |
title_sort | relationship between angiogenic factors and energy metabolism in preeclampsia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145768/ https://www.ncbi.nlm.nih.gov/pubmed/35631313 http://dx.doi.org/10.3390/nu14102172 |
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