Cargando…

Clonal Tracing of Heart Regeneration

Cardiomyocytes in the adult mammalian heart have a low turnover during homeostasis. After myocardial injury, there is irreversible loss of cardiomyocytes, which results in subsequent scar formation and cardiac remodeling. In order to better understand and characterize the proliferative capacity of c...

Descripción completa

Detalles Bibliográficos
Autores principales: Kolluri, Kamal, Nazarian, Taline, Ardehali, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145832/
https://www.ncbi.nlm.nih.gov/pubmed/35621852
http://dx.doi.org/10.3390/jcdd9050141
_version_ 1784716412217982976
author Kolluri, Kamal
Nazarian, Taline
Ardehali, Reza
author_facet Kolluri, Kamal
Nazarian, Taline
Ardehali, Reza
author_sort Kolluri, Kamal
collection PubMed
description Cardiomyocytes in the adult mammalian heart have a low turnover during homeostasis. After myocardial injury, there is irreversible loss of cardiomyocytes, which results in subsequent scar formation and cardiac remodeling. In order to better understand and characterize the proliferative capacity of cardiomyocytes, in vivo methods have been developed to track their fate during normal development and after injury. Lineage tracing models are of particular interest due to their ability to record cell proliferation events over a long period of time, either during development or in response to a pathological event. This paper reviews two well-studied lineage-tracing, transgenic mouse models—mosaic analysis with double markers and rainbow reporter system.
format Online
Article
Text
id pubmed-9145832
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91458322022-05-29 Clonal Tracing of Heart Regeneration Kolluri, Kamal Nazarian, Taline Ardehali, Reza J Cardiovasc Dev Dis Review Cardiomyocytes in the adult mammalian heart have a low turnover during homeostasis. After myocardial injury, there is irreversible loss of cardiomyocytes, which results in subsequent scar formation and cardiac remodeling. In order to better understand and characterize the proliferative capacity of cardiomyocytes, in vivo methods have been developed to track their fate during normal development and after injury. Lineage tracing models are of particular interest due to their ability to record cell proliferation events over a long period of time, either during development or in response to a pathological event. This paper reviews two well-studied lineage-tracing, transgenic mouse models—mosaic analysis with double markers and rainbow reporter system. MDPI 2022-05-01 /pmc/articles/PMC9145832/ /pubmed/35621852 http://dx.doi.org/10.3390/jcdd9050141 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kolluri, Kamal
Nazarian, Taline
Ardehali, Reza
Clonal Tracing of Heart Regeneration
title Clonal Tracing of Heart Regeneration
title_full Clonal Tracing of Heart Regeneration
title_fullStr Clonal Tracing of Heart Regeneration
title_full_unstemmed Clonal Tracing of Heart Regeneration
title_short Clonal Tracing of Heart Regeneration
title_sort clonal tracing of heart regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145832/
https://www.ncbi.nlm.nih.gov/pubmed/35621852
http://dx.doi.org/10.3390/jcdd9050141
work_keys_str_mv AT kollurikamal clonaltracingofheartregeneration
AT nazariantaline clonaltracingofheartregeneration
AT ardehalireza clonaltracingofheartregeneration