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Clonal Tracing of Heart Regeneration
Cardiomyocytes in the adult mammalian heart have a low turnover during homeostasis. After myocardial injury, there is irreversible loss of cardiomyocytes, which results in subsequent scar formation and cardiac remodeling. In order to better understand and characterize the proliferative capacity of c...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145832/ https://www.ncbi.nlm.nih.gov/pubmed/35621852 http://dx.doi.org/10.3390/jcdd9050141 |
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author | Kolluri, Kamal Nazarian, Taline Ardehali, Reza |
author_facet | Kolluri, Kamal Nazarian, Taline Ardehali, Reza |
author_sort | Kolluri, Kamal |
collection | PubMed |
description | Cardiomyocytes in the adult mammalian heart have a low turnover during homeostasis. After myocardial injury, there is irreversible loss of cardiomyocytes, which results in subsequent scar formation and cardiac remodeling. In order to better understand and characterize the proliferative capacity of cardiomyocytes, in vivo methods have been developed to track their fate during normal development and after injury. Lineage tracing models are of particular interest due to their ability to record cell proliferation events over a long period of time, either during development or in response to a pathological event. This paper reviews two well-studied lineage-tracing, transgenic mouse models—mosaic analysis with double markers and rainbow reporter system. |
format | Online Article Text |
id | pubmed-9145832 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91458322022-05-29 Clonal Tracing of Heart Regeneration Kolluri, Kamal Nazarian, Taline Ardehali, Reza J Cardiovasc Dev Dis Review Cardiomyocytes in the adult mammalian heart have a low turnover during homeostasis. After myocardial injury, there is irreversible loss of cardiomyocytes, which results in subsequent scar formation and cardiac remodeling. In order to better understand and characterize the proliferative capacity of cardiomyocytes, in vivo methods have been developed to track their fate during normal development and after injury. Lineage tracing models are of particular interest due to their ability to record cell proliferation events over a long period of time, either during development or in response to a pathological event. This paper reviews two well-studied lineage-tracing, transgenic mouse models—mosaic analysis with double markers and rainbow reporter system. MDPI 2022-05-01 /pmc/articles/PMC9145832/ /pubmed/35621852 http://dx.doi.org/10.3390/jcdd9050141 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kolluri, Kamal Nazarian, Taline Ardehali, Reza Clonal Tracing of Heart Regeneration |
title | Clonal Tracing of Heart Regeneration |
title_full | Clonal Tracing of Heart Regeneration |
title_fullStr | Clonal Tracing of Heart Regeneration |
title_full_unstemmed | Clonal Tracing of Heart Regeneration |
title_short | Clonal Tracing of Heart Regeneration |
title_sort | clonal tracing of heart regeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145832/ https://www.ncbi.nlm.nih.gov/pubmed/35621852 http://dx.doi.org/10.3390/jcdd9050141 |
work_keys_str_mv | AT kollurikamal clonaltracingofheartregeneration AT nazariantaline clonaltracingofheartregeneration AT ardehalireza clonaltracingofheartregeneration |