SK119, a Novel Shikonin Derivative, Leads to Apoptosis in Melanoma Cell Lines and Exhibits Synergistic Effects with Vemurafenib and Cobimetinib

Melanoma is a complex and heterogenous disease, displays the deadliest form of skin cancer, and accounts for approx. 80% of all skin cancer deaths. In this study, we reported on the synthesis and pharmacological effects of a novel shikonin derivative (SK119), which is active in a nano-molar range an...

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Detalles Bibliográficos
Autores principales: Kretschmer, Nadine, Durchschein, Christin, Hufner, Antje, Rinner, Beate, Lohberger, Birgit, Bauer, Rudolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145845/
https://www.ncbi.nlm.nih.gov/pubmed/35628494
http://dx.doi.org/10.3390/ijms23105684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145845/
https://www.ncbi.nlm.nih.gov/pubmed/35628494
http://dx.doi.org/10.3390/ijms23105684

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