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A Systematic Review on Cannabinoids for Neuropathic Pain Administered by Routes Other than Oral or Inhalation

The use of cannabis and cannabinoid products for the treatment of neuropathic pain is a growing area of research. This type of pain has a high prevalence, limited response to available therapies and high social and economic costs. Systemic cannabinoid-based therapies have shown some unwanted side ef...

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Autores principales: Quintero, Jose-Manuel, Pulido, German, Giraldo, Luis-Fernando, Leon, Marta-Ximena, Diaz, Luis-Eduardo, Bustos, Rosa-Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145866/
https://www.ncbi.nlm.nih.gov/pubmed/35631782
http://dx.doi.org/10.3390/plants11101357
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author Quintero, Jose-Manuel
Pulido, German
Giraldo, Luis-Fernando
Leon, Marta-Ximena
Diaz, Luis-Eduardo
Bustos, Rosa-Helena
author_facet Quintero, Jose-Manuel
Pulido, German
Giraldo, Luis-Fernando
Leon, Marta-Ximena
Diaz, Luis-Eduardo
Bustos, Rosa-Helena
author_sort Quintero, Jose-Manuel
collection PubMed
description The use of cannabis and cannabinoid products for the treatment of neuropathic pain is a growing area of research. This type of pain has a high prevalence, limited response to available therapies and high social and economic costs. Systemic cannabinoid-based therapies have shown some unwanted side effects. Alternative routes of administration in the treatment of neuropathic pain may provide better acceptance for the treatment of multiple pathologies associated with neuropathic pain. To examine the efficacy, tolerability, and safety of cannabinoids (individualized formulations, phytocannabinoids, and synthetics) administered by routes other than oral or inhalation compared to placebo and/or conventional medications in the management of neuropathic pain. This systematic review of the literature reveals a lack of clinical research investigating cannabis by routes other than oral and inhalation as a potential treatment for neuropathic pain and highlights the need for further investigation with well-designed clinical trials. There is a significant lack of evidence indicating that cannabinoids administered by routes other than oral or inhaled may be an effective alternative, with better tolerance and safety in the treatment of neuropathic pain. Higher quality, long-term, randomized controlled trials are needed to examine whether cannabinoids administered by routes other than inhalation and oral routes may have a role in the treatment of neuropathic pain.
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spelling pubmed-91458662022-05-29 A Systematic Review on Cannabinoids for Neuropathic Pain Administered by Routes Other than Oral or Inhalation Quintero, Jose-Manuel Pulido, German Giraldo, Luis-Fernando Leon, Marta-Ximena Diaz, Luis-Eduardo Bustos, Rosa-Helena Plants (Basel) Systematic Review The use of cannabis and cannabinoid products for the treatment of neuropathic pain is a growing area of research. This type of pain has a high prevalence, limited response to available therapies and high social and economic costs. Systemic cannabinoid-based therapies have shown some unwanted side effects. Alternative routes of administration in the treatment of neuropathic pain may provide better acceptance for the treatment of multiple pathologies associated with neuropathic pain. To examine the efficacy, tolerability, and safety of cannabinoids (individualized formulations, phytocannabinoids, and synthetics) administered by routes other than oral or inhalation compared to placebo and/or conventional medications in the management of neuropathic pain. This systematic review of the literature reveals a lack of clinical research investigating cannabis by routes other than oral and inhalation as a potential treatment for neuropathic pain and highlights the need for further investigation with well-designed clinical trials. There is a significant lack of evidence indicating that cannabinoids administered by routes other than oral or inhaled may be an effective alternative, with better tolerance and safety in the treatment of neuropathic pain. Higher quality, long-term, randomized controlled trials are needed to examine whether cannabinoids administered by routes other than inhalation and oral routes may have a role in the treatment of neuropathic pain. MDPI 2022-05-20 /pmc/articles/PMC9145866/ /pubmed/35631782 http://dx.doi.org/10.3390/plants11101357 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Quintero, Jose-Manuel
Pulido, German
Giraldo, Luis-Fernando
Leon, Marta-Ximena
Diaz, Luis-Eduardo
Bustos, Rosa-Helena
A Systematic Review on Cannabinoids for Neuropathic Pain Administered by Routes Other than Oral or Inhalation
title A Systematic Review on Cannabinoids for Neuropathic Pain Administered by Routes Other than Oral or Inhalation
title_full A Systematic Review on Cannabinoids for Neuropathic Pain Administered by Routes Other than Oral or Inhalation
title_fullStr A Systematic Review on Cannabinoids for Neuropathic Pain Administered by Routes Other than Oral or Inhalation
title_full_unstemmed A Systematic Review on Cannabinoids for Neuropathic Pain Administered by Routes Other than Oral or Inhalation
title_short A Systematic Review on Cannabinoids for Neuropathic Pain Administered by Routes Other than Oral or Inhalation
title_sort systematic review on cannabinoids for neuropathic pain administered by routes other than oral or inhalation
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145866/
https://www.ncbi.nlm.nih.gov/pubmed/35631782
http://dx.doi.org/10.3390/plants11101357
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