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Potential Chemotherapeutic Effect of Selenium for Improved Canceration of Esophageal Cancer

Esophageal squamous cell carcinoma is the most common type of esophageal cancer and accounts for 5% of malignant tumor deaths. Recent research suggests that chronic inflammation and DNA damage may drive the onset of esophageal squamous cell carcinoma, implying that lowering chronic inflammation and...

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Autores principales: Ahsan, Anil, Liu, Zhiwei, Su, Ruibing, Liu, Chencai, Liao, Xiaoqi, Su, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145868/
https://www.ncbi.nlm.nih.gov/pubmed/35628320
http://dx.doi.org/10.3390/ijms23105509
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author Ahsan, Anil
Liu, Zhiwei
Su, Ruibing
Liu, Chencai
Liao, Xiaoqi
Su, Min
author_facet Ahsan, Anil
Liu, Zhiwei
Su, Ruibing
Liu, Chencai
Liao, Xiaoqi
Su, Min
author_sort Ahsan, Anil
collection PubMed
description Esophageal squamous cell carcinoma is the most common type of esophageal cancer and accounts for 5% of malignant tumor deaths. Recent research suggests that chronic inflammation and DNA damage may drive the onset of esophageal squamous cell carcinoma, implying that lowering chronic inflammation and DNA damage compounds may provide chemo-prevention. According to epidemiological and experimental evidence, selenium is linked to a lower risk of several malignancies, including esophageal squamous cell carcinoma. However, its exact mechanism is still unclear. In the present study, we used cell lines and a 4-NQO mice model to explore the anti-cancer mechanism of four types of selenium. Our findings indicated that selenium inhibited the proliferation, colony formation, and ROS level of ESCC cell lines in a time-dependent manner. Intriguingly, selenium treatment impeded 4-NQO-induced high-grade intraepithelial neoplasia and reduced the number of positive inflammatory cells by preserving DNA from oxidative damage. In addition, selenium significantly decreased the expression of Ki-67 and induced apoptosis. This study demonstrates that selenium has a significant chemo-preventive effect on ESCC by reducing high-grade dysplasia to low-grade dysplasia. For the first time, selenium was shown to slow down the progression of esophageal cancer by lowering inflammation and oxidative DNA damage.
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spelling pubmed-91458682022-05-29 Potential Chemotherapeutic Effect of Selenium for Improved Canceration of Esophageal Cancer Ahsan, Anil Liu, Zhiwei Su, Ruibing Liu, Chencai Liao, Xiaoqi Su, Min Int J Mol Sci Article Esophageal squamous cell carcinoma is the most common type of esophageal cancer and accounts for 5% of malignant tumor deaths. Recent research suggests that chronic inflammation and DNA damage may drive the onset of esophageal squamous cell carcinoma, implying that lowering chronic inflammation and DNA damage compounds may provide chemo-prevention. According to epidemiological and experimental evidence, selenium is linked to a lower risk of several malignancies, including esophageal squamous cell carcinoma. However, its exact mechanism is still unclear. In the present study, we used cell lines and a 4-NQO mice model to explore the anti-cancer mechanism of four types of selenium. Our findings indicated that selenium inhibited the proliferation, colony formation, and ROS level of ESCC cell lines in a time-dependent manner. Intriguingly, selenium treatment impeded 4-NQO-induced high-grade intraepithelial neoplasia and reduced the number of positive inflammatory cells by preserving DNA from oxidative damage. In addition, selenium significantly decreased the expression of Ki-67 and induced apoptosis. This study demonstrates that selenium has a significant chemo-preventive effect on ESCC by reducing high-grade dysplasia to low-grade dysplasia. For the first time, selenium was shown to slow down the progression of esophageal cancer by lowering inflammation and oxidative DNA damage. MDPI 2022-05-14 /pmc/articles/PMC9145868/ /pubmed/35628320 http://dx.doi.org/10.3390/ijms23105509 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ahsan, Anil
Liu, Zhiwei
Su, Ruibing
Liu, Chencai
Liao, Xiaoqi
Su, Min
Potential Chemotherapeutic Effect of Selenium for Improved Canceration of Esophageal Cancer
title Potential Chemotherapeutic Effect of Selenium for Improved Canceration of Esophageal Cancer
title_full Potential Chemotherapeutic Effect of Selenium for Improved Canceration of Esophageal Cancer
title_fullStr Potential Chemotherapeutic Effect of Selenium for Improved Canceration of Esophageal Cancer
title_full_unstemmed Potential Chemotherapeutic Effect of Selenium for Improved Canceration of Esophageal Cancer
title_short Potential Chemotherapeutic Effect of Selenium for Improved Canceration of Esophageal Cancer
title_sort potential chemotherapeutic effect of selenium for improved canceration of esophageal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145868/
https://www.ncbi.nlm.nih.gov/pubmed/35628320
http://dx.doi.org/10.3390/ijms23105509
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