Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control Measures

This cross-sectional study aimed to investigate the prevalence and risk factors of Hepatitis B virus infection among Japanese immigrants and their descendants from São Paulo (SP), and to verify the occurrence of occult hepatitis B and coinfection with HCV, Delta, and HTLV. All samples (n = 2.127) we...

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Detalles Bibliográficos
Autores principales: Demarchi, Luiz Henrique Ferraz, Bandeira, Larissa Melo, Taira, Deborah Ledesma, Zardin, Marina Castilhos Souza Umaki, Ibanhes, Mary Luizia, Esposito, Ana Olivia Pascoto, de Arruda, Larissa Domingues Castilho, Gonçalves, Crhistinne Cavalheiro Maymone, Weis-Torres, Sabrina Moreira dos Santos, Cesar, Gabriela Alves, da Cunha, Rivaldo Venâncio, Tanaka, Tayana Serpa Ortiz, Puga, Marco Antonio Moreira, de Rezende, Grazielli Rocha, Lopes, Roberta Barbosa, Uehara, Silvia Naomi de Oliveira, Pinho, João Renato Rebello, Carrilho, Flair Jose, Gomes-Gouvêa, Michele Soares, Motta-Castro, Ana Rita Coimbra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145874/
https://www.ncbi.nlm.nih.gov/pubmed/35632826
http://dx.doi.org/10.3390/v14051085
Descripción
Sumario:This cross-sectional study aimed to investigate the prevalence and risk factors of Hepatitis B virus infection among Japanese immigrants and their descendants from São Paulo (SP), and to verify the occurrence of occult hepatitis B and coinfection with HCV, Delta, and HTLV. All samples (n = 2.127) were tested for HBV serological markers by electrochemiluminescence. HBsAg and/or total anti-HBc positive samples were tested for HBV DNA by real-time PCR, and genotyped by sequencing using the Sanger methodology. The prevalence rate of HBV exposure was 13.4% (CI 95%: 11.9–14.9%), and 22 (1.1%) were HBsAg positive. A high rate of susceptibility to HBV infection was found (67.4%; CI 95%: 65.4–69.4%). In contrast, only 19.2% (CI 95%: 17.6–20.9%) presented a serological profile analogous to that elicited by Hepatitis B vaccination. HBV isolates (n = 8) were classified as genotypes HBV/B1 (62.5%), HBV/C2 (12.5%), HBV/F1b (12.5%), and HBV/A1 (12.5%). Hepatitis B vaccination strategies and educational measures to control this infection should be considered.

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