Cargando…

Association of Circulating IgE and CML Levels with In-Stent Restenosis in Type 2 Diabetic Patients with Stable Coronary Artery Disease

Background: We investigated whether serum levels of immunoglobin (Ig) E and Nε-carboxymethyl-lysine (CML) are related to in-stent restenosis (ISR) in patients with stable coronary artery disease and type 2 diabetes mellitus (T2DM). Methods: Serum levels of IgE and CML were measured in 196 ISR patien...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Jingmeng, Chen, Qiujing, Lu, Lin, Jin, Qi, Bao, Yangyang, Ling, Tianyou, Lin, Changjian, Ding, Fenghua, Wang, Xiaoqun, Shen, Weifeng, Shen, Ying, Dai, Yang, Wu, Liqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145878/
https://www.ncbi.nlm.nih.gov/pubmed/35621868
http://dx.doi.org/10.3390/jcdd9050157
_version_ 1784716423531069440
author Liu, Jingmeng
Chen, Qiujing
Lu, Lin
Jin, Qi
Bao, Yangyang
Ling, Tianyou
Lin, Changjian
Ding, Fenghua
Wang, Xiaoqun
Shen, Weifeng
Shen, Ying
Dai, Yang
Wu, Liqun
author_facet Liu, Jingmeng
Chen, Qiujing
Lu, Lin
Jin, Qi
Bao, Yangyang
Ling, Tianyou
Lin, Changjian
Ding, Fenghua
Wang, Xiaoqun
Shen, Weifeng
Shen, Ying
Dai, Yang
Wu, Liqun
author_sort Liu, Jingmeng
collection PubMed
description Background: We investigated whether serum levels of immunoglobin (Ig) E and Nε-carboxymethyl-lysine (CML) are related to in-stent restenosis (ISR) in patients with stable coronary artery disease and type 2 diabetes mellitus (T2DM). Methods: Serum levels of IgE and CML were measured in 196 ISR patients and 220 non-ISR patients with stable angina and T2DM who received angiographic follow-up 12 months after percutaneous coronary intervention (PCI) with third-generation drug-eluting stent (DES) implantation for de novo lesions. Multivariate logistic regression analysis was performed to assess the association between IgE or CML and ISR. Results: Both IgE and CML levels were higher in patients with ISR compared with non-ISR patients (IgE: 187.10 (63.75–489.65) vs. 80.25 (30.65–202.50), p < 0.001; CML: 203.26 (164.50–266.84) vs. 174.26 (130.85–215.56), p < 0.001). The rate of ISR increased stepwise with increasing tertiles of IgE and CML levels (p for all trends < 0.001), and IgE correlated significantly with CML. After adjusting for potential confounders, IgE and CML levels remained independently associated with ISR. Moreover, IgE and CML levels improved the predictive capability of traditional risk factors for ISR, and there existed an interaction between IgE and CML in relation to ISR (p for interaction < 0.01). Conclusion: Elevated circulating IgE and CML levels confer an increased risk for ISR after DES-based PCI in type 2 diabetic patients with stable coronary artery disease.
format Online
Article
Text
id pubmed-9145878
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91458782022-05-29 Association of Circulating IgE and CML Levels with In-Stent Restenosis in Type 2 Diabetic Patients with Stable Coronary Artery Disease Liu, Jingmeng Chen, Qiujing Lu, Lin Jin, Qi Bao, Yangyang Ling, Tianyou Lin, Changjian Ding, Fenghua Wang, Xiaoqun Shen, Weifeng Shen, Ying Dai, Yang Wu, Liqun J Cardiovasc Dev Dis Article Background: We investigated whether serum levels of immunoglobin (Ig) E and Nε-carboxymethyl-lysine (CML) are related to in-stent restenosis (ISR) in patients with stable coronary artery disease and type 2 diabetes mellitus (T2DM). Methods: Serum levels of IgE and CML were measured in 196 ISR patients and 220 non-ISR patients with stable angina and T2DM who received angiographic follow-up 12 months after percutaneous coronary intervention (PCI) with third-generation drug-eluting stent (DES) implantation for de novo lesions. Multivariate logistic regression analysis was performed to assess the association between IgE or CML and ISR. Results: Both IgE and CML levels were higher in patients with ISR compared with non-ISR patients (IgE: 187.10 (63.75–489.65) vs. 80.25 (30.65–202.50), p < 0.001; CML: 203.26 (164.50–266.84) vs. 174.26 (130.85–215.56), p < 0.001). The rate of ISR increased stepwise with increasing tertiles of IgE and CML levels (p for all trends < 0.001), and IgE correlated significantly with CML. After adjusting for potential confounders, IgE and CML levels remained independently associated with ISR. Moreover, IgE and CML levels improved the predictive capability of traditional risk factors for ISR, and there existed an interaction between IgE and CML in relation to ISR (p for interaction < 0.01). Conclusion: Elevated circulating IgE and CML levels confer an increased risk for ISR after DES-based PCI in type 2 diabetic patients with stable coronary artery disease. MDPI 2022-05-13 /pmc/articles/PMC9145878/ /pubmed/35621868 http://dx.doi.org/10.3390/jcdd9050157 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Jingmeng
Chen, Qiujing
Lu, Lin
Jin, Qi
Bao, Yangyang
Ling, Tianyou
Lin, Changjian
Ding, Fenghua
Wang, Xiaoqun
Shen, Weifeng
Shen, Ying
Dai, Yang
Wu, Liqun
Association of Circulating IgE and CML Levels with In-Stent Restenosis in Type 2 Diabetic Patients with Stable Coronary Artery Disease
title Association of Circulating IgE and CML Levels with In-Stent Restenosis in Type 2 Diabetic Patients with Stable Coronary Artery Disease
title_full Association of Circulating IgE and CML Levels with In-Stent Restenosis in Type 2 Diabetic Patients with Stable Coronary Artery Disease
title_fullStr Association of Circulating IgE and CML Levels with In-Stent Restenosis in Type 2 Diabetic Patients with Stable Coronary Artery Disease
title_full_unstemmed Association of Circulating IgE and CML Levels with In-Stent Restenosis in Type 2 Diabetic Patients with Stable Coronary Artery Disease
title_short Association of Circulating IgE and CML Levels with In-Stent Restenosis in Type 2 Diabetic Patients with Stable Coronary Artery Disease
title_sort association of circulating ige and cml levels with in-stent restenosis in type 2 diabetic patients with stable coronary artery disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145878/
https://www.ncbi.nlm.nih.gov/pubmed/35621868
http://dx.doi.org/10.3390/jcdd9050157
work_keys_str_mv AT liujingmeng associationofcirculatingigeandcmllevelswithinstentrestenosisintype2diabeticpatientswithstablecoronaryarterydisease
AT chenqiujing associationofcirculatingigeandcmllevelswithinstentrestenosisintype2diabeticpatientswithstablecoronaryarterydisease
AT lulin associationofcirculatingigeandcmllevelswithinstentrestenosisintype2diabeticpatientswithstablecoronaryarterydisease
AT jinqi associationofcirculatingigeandcmllevelswithinstentrestenosisintype2diabeticpatientswithstablecoronaryarterydisease
AT baoyangyang associationofcirculatingigeandcmllevelswithinstentrestenosisintype2diabeticpatientswithstablecoronaryarterydisease
AT lingtianyou associationofcirculatingigeandcmllevelswithinstentrestenosisintype2diabeticpatientswithstablecoronaryarterydisease
AT linchangjian associationofcirculatingigeandcmllevelswithinstentrestenosisintype2diabeticpatientswithstablecoronaryarterydisease
AT dingfenghua associationofcirculatingigeandcmllevelswithinstentrestenosisintype2diabeticpatientswithstablecoronaryarterydisease
AT wangxiaoqun associationofcirculatingigeandcmllevelswithinstentrestenosisintype2diabeticpatientswithstablecoronaryarterydisease
AT shenweifeng associationofcirculatingigeandcmllevelswithinstentrestenosisintype2diabeticpatientswithstablecoronaryarterydisease
AT shenying associationofcirculatingigeandcmllevelswithinstentrestenosisintype2diabeticpatientswithstablecoronaryarterydisease
AT daiyang associationofcirculatingigeandcmllevelswithinstentrestenosisintype2diabeticpatientswithstablecoronaryarterydisease
AT wuliqun associationofcirculatingigeandcmllevelswithinstentrestenosisintype2diabeticpatientswithstablecoronaryarterydisease