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Approach to Thrombophilia in Pregnancy—A Narrative Review
Thrombophilia is a genetic predisposition to hypercoagulable states caused by acquired haemostasis conditions; pregnancy causes the haemostatic system to become hypercoagulable, which grows throughout the pregnancy and peaks around delivery. Genetic testing for thrombophilic gene mutations is evalua...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145888/ https://www.ncbi.nlm.nih.gov/pubmed/35630108 http://dx.doi.org/10.3390/medicina58050692 |
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author | Samfireag, Miruna Potre, Cristina Potre, Ovidiu Tudor, Raluca Hoinoiu, Teodora Anghel, Andrei |
author_facet | Samfireag, Miruna Potre, Cristina Potre, Ovidiu Tudor, Raluca Hoinoiu, Teodora Anghel, Andrei |
author_sort | Samfireag, Miruna |
collection | PubMed |
description | Thrombophilia is a genetic predisposition to hypercoagulable states caused by acquired haemostasis conditions; pregnancy causes the haemostatic system to become hypercoagulable, which grows throughout the pregnancy and peaks around delivery. Genetic testing for thrombophilic gene mutations is evaluated using different methodologies of real-time polymerase chain reaction and DNA microarrays of specific genes. Adapting the general care of the pregnant woman to the particularities caused by thrombophilia is an important component, so screening is preferred to assess the degree of genetic damage that manifests itself as a risk of thrombosis. The major goal of this narrative review was to quantitatively evaluate the literature data on the specific care of pregnant women with thrombophilia that are at risk of developing unplanned miscarriages. |
format | Online Article Text |
id | pubmed-9145888 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91458882022-05-29 Approach to Thrombophilia in Pregnancy—A Narrative Review Samfireag, Miruna Potre, Cristina Potre, Ovidiu Tudor, Raluca Hoinoiu, Teodora Anghel, Andrei Medicina (Kaunas) Review Thrombophilia is a genetic predisposition to hypercoagulable states caused by acquired haemostasis conditions; pregnancy causes the haemostatic system to become hypercoagulable, which grows throughout the pregnancy and peaks around delivery. Genetic testing for thrombophilic gene mutations is evaluated using different methodologies of real-time polymerase chain reaction and DNA microarrays of specific genes. Adapting the general care of the pregnant woman to the particularities caused by thrombophilia is an important component, so screening is preferred to assess the degree of genetic damage that manifests itself as a risk of thrombosis. The major goal of this narrative review was to quantitatively evaluate the literature data on the specific care of pregnant women with thrombophilia that are at risk of developing unplanned miscarriages. MDPI 2022-05-23 /pmc/articles/PMC9145888/ /pubmed/35630108 http://dx.doi.org/10.3390/medicina58050692 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Samfireag, Miruna Potre, Cristina Potre, Ovidiu Tudor, Raluca Hoinoiu, Teodora Anghel, Andrei Approach to Thrombophilia in Pregnancy—A Narrative Review |
title | Approach to Thrombophilia in Pregnancy—A Narrative Review |
title_full | Approach to Thrombophilia in Pregnancy—A Narrative Review |
title_fullStr | Approach to Thrombophilia in Pregnancy—A Narrative Review |
title_full_unstemmed | Approach to Thrombophilia in Pregnancy—A Narrative Review |
title_short | Approach to Thrombophilia in Pregnancy—A Narrative Review |
title_sort | approach to thrombophilia in pregnancy—a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145888/ https://www.ncbi.nlm.nih.gov/pubmed/35630108 http://dx.doi.org/10.3390/medicina58050692 |
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