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Approach to Thrombophilia in Pregnancy—A Narrative Review

Thrombophilia is a genetic predisposition to hypercoagulable states caused by acquired haemostasis conditions; pregnancy causes the haemostatic system to become hypercoagulable, which grows throughout the pregnancy and peaks around delivery. Genetic testing for thrombophilic gene mutations is evalua...

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Autores principales: Samfireag, Miruna, Potre, Cristina, Potre, Ovidiu, Tudor, Raluca, Hoinoiu, Teodora, Anghel, Andrei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145888/
https://www.ncbi.nlm.nih.gov/pubmed/35630108
http://dx.doi.org/10.3390/medicina58050692
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author Samfireag, Miruna
Potre, Cristina
Potre, Ovidiu
Tudor, Raluca
Hoinoiu, Teodora
Anghel, Andrei
author_facet Samfireag, Miruna
Potre, Cristina
Potre, Ovidiu
Tudor, Raluca
Hoinoiu, Teodora
Anghel, Andrei
author_sort Samfireag, Miruna
collection PubMed
description Thrombophilia is a genetic predisposition to hypercoagulable states caused by acquired haemostasis conditions; pregnancy causes the haemostatic system to become hypercoagulable, which grows throughout the pregnancy and peaks around delivery. Genetic testing for thrombophilic gene mutations is evaluated using different methodologies of real-time polymerase chain reaction and DNA microarrays of specific genes. Adapting the general care of the pregnant woman to the particularities caused by thrombophilia is an important component, so screening is preferred to assess the degree of genetic damage that manifests itself as a risk of thrombosis. The major goal of this narrative review was to quantitatively evaluate the literature data on the specific care of pregnant women with thrombophilia that are at risk of developing unplanned miscarriages.
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spelling pubmed-91458882022-05-29 Approach to Thrombophilia in Pregnancy—A Narrative Review Samfireag, Miruna Potre, Cristina Potre, Ovidiu Tudor, Raluca Hoinoiu, Teodora Anghel, Andrei Medicina (Kaunas) Review Thrombophilia is a genetic predisposition to hypercoagulable states caused by acquired haemostasis conditions; pregnancy causes the haemostatic system to become hypercoagulable, which grows throughout the pregnancy and peaks around delivery. Genetic testing for thrombophilic gene mutations is evaluated using different methodologies of real-time polymerase chain reaction and DNA microarrays of specific genes. Adapting the general care of the pregnant woman to the particularities caused by thrombophilia is an important component, so screening is preferred to assess the degree of genetic damage that manifests itself as a risk of thrombosis. The major goal of this narrative review was to quantitatively evaluate the literature data on the specific care of pregnant women with thrombophilia that are at risk of developing unplanned miscarriages. MDPI 2022-05-23 /pmc/articles/PMC9145888/ /pubmed/35630108 http://dx.doi.org/10.3390/medicina58050692 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Samfireag, Miruna
Potre, Cristina
Potre, Ovidiu
Tudor, Raluca
Hoinoiu, Teodora
Anghel, Andrei
Approach to Thrombophilia in Pregnancy—A Narrative Review
title Approach to Thrombophilia in Pregnancy—A Narrative Review
title_full Approach to Thrombophilia in Pregnancy—A Narrative Review
title_fullStr Approach to Thrombophilia in Pregnancy—A Narrative Review
title_full_unstemmed Approach to Thrombophilia in Pregnancy—A Narrative Review
title_short Approach to Thrombophilia in Pregnancy—A Narrative Review
title_sort approach to thrombophilia in pregnancy—a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145888/
https://www.ncbi.nlm.nih.gov/pubmed/35630108
http://dx.doi.org/10.3390/medicina58050692
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