Machine-Learning Guided Discovery of Bioactive Inhibitors of PD1-PDL1 Interaction

The selective activation of the innate immune system through blockade of immune checkpoint PD1-PDL1 interaction has proven effective against a variety of cancers. In contrast to six antibody therapies approved and several under clinical investigation, the development of small-molecule PD1-PDL1 inhib...

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Detalles Bibliográficos
Autores principales: Patil, Sachin P., Fattakhova, Elena, Hofer, Jeremy, Oravic, Michael, Bender, Autumn, Brearey, Jason, Parker, Daniel, Radnoff, Madison, Smith, Zackary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145945/
https://www.ncbi.nlm.nih.gov/pubmed/35631439
http://dx.doi.org/10.3390/ph15050613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145945/
https://www.ncbi.nlm.nih.gov/pubmed/35631439
http://dx.doi.org/10.3390/ph15050613

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