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Machine-Learning Guided Discovery of Bioactive Inhibitors of PD1-PDL1 Interaction

The selective activation of the innate immune system through blockade of immune checkpoint PD1-PDL1 interaction has proven effective against a variety of cancers. In contrast to six antibody therapies approved and several under clinical investigation, the development of small-molecule PD1-PDL1 inhib...

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Detalles Bibliográficos
Autores principales:	Patil, Sachin P., Fattakhova, Elena, Hofer, Jeremy, Oravic, Michael, Bender, Autumn, Brearey, Jason, Parker, Daniel, Radnoff, Madison, Smith, Zackary
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145945/ https://www.ncbi.nlm.nih.gov/pubmed/35631439 http://dx.doi.org/10.3390/ph15050613

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