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Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?

During the last two decades several nanoscale materials were engineered for industrial and medical applications. Among them carbon nanotubes (CNTs) are the most exploited nanomaterials with global production of around 1000 tons/year. Besides several commercial benefits of CNTs, the fiber-like struct...

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Autores principales: Gupta, Suchi Smita, Singh, Krishna P., Gupta, Shailendra, Dusinska, Maria, Rahman, Qamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145953/
https://www.ncbi.nlm.nih.gov/pubmed/35630938
http://dx.doi.org/10.3390/nano12101708
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author Gupta, Suchi Smita
Singh, Krishna P.
Gupta, Shailendra
Dusinska, Maria
Rahman, Qamar
author_facet Gupta, Suchi Smita
Singh, Krishna P.
Gupta, Shailendra
Dusinska, Maria
Rahman, Qamar
author_sort Gupta, Suchi Smita
collection PubMed
description During the last two decades several nanoscale materials were engineered for industrial and medical applications. Among them carbon nanotubes (CNTs) are the most exploited nanomaterials with global production of around 1000 tons/year. Besides several commercial benefits of CNTs, the fiber-like structures and their bio-persistency in lung tissues raise serious concerns about the possible adverse human health effects resembling those of asbestos fibers. In this review, we present a comparative analysis between CNTs and asbestos fibers using the following four parameters: (1) fibrous needle-like shape, (2) bio-persistent nature, (3) high surface to volume ratio and (4) capacity to adsorb toxicants/pollutants on the surface. We also compare mechanisms underlying the toxicity caused by certain diameters and lengths of CNTs and asbestos fibers using downstream pathways associated with altered gene expression data from both asbestos and CNT exposure. Our results suggest that indeed certain types of CNTs are emulating asbestos fiber as far as associated toxicity is concerned.
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spelling pubmed-91459532022-05-29 Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms? Gupta, Suchi Smita Singh, Krishna P. Gupta, Shailendra Dusinska, Maria Rahman, Qamar Nanomaterials (Basel) Review During the last two decades several nanoscale materials were engineered for industrial and medical applications. Among them carbon nanotubes (CNTs) are the most exploited nanomaterials with global production of around 1000 tons/year. Besides several commercial benefits of CNTs, the fiber-like structures and their bio-persistency in lung tissues raise serious concerns about the possible adverse human health effects resembling those of asbestos fibers. In this review, we present a comparative analysis between CNTs and asbestos fibers using the following four parameters: (1) fibrous needle-like shape, (2) bio-persistent nature, (3) high surface to volume ratio and (4) capacity to adsorb toxicants/pollutants on the surface. We also compare mechanisms underlying the toxicity caused by certain diameters and lengths of CNTs and asbestos fibers using downstream pathways associated with altered gene expression data from both asbestos and CNT exposure. Our results suggest that indeed certain types of CNTs are emulating asbestos fiber as far as associated toxicity is concerned. MDPI 2022-05-17 /pmc/articles/PMC9145953/ /pubmed/35630938 http://dx.doi.org/10.3390/nano12101708 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gupta, Suchi Smita
Singh, Krishna P.
Gupta, Shailendra
Dusinska, Maria
Rahman, Qamar
Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?
title Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?
title_full Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?
title_fullStr Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?
title_full_unstemmed Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?
title_short Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?
title_sort do carbon nanotubes and asbestos fibers exhibit common toxicity mechanisms?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145953/
https://www.ncbi.nlm.nih.gov/pubmed/35630938
http://dx.doi.org/10.3390/nano12101708
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