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The Development of Novel Drug Treatments for Stroke Patients: A Review
Acute ischemic stroke is a critical condition that can result in disability and death. The consequences of this medical condition depend on various factors, including the size of the stroke, affected brain region, treatment onset, and the type of treatment. The primary objective of stroke treatment...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145977/ https://www.ncbi.nlm.nih.gov/pubmed/35628606 http://dx.doi.org/10.3390/ijms23105796 |
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author | Frank, Dmitry Zlotnik, Alexander Boyko, Matthew Gruenbaum, Benjamin Fredrick |
author_facet | Frank, Dmitry Zlotnik, Alexander Boyko, Matthew Gruenbaum, Benjamin Fredrick |
author_sort | Frank, Dmitry |
collection | PubMed |
description | Acute ischemic stroke is a critical condition that can result in disability and death. The consequences of this medical condition depend on various factors, including the size of the stroke, affected brain region, treatment onset, and the type of treatment. The primary objective of stroke treatment is to restart ischemic penumbra tissue perfusion and reduce infarct volume by sustaining blood flow. Recent research on the condition’s pathological pathways and processes has significantly improved treatment options beyond restoring perfusion. Many studies have concentrated on limiting injury severity via the manipulation of molecular mechanisms of ischemia, particularly in animal research. This article reviews completed and ongoing research on the development of acute ischemic stroke drugs. This study focuses on three main categories of antithrombotic drugs, thrombolytic drugs, and neuroprotective agents. The paper outlines findings from animal and clinical trials and explores the working mechanisms of these drugs. |
format | Online Article Text |
id | pubmed-9145977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91459772022-05-29 The Development of Novel Drug Treatments for Stroke Patients: A Review Frank, Dmitry Zlotnik, Alexander Boyko, Matthew Gruenbaum, Benjamin Fredrick Int J Mol Sci Review Acute ischemic stroke is a critical condition that can result in disability and death. The consequences of this medical condition depend on various factors, including the size of the stroke, affected brain region, treatment onset, and the type of treatment. The primary objective of stroke treatment is to restart ischemic penumbra tissue perfusion and reduce infarct volume by sustaining blood flow. Recent research on the condition’s pathological pathways and processes has significantly improved treatment options beyond restoring perfusion. Many studies have concentrated on limiting injury severity via the manipulation of molecular mechanisms of ischemia, particularly in animal research. This article reviews completed and ongoing research on the development of acute ischemic stroke drugs. This study focuses on three main categories of antithrombotic drugs, thrombolytic drugs, and neuroprotective agents. The paper outlines findings from animal and clinical trials and explores the working mechanisms of these drugs. MDPI 2022-05-21 /pmc/articles/PMC9145977/ /pubmed/35628606 http://dx.doi.org/10.3390/ijms23105796 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Frank, Dmitry Zlotnik, Alexander Boyko, Matthew Gruenbaum, Benjamin Fredrick The Development of Novel Drug Treatments for Stroke Patients: A Review |
title | The Development of Novel Drug Treatments for Stroke Patients: A Review |
title_full | The Development of Novel Drug Treatments for Stroke Patients: A Review |
title_fullStr | The Development of Novel Drug Treatments for Stroke Patients: A Review |
title_full_unstemmed | The Development of Novel Drug Treatments for Stroke Patients: A Review |
title_short | The Development of Novel Drug Treatments for Stroke Patients: A Review |
title_sort | development of novel drug treatments for stroke patients: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145977/ https://www.ncbi.nlm.nih.gov/pubmed/35628606 http://dx.doi.org/10.3390/ijms23105796 |
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