Cargando…
Mangifera indica ‘Namdokmai’ Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a Drosophila Model of Alzheimer’s Amyloidosis
Alzheimer’s disease (AD) is a progressive neurological illness with few effective treatments. Thus, ameliorating the effects of AD using natural products has attracted global attention with promising efficacy and safety. In this study, ten tropical fruits including Ananas comosus ‘Phulae’, Ananas co...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146065/ https://www.ncbi.nlm.nih.gov/pubmed/35631418 http://dx.doi.org/10.3390/ph15050591 |
_version_ | 1784716468775026688 |
---|---|
author | Temviriyanukul, Piya Kittibunchakul, Suwapat Trisonthi, Piyapat Kunkeaw, Thanit Inthachat, Woorawee Siriwan, Dalad Suttisansanee, Uthaiwan |
author_facet | Temviriyanukul, Piya Kittibunchakul, Suwapat Trisonthi, Piyapat Kunkeaw, Thanit Inthachat, Woorawee Siriwan, Dalad Suttisansanee, Uthaiwan |
author_sort | Temviriyanukul, Piya |
collection | PubMed |
description | Alzheimer’s disease (AD) is a progressive neurological illness with few effective treatments. Thus, ameliorating the effects of AD using natural products has attracted global attention with promising efficacy and safety. In this study, ten tropical fruits including Ananas comosus ‘Phulae’, Ananas comosus ‘Pattavia’, Carica papaya ‘Khaekdum’, Carica papaya ‘Khaeknuan’, Durio zibethinus ‘Monthong’, Durio zibethinus ‘Chanee’, Psidium guajava ‘Kimju’, Psidium guajava ‘Keenok’, Mangifera indica ‘Kaew’ and Mangifera indica ‘Namdokmai’ were screened for their inhibitory activities against the key enzymes, cholinesterases and β-secretase (BACE-1), involved in AD pathogenesis. The top three fruit extracts with promising in vitro anti-AD activities were further investigated using rat pheochromocytoma PC-12 neuronal cell line and Drosophila AD model. Data showed that M. indica ‘Kaew’, M. indica ‘Namdokmai’ and P. guajava ‘Kimju’ reduced Aβ(1–42)-mediated neurotoxicity by promoting glutathione-dependent enzymes, while M. indica ‘Namdokmai’ limited Aβ(1–42) peptide formation via BACE-1 inhibition and amended locomotory behavior of the Drosophila AD model. Results indicated the potential anti-AD properties of tropical fruits, particularly M. indica ‘Namdokmai’ in the prevention of Aβ(1–42)-mediated neurotoxicity and as a BACE-1 blocker. |
format | Online Article Text |
id | pubmed-9146065 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91460652022-05-29 Mangifera indica ‘Namdokmai’ Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a Drosophila Model of Alzheimer’s Amyloidosis Temviriyanukul, Piya Kittibunchakul, Suwapat Trisonthi, Piyapat Kunkeaw, Thanit Inthachat, Woorawee Siriwan, Dalad Suttisansanee, Uthaiwan Pharmaceuticals (Basel) Article Alzheimer’s disease (AD) is a progressive neurological illness with few effective treatments. Thus, ameliorating the effects of AD using natural products has attracted global attention with promising efficacy and safety. In this study, ten tropical fruits including Ananas comosus ‘Phulae’, Ananas comosus ‘Pattavia’, Carica papaya ‘Khaekdum’, Carica papaya ‘Khaeknuan’, Durio zibethinus ‘Monthong’, Durio zibethinus ‘Chanee’, Psidium guajava ‘Kimju’, Psidium guajava ‘Keenok’, Mangifera indica ‘Kaew’ and Mangifera indica ‘Namdokmai’ were screened for their inhibitory activities against the key enzymes, cholinesterases and β-secretase (BACE-1), involved in AD pathogenesis. The top three fruit extracts with promising in vitro anti-AD activities were further investigated using rat pheochromocytoma PC-12 neuronal cell line and Drosophila AD model. Data showed that M. indica ‘Kaew’, M. indica ‘Namdokmai’ and P. guajava ‘Kimju’ reduced Aβ(1–42)-mediated neurotoxicity by promoting glutathione-dependent enzymes, while M. indica ‘Namdokmai’ limited Aβ(1–42) peptide formation via BACE-1 inhibition and amended locomotory behavior of the Drosophila AD model. Results indicated the potential anti-AD properties of tropical fruits, particularly M. indica ‘Namdokmai’ in the prevention of Aβ(1–42)-mediated neurotoxicity and as a BACE-1 blocker. MDPI 2022-05-11 /pmc/articles/PMC9146065/ /pubmed/35631418 http://dx.doi.org/10.3390/ph15050591 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Temviriyanukul, Piya Kittibunchakul, Suwapat Trisonthi, Piyapat Kunkeaw, Thanit Inthachat, Woorawee Siriwan, Dalad Suttisansanee, Uthaiwan Mangifera indica ‘Namdokmai’ Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a Drosophila Model of Alzheimer’s Amyloidosis |
title | Mangifera indica ‘Namdokmai’ Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a Drosophila Model of Alzheimer’s Amyloidosis |
title_full | Mangifera indica ‘Namdokmai’ Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a Drosophila Model of Alzheimer’s Amyloidosis |
title_fullStr | Mangifera indica ‘Namdokmai’ Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a Drosophila Model of Alzheimer’s Amyloidosis |
title_full_unstemmed | Mangifera indica ‘Namdokmai’ Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a Drosophila Model of Alzheimer’s Amyloidosis |
title_short | Mangifera indica ‘Namdokmai’ Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a Drosophila Model of Alzheimer’s Amyloidosis |
title_sort | mangifera indica ‘namdokmai’ prevents neuronal cells from amyloid peptide toxicity and inhibits bace-1 activities in a drosophila model of alzheimer’s amyloidosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146065/ https://www.ncbi.nlm.nih.gov/pubmed/35631418 http://dx.doi.org/10.3390/ph15050591 |
work_keys_str_mv | AT temviriyanukulpiya mangiferaindicanamdokmaipreventsneuronalcellsfromamyloidpeptidetoxicityandinhibitsbace1activitiesinadrosophilamodelofalzheimersamyloidosis AT kittibunchakulsuwapat mangiferaindicanamdokmaipreventsneuronalcellsfromamyloidpeptidetoxicityandinhibitsbace1activitiesinadrosophilamodelofalzheimersamyloidosis AT trisonthipiyapat mangiferaindicanamdokmaipreventsneuronalcellsfromamyloidpeptidetoxicityandinhibitsbace1activitiesinadrosophilamodelofalzheimersamyloidosis AT kunkeawthanit mangiferaindicanamdokmaipreventsneuronalcellsfromamyloidpeptidetoxicityandinhibitsbace1activitiesinadrosophilamodelofalzheimersamyloidosis AT inthachatwoorawee mangiferaindicanamdokmaipreventsneuronalcellsfromamyloidpeptidetoxicityandinhibitsbace1activitiesinadrosophilamodelofalzheimersamyloidosis AT siriwandalad mangiferaindicanamdokmaipreventsneuronalcellsfromamyloidpeptidetoxicityandinhibitsbace1activitiesinadrosophilamodelofalzheimersamyloidosis AT suttisansaneeuthaiwan mangiferaindicanamdokmaipreventsneuronalcellsfromamyloidpeptidetoxicityandinhibitsbace1activitiesinadrosophilamodelofalzheimersamyloidosis |