Synthesis, Redox and Spectroscopic Properties of Pterin of Molybdenum Cofactors

Pterins are bicyclic heterocycles that are found widely across Nature and are involved in a variety of biological functions. Notably, pterins are found at the core of molybdenum cofactor (Moco) containing enzymes in the molybdopterin (MPT) ligand that coordinates molybdenum and facilitates cofactor...

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Detalles Bibliográficos
Autores principales: Colston, Kyle J., Basu, Partha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146068/
https://www.ncbi.nlm.nih.gov/pubmed/35630801
http://dx.doi.org/10.3390/molecules27103324
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author Colston, Kyle J.
Basu, Partha
author_facet Colston, Kyle J.
Basu, Partha
author_sort Colston, Kyle J.
collection PubMed
description Pterins are bicyclic heterocycles that are found widely across Nature and are involved in a variety of biological functions. Notably, pterins are found at the core of molybdenum cofactor (Moco) containing enzymes in the molybdopterin (MPT) ligand that coordinates molybdenum and facilitates cofactor activity. Pterins are diverse and can be widely functionalized to tune their properties. Herein, the general methods of synthesis, redox and spectroscopic properties of pterin are discussed to provide more insight into pterin chemistry and their importance to biological systems.
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spelling pubmed-91460682022-05-29 Synthesis, Redox and Spectroscopic Properties of Pterin of Molybdenum Cofactors Colston, Kyle J. Basu, Partha Molecules Review Pterins are bicyclic heterocycles that are found widely across Nature and are involved in a variety of biological functions. Notably, pterins are found at the core of molybdenum cofactor (Moco) containing enzymes in the molybdopterin (MPT) ligand that coordinates molybdenum and facilitates cofactor activity. Pterins are diverse and can be widely functionalized to tune their properties. Herein, the general methods of synthesis, redox and spectroscopic properties of pterin are discussed to provide more insight into pterin chemistry and their importance to biological systems. MDPI 2022-05-22 /pmc/articles/PMC9146068/ /pubmed/35630801 http://dx.doi.org/10.3390/molecules27103324 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Colston, Kyle J.
Basu, Partha
Synthesis, Redox and Spectroscopic Properties of Pterin of Molybdenum Cofactors
title Synthesis, Redox and Spectroscopic Properties of Pterin of Molybdenum Cofactors
title_full Synthesis, Redox and Spectroscopic Properties of Pterin of Molybdenum Cofactors
title_fullStr Synthesis, Redox and Spectroscopic Properties of Pterin of Molybdenum Cofactors
title_full_unstemmed Synthesis, Redox and Spectroscopic Properties of Pterin of Molybdenum Cofactors
title_short Synthesis, Redox and Spectroscopic Properties of Pterin of Molybdenum Cofactors
title_sort synthesis, redox and spectroscopic properties of pterin of molybdenum cofactors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146068/
https://www.ncbi.nlm.nih.gov/pubmed/35630801
http://dx.doi.org/10.3390/molecules27103324
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