Cargando…

The Impact of COVID Vaccination on Symptoms of Long COVID: An International Survey of People with Lived Experience of Long COVID

Long COVID is a multi-system syndrome following SARS-CoV-2 infection with persistent symptoms of at least 4 weeks, and frequently for several months. It has been suggested that there may be an autoimmune component. There has been an understandable caution amongst some people experiencing long COVID...

Descripción completa

Detalles Bibliográficos
Autores principales: Strain, William David, Sherwood, Ondine, Banerjee, Amitava, Van der Togt, Vicky, Hishmeh, Lyth, Rossman, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146071/
https://www.ncbi.nlm.nih.gov/pubmed/35632408
http://dx.doi.org/10.3390/vaccines10050652
_version_ 1784716470273441792
author Strain, William David
Sherwood, Ondine
Banerjee, Amitava
Van der Togt, Vicky
Hishmeh, Lyth
Rossman, Jeremy
author_facet Strain, William David
Sherwood, Ondine
Banerjee, Amitava
Van der Togt, Vicky
Hishmeh, Lyth
Rossman, Jeremy
author_sort Strain, William David
collection PubMed
description Long COVID is a multi-system syndrome following SARS-CoV-2 infection with persistent symptoms of at least 4 weeks, and frequently for several months. It has been suggested that there may be an autoimmune component. There has been an understandable caution amongst some people experiencing long COVID that, by boosting their immune response, a COVID vaccine may exacerbate their symptoms. We aimed to survey people living with long COVID, evaluating the impact of their first COVID vaccination on their symptoms. Methods: Patients with long COVID were invited to complete a web-based questionnaire through postings on social media and direct mailing from support groups. Basic demographics, range and severity of long COVID symptoms, before and after their vaccine, were surveyed. Results: 900 people participated in the questionnaire, of whom 45 had pre-existing myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) but no evidence of COVID infection, and a further 43 did not complete the survey in full. The demographics and symptomology of the remaining 812 people were similar to those recorded by the UK Office of National Statistics. Following vaccination, 57.9% of participants reported improvements in symptoms, 17.9% reported deterioration and the remainder no change. There was considerable individual variation in responses. Larger improvements in symptom severity scores were seen in those receiving the mRNA vaccines compared to adenoviral vector vaccines. Conclusions: Our survey suggests COVID-19 vaccination may improve long COVID patients, on average. The observational nature of the survey limits drawing direct causal inference, but requires validation with a randomised controlled trial.
format Online
Article
Text
id pubmed-9146071
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91460712022-05-29 The Impact of COVID Vaccination on Symptoms of Long COVID: An International Survey of People with Lived Experience of Long COVID Strain, William David Sherwood, Ondine Banerjee, Amitava Van der Togt, Vicky Hishmeh, Lyth Rossman, Jeremy Vaccines (Basel) Article Long COVID is a multi-system syndrome following SARS-CoV-2 infection with persistent symptoms of at least 4 weeks, and frequently for several months. It has been suggested that there may be an autoimmune component. There has been an understandable caution amongst some people experiencing long COVID that, by boosting their immune response, a COVID vaccine may exacerbate their symptoms. We aimed to survey people living with long COVID, evaluating the impact of their first COVID vaccination on their symptoms. Methods: Patients with long COVID were invited to complete a web-based questionnaire through postings on social media and direct mailing from support groups. Basic demographics, range and severity of long COVID symptoms, before and after their vaccine, were surveyed. Results: 900 people participated in the questionnaire, of whom 45 had pre-existing myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) but no evidence of COVID infection, and a further 43 did not complete the survey in full. The demographics and symptomology of the remaining 812 people were similar to those recorded by the UK Office of National Statistics. Following vaccination, 57.9% of participants reported improvements in symptoms, 17.9% reported deterioration and the remainder no change. There was considerable individual variation in responses. Larger improvements in symptom severity scores were seen in those receiving the mRNA vaccines compared to adenoviral vector vaccines. Conclusions: Our survey suggests COVID-19 vaccination may improve long COVID patients, on average. The observational nature of the survey limits drawing direct causal inference, but requires validation with a randomised controlled trial. MDPI 2022-04-21 /pmc/articles/PMC9146071/ /pubmed/35632408 http://dx.doi.org/10.3390/vaccines10050652 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Strain, William David
Sherwood, Ondine
Banerjee, Amitava
Van der Togt, Vicky
Hishmeh, Lyth
Rossman, Jeremy
The Impact of COVID Vaccination on Symptoms of Long COVID: An International Survey of People with Lived Experience of Long COVID
title The Impact of COVID Vaccination on Symptoms of Long COVID: An International Survey of People with Lived Experience of Long COVID
title_full The Impact of COVID Vaccination on Symptoms of Long COVID: An International Survey of People with Lived Experience of Long COVID
title_fullStr The Impact of COVID Vaccination on Symptoms of Long COVID: An International Survey of People with Lived Experience of Long COVID
title_full_unstemmed The Impact of COVID Vaccination on Symptoms of Long COVID: An International Survey of People with Lived Experience of Long COVID
title_short The Impact of COVID Vaccination on Symptoms of Long COVID: An International Survey of People with Lived Experience of Long COVID
title_sort impact of covid vaccination on symptoms of long covid: an international survey of people with lived experience of long covid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146071/
https://www.ncbi.nlm.nih.gov/pubmed/35632408
http://dx.doi.org/10.3390/vaccines10050652
work_keys_str_mv AT strainwilliamdavid theimpactofcovidvaccinationonsymptomsoflongcovidaninternationalsurveyofpeoplewithlivedexperienceoflongcovid
AT sherwoodondine theimpactofcovidvaccinationonsymptomsoflongcovidaninternationalsurveyofpeoplewithlivedexperienceoflongcovid
AT banerjeeamitava theimpactofcovidvaccinationonsymptomsoflongcovidaninternationalsurveyofpeoplewithlivedexperienceoflongcovid
AT vandertogtvicky theimpactofcovidvaccinationonsymptomsoflongcovidaninternationalsurveyofpeoplewithlivedexperienceoflongcovid
AT hishmehlyth theimpactofcovidvaccinationonsymptomsoflongcovidaninternationalsurveyofpeoplewithlivedexperienceoflongcovid
AT rossmanjeremy theimpactofcovidvaccinationonsymptomsoflongcovidaninternationalsurveyofpeoplewithlivedexperienceoflongcovid
AT strainwilliamdavid impactofcovidvaccinationonsymptomsoflongcovidaninternationalsurveyofpeoplewithlivedexperienceoflongcovid
AT sherwoodondine impactofcovidvaccinationonsymptomsoflongcovidaninternationalsurveyofpeoplewithlivedexperienceoflongcovid
AT banerjeeamitava impactofcovidvaccinationonsymptomsoflongcovidaninternationalsurveyofpeoplewithlivedexperienceoflongcovid
AT vandertogtvicky impactofcovidvaccinationonsymptomsoflongcovidaninternationalsurveyofpeoplewithlivedexperienceoflongcovid
AT hishmehlyth impactofcovidvaccinationonsymptomsoflongcovidaninternationalsurveyofpeoplewithlivedexperienceoflongcovid
AT rossmanjeremy impactofcovidvaccinationonsymptomsoflongcovidaninternationalsurveyofpeoplewithlivedexperienceoflongcovid