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Development of Extended-Release Mini-Tablets Containing Metoprolol Supported by Design of Experiments and Physiologically Based Biopharmaceutics Modeling

The development of extended-release dosage forms with adequate drug release is a challenge for pharmaceutical companies, mainly when the drug presents high solubility, as in Biopharmaceutics Classification System (BCS) class I. This study aimed to develop extended-release mini-tablets containing met...

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Detalles Bibliográficos
Autores principales:	Issa, Michele Georges, de Souza, Natalia Vieira, Jou, Bruna Wenyi Chuang, Duque, Marcelo Dutra, Ferraz, Humberto Gomes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146084/ https://www.ncbi.nlm.nih.gov/pubmed/35631478 http://dx.doi.org/10.3390/pharmaceutics14050892

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