Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers

An easy and viable crosslinking procedure by click-chemistry (click-crosslinking) of hyaluronic acid (HA) was developed. In particular, the clickable propargyl groups of hyaluronane-based HA-FA-Pg graft copolymers showing low and medium molecular weight values were exploited in crosslinking by click...

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Detalles Bibliográficos
Autores principales: Saletti, Mario, Paolino, Marco, Ballerini, Lavinia, Giuliani, Germano, Leone, Gemma, Lamponi, Stefania, Andreassi, Marco, Bonechi, Claudia, Donati, Alessandro, Piovani, Daniele, Schieroni, Alberto Giacometti, Magnani, Agnese, Cappelli, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146110/
https://www.ncbi.nlm.nih.gov/pubmed/35631626
http://dx.doi.org/10.3390/pharmaceutics14051041
Descripción
Sumario:An easy and viable crosslinking procedure by click-chemistry (click-crosslinking) of hyaluronic acid (HA) was developed. In particular, the clickable propargyl groups of hyaluronane-based HA-FA-Pg graft copolymers showing low and medium molecular weight values were exploited in crosslinking by click-chemistry by using a hexa(ethylene glycol) spacer. The resulting HA-FA-HEG-CL materials showed an apparent lack of in vitro cytotoxic effects, tuneable water affinity, and rheological properties according to the crosslinking degree that suggests their applicability in different biomedical fields.

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