Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers

An easy and viable crosslinking procedure by click-chemistry (click-crosslinking) of hyaluronic acid (HA) was developed. In particular, the clickable propargyl groups of hyaluronane-based HA-FA-Pg graft copolymers showing low and medium molecular weight values were exploited in crosslinking by click...

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Autores principales: Saletti, Mario, Paolino, Marco, Ballerini, Lavinia, Giuliani, Germano, Leone, Gemma, Lamponi, Stefania, Andreassi, Marco, Bonechi, Claudia, Donati, Alessandro, Piovani, Daniele, Schieroni, Alberto Giacometti, Magnani, Agnese, Cappelli, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146110/
https://www.ncbi.nlm.nih.gov/pubmed/35631626
http://dx.doi.org/10.3390/pharmaceutics14051041
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author Saletti, Mario
Paolino, Marco
Ballerini, Lavinia
Giuliani, Germano
Leone, Gemma
Lamponi, Stefania
Andreassi, Marco
Bonechi, Claudia
Donati, Alessandro
Piovani, Daniele
Schieroni, Alberto Giacometti
Magnani, Agnese
Cappelli, Andrea
author_facet Saletti, Mario
Paolino, Marco
Ballerini, Lavinia
Giuliani, Germano
Leone, Gemma
Lamponi, Stefania
Andreassi, Marco
Bonechi, Claudia
Donati, Alessandro
Piovani, Daniele
Schieroni, Alberto Giacometti
Magnani, Agnese
Cappelli, Andrea
author_sort Saletti, Mario
collection PubMed
description An easy and viable crosslinking procedure by click-chemistry (click-crosslinking) of hyaluronic acid (HA) was developed. In particular, the clickable propargyl groups of hyaluronane-based HA-FA-Pg graft copolymers showing low and medium molecular weight values were exploited in crosslinking by click-chemistry by using a hexa(ethylene glycol) spacer. The resulting HA-FA-HEG-CL materials showed an apparent lack of in vitro cytotoxic effects, tuneable water affinity, and rheological properties according to the crosslinking degree that suggests their applicability in different biomedical fields.
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spelling pubmed-91461102022-05-29 Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers Saletti, Mario Paolino, Marco Ballerini, Lavinia Giuliani, Germano Leone, Gemma Lamponi, Stefania Andreassi, Marco Bonechi, Claudia Donati, Alessandro Piovani, Daniele Schieroni, Alberto Giacometti Magnani, Agnese Cappelli, Andrea Pharmaceutics Article An easy and viable crosslinking procedure by click-chemistry (click-crosslinking) of hyaluronic acid (HA) was developed. In particular, the clickable propargyl groups of hyaluronane-based HA-FA-Pg graft copolymers showing low and medium molecular weight values were exploited in crosslinking by click-chemistry by using a hexa(ethylene glycol) spacer. The resulting HA-FA-HEG-CL materials showed an apparent lack of in vitro cytotoxic effects, tuneable water affinity, and rheological properties according to the crosslinking degree that suggests their applicability in different biomedical fields. MDPI 2022-05-11 /pmc/articles/PMC9146110/ /pubmed/35631626 http://dx.doi.org/10.3390/pharmaceutics14051041 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Saletti, Mario
Paolino, Marco
Ballerini, Lavinia
Giuliani, Germano
Leone, Gemma
Lamponi, Stefania
Andreassi, Marco
Bonechi, Claudia
Donati, Alessandro
Piovani, Daniele
Schieroni, Alberto Giacometti
Magnani, Agnese
Cappelli, Andrea
Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers
title Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers
title_full Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers
title_fullStr Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers
title_full_unstemmed Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers
title_short Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers
title_sort click-chemistry cross-linking of hyaluronan graft copolymers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146110/
https://www.ncbi.nlm.nih.gov/pubmed/35631626
http://dx.doi.org/10.3390/pharmaceutics14051041
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