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Immunosuppressive Tumor Microenvironment and Immunotherapy of Epstein–Barr Virus-Associated Malignancies

The Epstein–Barr virus (EBV) can cause different types of cancer in human beings when the virus infects different cell types with various latent patterns. EBV shapes a distinct and immunosuppressive tumor microenvironment (TME) to its benefit by influencing and interacting with different components...

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Autores principales: Zheng, Xueyi, Huang, Yuhua, Li, Kai, Luo, Rongzhen, Cai, Muyan, Yun, Jingping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146158/
https://www.ncbi.nlm.nih.gov/pubmed/35632758
http://dx.doi.org/10.3390/v14051017
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author Zheng, Xueyi
Huang, Yuhua
Li, Kai
Luo, Rongzhen
Cai, Muyan
Yun, Jingping
author_facet Zheng, Xueyi
Huang, Yuhua
Li, Kai
Luo, Rongzhen
Cai, Muyan
Yun, Jingping
author_sort Zheng, Xueyi
collection PubMed
description The Epstein–Barr virus (EBV) can cause different types of cancer in human beings when the virus infects different cell types with various latent patterns. EBV shapes a distinct and immunosuppressive tumor microenvironment (TME) to its benefit by influencing and interacting with different components in the TME. Different EBV-associated malignancies adopt similar but slightly specific immunosuppressive mechanisms by encoding different EBV products to escape both innate and adaptive immune responses. Strategies reversing the immunosuppressive TME of EBV-associated malignancies have been under evaluation in clinical practice. As the interactions among EBV, tumor cells, and TME are intricate, in this review, we mainly discuss the epidemiology of EBV, the life cycle of EBV, the cellular and molecular composition of TME, and a landscape of different EBV-associated malignancies and immunotherapy by targeting the TME.
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spelling pubmed-91461582022-05-29 Immunosuppressive Tumor Microenvironment and Immunotherapy of Epstein–Barr Virus-Associated Malignancies Zheng, Xueyi Huang, Yuhua Li, Kai Luo, Rongzhen Cai, Muyan Yun, Jingping Viruses Review The Epstein–Barr virus (EBV) can cause different types of cancer in human beings when the virus infects different cell types with various latent patterns. EBV shapes a distinct and immunosuppressive tumor microenvironment (TME) to its benefit by influencing and interacting with different components in the TME. Different EBV-associated malignancies adopt similar but slightly specific immunosuppressive mechanisms by encoding different EBV products to escape both innate and adaptive immune responses. Strategies reversing the immunosuppressive TME of EBV-associated malignancies have been under evaluation in clinical practice. As the interactions among EBV, tumor cells, and TME are intricate, in this review, we mainly discuss the epidemiology of EBV, the life cycle of EBV, the cellular and molecular composition of TME, and a landscape of different EBV-associated malignancies and immunotherapy by targeting the TME. MDPI 2022-05-10 /pmc/articles/PMC9146158/ /pubmed/35632758 http://dx.doi.org/10.3390/v14051017 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zheng, Xueyi
Huang, Yuhua
Li, Kai
Luo, Rongzhen
Cai, Muyan
Yun, Jingping
Immunosuppressive Tumor Microenvironment and Immunotherapy of Epstein–Barr Virus-Associated Malignancies
title Immunosuppressive Tumor Microenvironment and Immunotherapy of Epstein–Barr Virus-Associated Malignancies
title_full Immunosuppressive Tumor Microenvironment and Immunotherapy of Epstein–Barr Virus-Associated Malignancies
title_fullStr Immunosuppressive Tumor Microenvironment and Immunotherapy of Epstein–Barr Virus-Associated Malignancies
title_full_unstemmed Immunosuppressive Tumor Microenvironment and Immunotherapy of Epstein–Barr Virus-Associated Malignancies
title_short Immunosuppressive Tumor Microenvironment and Immunotherapy of Epstein–Barr Virus-Associated Malignancies
title_sort immunosuppressive tumor microenvironment and immunotherapy of epstein–barr virus-associated malignancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146158/
https://www.ncbi.nlm.nih.gov/pubmed/35632758
http://dx.doi.org/10.3390/v14051017
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