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Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System
Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of compounds into cells. Since the discovery of the first members of this peptide family, many other peptides have been identified; nowadays, dozens of these peptides are known. These peptides sometimes have very...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146218/ https://www.ncbi.nlm.nih.gov/pubmed/35631493 http://dx.doi.org/10.3390/pharmaceutics14050907 |
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author | Szabó, Ildikó Yousef, Mo’ath Soltész, Dóra Bató, Csaba Mező, Gábor Bánóczi, Zoltán |
author_facet | Szabó, Ildikó Yousef, Mo’ath Soltész, Dóra Bató, Csaba Mező, Gábor Bánóczi, Zoltán |
author_sort | Szabó, Ildikó |
collection | PubMed |
description | Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of compounds into cells. Since the discovery of the first members of this peptide family, many other peptides have been identified; nowadays, dozens of these peptides are known. These peptides sometimes have very different chemical–physical properties, but they have similar drawbacks; e.g., non-specific internalization, fast elimination from the body, intracellular/vesicular entrapment. Although our knowledge regarding the mechanism and structure–activity relationship of internalization is growing, the prediction and design of the cell-penetrating properties are challenging. In this review, we focus on the different modifications of well-known CPPs to avoid their drawbacks, as well as how these modifications may increase their internalization and/or change the mechanism of penetration. |
format | Online Article Text |
id | pubmed-9146218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91462182022-05-29 Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System Szabó, Ildikó Yousef, Mo’ath Soltész, Dóra Bató, Csaba Mező, Gábor Bánóczi, Zoltán Pharmaceutics Review Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of compounds into cells. Since the discovery of the first members of this peptide family, many other peptides have been identified; nowadays, dozens of these peptides are known. These peptides sometimes have very different chemical–physical properties, but they have similar drawbacks; e.g., non-specific internalization, fast elimination from the body, intracellular/vesicular entrapment. Although our knowledge regarding the mechanism and structure–activity relationship of internalization is growing, the prediction and design of the cell-penetrating properties are challenging. In this review, we focus on the different modifications of well-known CPPs to avoid their drawbacks, as well as how these modifications may increase their internalization and/or change the mechanism of penetration. MDPI 2022-04-21 /pmc/articles/PMC9146218/ /pubmed/35631493 http://dx.doi.org/10.3390/pharmaceutics14050907 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Szabó, Ildikó Yousef, Mo’ath Soltész, Dóra Bató, Csaba Mező, Gábor Bánóczi, Zoltán Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System |
title | Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System |
title_full | Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System |
title_fullStr | Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System |
title_full_unstemmed | Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System |
title_short | Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System |
title_sort | redesigning of cell-penetrating peptides to improve their efficacy as a drug delivery system |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146218/ https://www.ncbi.nlm.nih.gov/pubmed/35631493 http://dx.doi.org/10.3390/pharmaceutics14050907 |
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