Cargando…

Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System

Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of compounds into cells. Since the discovery of the first members of this peptide family, many other peptides have been identified; nowadays, dozens of these peptides are known. These peptides sometimes have very...

Descripción completa

Detalles Bibliográficos
Autores principales: Szabó, Ildikó, Yousef, Mo’ath, Soltész, Dóra, Bató, Csaba, Mező, Gábor, Bánóczi, Zoltán
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146218/
https://www.ncbi.nlm.nih.gov/pubmed/35631493
http://dx.doi.org/10.3390/pharmaceutics14050907
_version_ 1784716506492305408
author Szabó, Ildikó
Yousef, Mo’ath
Soltész, Dóra
Bató, Csaba
Mező, Gábor
Bánóczi, Zoltán
author_facet Szabó, Ildikó
Yousef, Mo’ath
Soltész, Dóra
Bató, Csaba
Mező, Gábor
Bánóczi, Zoltán
author_sort Szabó, Ildikó
collection PubMed
description Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of compounds into cells. Since the discovery of the first members of this peptide family, many other peptides have been identified; nowadays, dozens of these peptides are known. These peptides sometimes have very different chemical–physical properties, but they have similar drawbacks; e.g., non-specific internalization, fast elimination from the body, intracellular/vesicular entrapment. Although our knowledge regarding the mechanism and structure–activity relationship of internalization is growing, the prediction and design of the cell-penetrating properties are challenging. In this review, we focus on the different modifications of well-known CPPs to avoid their drawbacks, as well as how these modifications may increase their internalization and/or change the mechanism of penetration.
format Online
Article
Text
id pubmed-9146218
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91462182022-05-29 Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System Szabó, Ildikó Yousef, Mo’ath Soltész, Dóra Bató, Csaba Mező, Gábor Bánóczi, Zoltán Pharmaceutics Review Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of compounds into cells. Since the discovery of the first members of this peptide family, many other peptides have been identified; nowadays, dozens of these peptides are known. These peptides sometimes have very different chemical–physical properties, but they have similar drawbacks; e.g., non-specific internalization, fast elimination from the body, intracellular/vesicular entrapment. Although our knowledge regarding the mechanism and structure–activity relationship of internalization is growing, the prediction and design of the cell-penetrating properties are challenging. In this review, we focus on the different modifications of well-known CPPs to avoid their drawbacks, as well as how these modifications may increase their internalization and/or change the mechanism of penetration. MDPI 2022-04-21 /pmc/articles/PMC9146218/ /pubmed/35631493 http://dx.doi.org/10.3390/pharmaceutics14050907 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Szabó, Ildikó
Yousef, Mo’ath
Soltész, Dóra
Bató, Csaba
Mező, Gábor
Bánóczi, Zoltán
Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System
title Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System
title_full Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System
title_fullStr Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System
title_full_unstemmed Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System
title_short Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System
title_sort redesigning of cell-penetrating peptides to improve their efficacy as a drug delivery system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146218/
https://www.ncbi.nlm.nih.gov/pubmed/35631493
http://dx.doi.org/10.3390/pharmaceutics14050907
work_keys_str_mv AT szaboildiko redesigningofcellpenetratingpeptidestoimprovetheirefficacyasadrugdeliverysystem
AT yousefmoath redesigningofcellpenetratingpeptidestoimprovetheirefficacyasadrugdeliverysystem
AT solteszdora redesigningofcellpenetratingpeptidestoimprovetheirefficacyasadrugdeliverysystem
AT batocsaba redesigningofcellpenetratingpeptidestoimprovetheirefficacyasadrugdeliverysystem
AT mezogabor redesigningofcellpenetratingpeptidestoimprovetheirefficacyasadrugdeliverysystem
AT banoczizoltan redesigningofcellpenetratingpeptidestoimprovetheirefficacyasadrugdeliverysystem